Valorisation of protein waste: An enzymatic approach to make commodity chemicals? ?
Madura B. A. Kumar1,Yuan Gao2,Wei Shen1,Lizhong He1,*()
1. Department of Chemical Engineering, Monash University, Clayton, VIC 3800, Australia
2. Manufacturing Flagship, Commonwealth Scientific and Industrial Research Organization, Bayview Avenue, Clayton, VIC 3168, Australia
Protein-rich waste is an abundantly available resource that is currently used mainly as animal feed and fertilizers. Valorisation of protein waste to higher value products, particularly commodity chemicals such as precursors for polymers, has attracted significant research efforts. Enzyme-based approaches, being environmentally-friendly compared to their chemical counterparts, promise sustainable processes for conversion of protein waste to valuable chemicals. This review provides a general overview on valorisation of protein waste and then further summarises the use of enzymes in different stages of the valorisation process—protein extraction and hydrolysis, separation of individual amino acids and their ultimate conversion into chemicals. Case studies of enzymatic conversion are presented for different amino acids including glutamic acid, lysine, phenylalanine, tyrosine, arginine and aspartic acid. The review compares the different enzyme reactors and operation modes for amino acid conversion. The emerging opportunities and challenges in the field are discussed: engineering powerful enzymes and integrating innovative processes for industrial application at a low cost.
. [J]. Frontiers of Chemical Science and Engineering, 2015, 9(3): 295-307.
Madura B. A. Kumar, Yuan Gao, Wei Shen, Lizhong He. Valorisation of protein waste: An enzymatic approach to make commodity chemicals? ?. Front. Chem. Sci. Eng., 2015, 9(3): 295-307.
Lysine monooxygenase and 5-Aminovaleramide amidohydrolase
P. putida KT2440
[51]
Lysine
Cadaverine dicarboxylate
Lysine decarboxylase
Not disclosed
[52]
Phenylalanine
Cinnamic acid
Phenylalanine ammonia lyase
Not disclosed
[53]
Tyrosine
Para-hydroxycinnamic acid
Tyrosine ammonia lyase
R. glutinis
[54]
P. chrysosporium
[54]
Arginine
Ornithine
Arginine amidinohydrolase
B. subtilis KY 3281
[10,55]
Aspartic acid
β-Alanine
Aspartate α-decarboxylase
E. coli W
[56,57]
Aspartate
β-Alanine
Aspartate α-decarboxylase
C. glutamicum
[58]
Tab.3
Fig.1
Fig.2
Fig.3
Fig.4
Fig.5
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