Konjac glucomannan and xanthan gum as compression
coat for colonic drug delivery: experimental and theoretical evaluations
Konjac glucomannan and xanthan gum as compression
coat for colonic drug delivery: experimental and theoretical evaluations
Kang WANG,Jiangyang FAN,Yanjun LIU,Zhimin HE,
Enzyme Technology Laboratory,
Chemical Engineering Research Center, School of Chemical Engineering
and Technology, Tianjin University, Tianjin 300072, China;
Abstract：Compression coated tablets for oral colon specific delivery systems were developed with a mixture polysaccharide of konjac glucomannan (KGM) and xanthan gum (XG) as the compression coat. Diffusion of cimetidine from compression coated tablets was investigated by release experiment in Vitro. 0.22U/mL β-mannanase was applied in the mimic colon solution. The structure of the mixture polysaccharide was studied by an atomic force microscope (AFM). The experimental results indicate that a KGM70 tablet with a 0.4g coat is of good design, due to a less than 5% drug loss in the mimic upper gastrointestinal solution by the synergistic interaction between XG and KGM, and due to about 50% cumulative release in the mimic colon solution by degradation after 24 hours. The release mechanism and model are discussed based on different periods of drug release including the delay of the drug, the constant release without an enzyme and the delay of degradation. Under hydrolysis by β-mannanase, drug release from the tablet with KGM coat shows an exponential increase, while that from the dosage with the mixture polysaccharide coat is an approximately zero-order process in which the constant release rate relates to the release velocity of a non-degraded system, the content of KGM within the coat and the average molecular weight ratio of KGM to XG. It was found that XG was the framework of the polysaccharide mixtures by AFM, which is similar to the analysis results from experiments on drug release.
出版日期: 2010-03-05
引用本文:
. Konjac glucomannan and xanthan gum as compression
coat for colonic drug delivery: experimental and theoretical evaluations[J]. Front. Chem. Sci. Eng., 2010, 4(1): 102-108.
Kang WANG, Jiangyang FAN, Yanjun LIU, Zhimin HE, . Konjac glucomannan and xanthan gum as compression
coat for colonic drug delivery: experimental and theoretical evaluations. Front. Chem. Sci. Eng., 2010, 4(1): 102-108.
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