Diporphyrin tweezer for multichannel spectroscopic analysis of enantiomeric excess
Daniel T. Payne1(), Mandeep K. Chahal1, Václav Březina2, Whitney A. Webre3, Katsuhiko Ariga1,4, Francis D’Souza3, Jan Labuta1(), Jonathan P. Hill1()
1. WPI Center for Materials Nanoarchitectonics, National Institute for Materials Science, Ibaraki 305-0044, Japan 2. Department of Macromolecular Physics, Faculty of Mathematics and Physics, Charles University, 18000 Prague, Czech Republic 3. Department of Chemistry, University of North Texas, Denton, TX 76203, USA 4. Department of Advanced Materials Science, Graduate School of Frontier Sciences, The University of Tokyo, Chiba 277-8561, Japan
Chiral 1,1’-binaphthyl-linked diporphyrin ‘tweezers’ (R)-1/(S)-1 and the corresponding zinc(II) complexes (R)-2/(S)-2 were prepared as chiral host molecules, and their utility for chiral analyses (especially enantiomeric excess (ee) determinations) were evaluated. Tris(1-n-dodecyl)porphyrins were used for the first time as the interacting units. Host capabilities of the diporphyrin tweezers were investigated by titrations with (R,R)- and (S,S)-cyclohexane-1,2-diamine (CHDA). The host molecules could be used as multichannel probes of ee by using UV-vis, circular dichroism (CD), fluorescence emission and 1H nuclear magnetic resonance (1H-NMR) methods. Chiral configurations could also be differentiated using CD or 1H-NMR spectroscopy. All three optical techniques give good resolution of ee with reasonable sensitivity considering the low concentrations used (ca. 10−6 mol·L−1). The ee determination of CHDA enantiomers using NMR spectroscopy is also possible because of the reasonably well separated resonances in the case of (R,R)- and (S,S)-CHDA. Non-metallated (R)-1/(S)-1 hosts could not be used to detect chiral information in a strongly acidic chiral guest. This work demonstrates the utility of 1,1’-binapthyl-linked chiral hosts for chiral analysis of ditopically interacting enantiomers.
Corresponding Author(s):
Daniel T. Payne,Jan Labuta,Jonathan P. Hill
引用本文:
. [J]. Frontiers of Chemical Science and Engineering, 2020, 14(1): 28-40.
Daniel T. Payne, Mandeep K. Chahal, Václav Březina, Whitney A. Webre, Katsuhiko Ariga, Francis D’Souza, Jan Labuta, Jonathan P. Hill. Diporphyrin tweezer for multichannel spectroscopic analysis of enantiomeric excess. Front. Chem. Sci. Eng., 2020, 14(1): 28-40.
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