1. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China; 2. Inner Mongolia People’s Hospital, Hohhot 010017, China; 3. Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing 100102, China; 4. The First Affiliated Hospital of Kunming Medical College, Kunming 650032, China; 5. Beijing University of Traditional Chinese Medicine Oriental Hospital, Beijing 100078, China; 6. Tongliao Hospital, Tongliao 026000, China; 7. China Association Against Epilepsy, Beijing 100044, China; 8. Kunming Chinese Medicine Factory Co., Ltd., Kunming 650228, China
We observed the effect of Dianxianning, which was used as additive treatment to treat 206 epilepsy patients, on the epilepsy seizure rate. Based on a multicenter, prospective, randomized, and controlled clinical trial design, we used the seizure rate of epilepsy as the main index. For the treatment group comprising 137 patients, we combined Dianxianning with chemical medicine, which is the basic treatment. For the control group with 69 patients, we added placebo. The results showed that 1) Effect on seizure rate: After a three-month treatment, the seizure rate of the treatment group decreased by 37.84% on average, whereas that of the control group decreased by 13.18% on average. Statistically comparing the two groups, there was a significant difference between these groups (P<0.05). 2) Effect on seizure frequency: As time passed, the frequency in each group gradually decreased. After a three-month treatment, there was a significant difference between the two groups (P<0.05). 3) Comparison between the before and after treatment of each group: There was a very significant difference between the two groups (P<0.0001). The results indicated that, as an additive treatment, Dianxianning has a good effect on controlling the epilepsy seizure rate and frequency management. It is more effective than using chemical medicine alone.
Corresponding Author(s):
He Liyun,Email:hely3699@163.com
引用本文:
. Reevaluation of the effect of Dianxianning on seizure rate of refractory epilepsy as additive treatment in clinical practice[J]. Frontiers of Medicine, 2011, 5(2): 229-234.
Liyun He, Tiancai Wen, Shiyan Yan, Runjin Li, Zufa Liu, Hui Ren, Jinmin Liu, Fengshan Zhang, Jianzhong Wu, Jian Liu. Reevaluation of the effect of Dianxianning on seizure rate of refractory epilepsy as additive treatment in clinical practice. Front Med, 2011, 5(2): 229-234.
Forsgren L, Beghi E, Oun A, Sillanp?? M. The epidemiology of epilepsy in Europe — a systematic review. Eur J Neurol 2005; 12(4): 245–253 doi: 10.1111/j.1468-1331.2004.00992.x
Zhu Q, Yuan XR, Sun ZD. The epidemiological and sociological analysis, current situation and our strategies of the epilepsy. J Shanxi Med Univ (Preclinical Med Educ Ed)(Shan Xi Yi Ke Da Xue Xue Bao: Ji Chu Yi Xue Jiao Yu Ban) 2005; 7 (2): 218 (in Chinese)
4
Zhang YQ. Overview of traditional Chinese medical research on epilepsy. J Liaoning Univ Tradit Chin Med(Liao Ning Zhong Yi Yao Da Xue Xue Bao) 2007; 9(1): 164–165 (in Chinese)
5
He LY, Li RJ, Liu ZF, Ren H. Influence of Dianxianning tablet as an added medicine on the severity of epileptic paroxysm. J Tradit Chin Med (Zhong Yi Za Zhi) 2010; 51(9): 797–800 (in Chinese)
6
Ministry of Health of the People’s Republic of China. Guidelines for new drug clinical research of Chinese medicine. 1993: 179–181 (in Chinese)
7
Seino M. Classification criteria of epileptic seizures and syndromes. Epilepsy Res 2006; 70(Supplement): 27–33 doi: 10.1016/j.eplepsyres.2006.01.016
8
Sun Y, Yang RM. Practical neurology of integrated traditional Chinese and western medicine. Beijing: People’s Medical Publishing House, 1999: 458–460 (in Chinese)
9
The General Logistics Department of PLA. Criteria for disease diagnosis, healing and improvement.1st Ed. Beijing: People’s Military Medical Press ,1987: 401–403 (in Chinese)
10
Chen L, Zheng QM, Zheng HC, Qin LP, Nian H. Advances in study on Valeriana wallichii DC. Chin Wild Plant Resour 2002; 21(1): 8–11
