Leonurine protects ischemia-induced brain injury via modulating SOD, MDA and GABA levels

doi:10.15302/J-FASE-2018245

Frontiers of Agricultural Science and Engineering

2019, Vol. 6

Issue (2): 197-205 https://doi.org/10.15302/J-FASE-2018245

本期目录

Leonurine protects ischemia-induced brain injury via modulating SOD, MDA and GABA levels

Shilei ZHENG, Jingru ZHU, Jiao LI, Shuang ZHANG, Yunfei MA(

)

College of Veterinary Medicine, China Agricultural University, Beijing 100193, China

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Abstract：

The present study was designed to investigate the protective effects of leonurine, a compound purified from Herba Leonuri that is active on ischemic rat behavior and cortical neurons, and explore the underlying mechanism. The general rat activity, cortical neuron morphology, superoxide dismutase (SOD), malondialdehyde (MDA), g-aminobutyric acid (GABA) and glutamate decarboxylase 67 (GAD67) levels were measured. We found leonurine significantly improve the general activity of rats in an open-field test, which was associated with attenuated neuronal damage induced by ischemia. Moreover, serum SOD activity was significantly greater, MDA level lower in the leonurine group as compared with ischemia group. In addition, GABA content in the cerebral cortex was significantly greater in high-dose leonurine group. Correspondingly, GAD67 protein level coincided with the GABA level. Taken together, our results demonstrated that leonurine attenuated brain injury during ischemia via antioxidative and anti-excitotoxicity effects by targeting GABA and leonurine might become a useful adjuvant neuroprotective agent.

Key words： cerebral ischemia GABA neuroprotection leonurine SOD

收稿日期: 2018-06-10 出版日期: 2019-05-22

Corresponding Author(s): Yunfei MA

引用本文:

. [J]. Frontiers of Agricultural Science and Engineering, 2019, 6(2): 197-205.
Shilei ZHENG, Jingru ZHU, Jiao LI, Shuang ZHANG, Yunfei MA. Leonurine protects ischemia-induced brain injury via modulating SOD, MDA and GABA levels. Front. Agr. Sci. Eng. , 2019, 6(2): 197-205.

链接本文:

https://academic.hep.com.cn/fase/CN/10.15302/J-FASE-2018245
https://academic.hep.com.cn/fase/CN/Y2019/V6/I2/197

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