A power analysis for future clinical trials on the potential adverse effects of SSRIs on amygdala reactivity

doi:10.1007/s11515-016-1402-6

Frontiers in Biology

2016, Vol. 11

Issue (3): 256-259 https://doi.org/10.1007/s11515-016-1402-6

本期目录

A power analysis for future clinical trials on the potential adverse effects of SSRIs on amygdala reactivity

M. A. Bottelier^1,²,A. Schrantee^2,³,G. van Wingen⁴,H. G. Ruhé^4,⁵,M. B. de Ruiter^2,³,L. Reneman^2,^3,^*(

)

¹. Department of Child- and Adolescent Psychiatry, Triversum, Alkmaar, The Netherlands
². Brain Imaging Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
³. Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands
⁴. Department of Psychiatry, Academic Medical Center, Amsterdam, The Netherlands
⁵. Program for Mood and Anxiety Disorders, Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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Abstract：

Treatment of adolescents with antidepressants may induce an increased risk for suicidality in this population. The activity of the amygdala during processing of emotional faces with functional Magnetic Resonance Imaging (fMRI) is a well-known measure of emotional dysregulation. Based upon data of our prematurely ended randomized clinical trial with fluoxetine (NTR3103) in anxious and or depressed girls (12–14 years of age) we calculated that with the found effect size of r = 0.66, compared to placebo, only 8 subjects are needed to demonstrate increased amygdala activity following 16 weeks of treatment with fluoxetine.

Key words： amygdala reactivity SSRI adverse effects anxiety depression

收稿日期: 2016-01-31 出版日期: 2016-07-05

Corresponding Author(s): L. Reneman

引用本文:

. [J]. Frontiers in Biology, 2016, 11(3): 256-259.
M. A. Bottelier,A. Schrantee,G. van Wingen,H. G. Ruhé,M. B. de Ruiter,L. Reneman. A power analysis for future clinical trials on the potential adverse effects of SSRIs on amygdala reactivity. Front. Biol., 2016, 11(3): 256-259.

链接本文:

https://academic.hep.com.cn/fib/CN/10.1007/s11515-016-1402-6
https://academic.hep.com.cn/fib/CN/Y2016/V11/I3/256

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