1. State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou 310027, China 2. Deparment of Cell Biology, Zhejiang University School of Medicine, Hangzhou 310058, China 3. State Key Laboratory of Modern Optical Instrumentation, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou 310058, China 4. Collaborative Innovation Center of Extreme Optics, Shanxi University, Taiyuan 030006, China
In this review, we introduce some chip-based waveguide biosensing and imaging techniques, which significantly reduce the complexity of the entire system. These techniques use a well-confined evanescent field to interact with the surrounding materials and achieve high sensitivity sensing and high signal-to-noise ratio (SNR) super-resolution imaging. The fabrication process of these chips is simple and compatible with conventional semiconductor fabrication methods, allowing high-yield production. Combined with recently developed chip-based light sources, these techniques offer the possibility of biosensing and super-resolution imaging based on integrated circuits.
