Novel lysosome-targeted anticancer fluorescent agents used in zebrafish and nude mouse tumour imaging
Xiuli Chen1,2, Feng Liu1, Bin Chen3, Haiying Wu2, Kun Li1, Yongmei Xie1, Weihong Kuang4(), Zhihui Li1,3()
1. Department of Thyroid Surgery, West China Hospital of Sichuan University, Chengdu 610041, China 2. Department of Obstetrics, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou 450003, China 3. Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-related Molecular Network, Rare Diseases Center, West China Hospital of Sichuan University, Chengdu 610041, China 4. Department of Psychiatry and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, China
The design of three novel fatty nitrogen mustard-based anticancer agents with fluorophores incorporated into the alkene structure (CXL 118, CXL121, and CXL122) is described in this report. The results indicated that these compounds are selectively located in lysosomes and exhibit effective antitumour activity. Notably, these compounds can directly serve as both reporting and imaging agents in vitro and in vivo without the need to add other fluorescent tagging agents.
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