Despite all major breakthroughs in recent years of research, we are still unsuccessful to effectively diagnose and treat cancer that has express and metastasizes. Thus, the development of a novel approach for cancer detection and treatment is crucial. Recent progress in Glyconanotechnology has allowed the use of glycans and lectins as bio-functional molecules for many biological and biomedical applications. With the known advantages of quantum dots (QDs) and versatility of carbohydrates and lectins, Glyco-functionalised QD is a new prospect in constructing biomedical imaging platform for cancer behaviour study as well as treatment. In this review, we aim to describe the current utilisation of Glyco-functionalised QDs as well as their future prospective to interpret and confront cancer.
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Jayshree Ashree, Qi Wang, Yimin Chao. Glyco-functionalised quantum dots and their progress in cancer diagnosis and treatment. Front. Chem. Sci. Eng., 2020, 14(3): 365-377.
a-Glucose, a-N-acetylglucose, b-galactose, mannose or sialic acid
ZnS-AgInS2 QDs
Asialoglycoprotein receptors
Leukemia (THP-1), macrophage (J774.A1) and HepG2 cells
[58]
Cancer cell imaging
D-Mannose
Silicon QDs
?
MCF-7 cells
[59]
Cancer cell imaging
Glucose, lactose
Silicon QDs
?
B16F10 melanoma cells
[60]
Cancer cell imaging
Glucose
Silicon QDs
?
HeLa cells
[61]
Cancer targeting
Galactose
CdTe/ZnS-TOPO
Asialoglycoprotein receptors
HeLa and A549 cells
[62]
Cancer targeting
D-Mannose
Silicon QDs
?
MCF-7 cells
[63]
Cancer targeting
Galactose, glucose, mannose, and lactose
Silicon QDs
?
MCF-7, HepG2, A549, SK-Mel, HHL5, HeLa cells
[64]
Cancer targeting
Galactose
CdSe-ZnS QDs
Galactose receptors
HepG2 and HeLa cells
[65]
Cancer theranostics
Mannose
Albumin-CdTe QDs
?
MCF-7 and MDA-MB-231 cells, Ehrlich ascites tumour in BALB/C mice
[66]
Tab.2
Fig.3
Fig.4
Fig.5
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