Association of SIPA1 545 C>T polymorphism with survival in Chinese women with metastatic breast cancer
Association of SIPA1 545 C>T polymorphism with survival in Chinese women with metastatic breast cancer
Renling Pei, Ye Xu, Yan Wei, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Yuntao Xie()
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Breast Center, Beijing Cancer Hospital & Institute, Peking University Cancer Hospital, Beijing 100142, China
It has been demonstrated that single nucleotide polymorphisms (SNPs) of SIPA1 (signal-induced proliferation associated gene 1) are associated with metastatic efficiency in both human and rodents. The purpose of this study was to determine whether SIPA1 545 C>T polymorphism was associated with overall survival in patients with metastatic breast cancer. In this study, SIPA1 545 C>T polymorphism was detected in 185 metastatic breast cancer patients using polymerase chain reaction-restriction fragment length polymorphism assay (PCR-RFLP). Survival curves for patients with SIPA1 545 C>T polymorphism was compared using the Kaplan-Meier method with log-rank tests. We found that SIPA1 545 C>T polymorphism was significantly associated with survival in 185 patients with metastatic breast cancer. Patients with SIPA1 545 T/T genotype had a significantly worse overall survival (OS) than did patients with C/T or C/C genotype (50.0% vs. 62.9%, P = 0.042). Moreover, in multivariate analysis, as compared with the C/C or C/T genotype, the T/T genotype remained an independent unfavorable prognostic marker of OS in this cohort (hazard ratio [HR] = 2.16; 95% CI= 1.12–4.15; P = 0.022). Our findings indicate that metastatic breast cancer patients with SIPA1 545 T/T genotype have a poorer survival compared to patients with C/C or C/T genotype.
. Association of SIPA1 545 C>T polymorphism with survival in Chinese women with metastatic breast cancer[J]. Frontiers of Medicine, 2013, 7(1): 138-142.
Renling Pei, Ye Xu, Yan Wei, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Yuntao Xie. Association of SIPA1 545 C>T polymorphism with survival in Chinese women with metastatic breast cancer. Front Med, 2013, 7(1): 138-142.
Gerber B, Freund M, Reimer T. Recurrent breast cancer: treatment strategies for maintaining and prolonging good quality of life. Dtsch Arztebl Int 2010; 107(6): 85–91 pmid:20204119
2
Cardoso F, Harbeck N, Fallowfield L, Kyriakides S, Senkus E ;ESMO Guidelines Working Group.Locally recurrent or metastatic breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2012; 23(Suppl 7): vii11–vii19 doi: 10.1093/annonc/mds232 pmid:22997442
3
Wada Y, Kubota H, Maeda M, Taniwaki M, Hattori M, Imamura S, Iwai K, Minato N. Mitogen-inducible SIPA1 is mapped to the conserved syntenic groups of chromosome 19 in mouse and chromosome 11q13.3 centromeric to BCL1 in human. Genomics 1997; 39(1): 66–73 doi: 10.1006/geno.1996.4464 pmid:9027487
4
Hattori M, Tsukamoto N, Nur-e-Kamal MS, Rubinfeld B, Iwai K, Kubota H, Maruta H, Minato N. Molecular cloning of a novel mitogen-inducible nuclear protein with a Ran GTPase-activating domain that affects cell cycle progression. Mol Cell Biol 1995; 15(1): 552–560 pmid:7799964
Hogan C, Serpente N, Cogram P, Hosking CR, Bialucha CU, Feller SM, Braga VM, Birchmeier W, Fujita Y. Rap1 regulates the formation of E-cadherin-based cell-cell contacts. Mol Cell Biol 2004; 24(15): 6690–6700 doi: 10.1128/MCB.24.15.6690-6700.2004 pmid:15254236
7
Hoshino T, Sakisaka T, Baba T, Yamada T, Kimura T, Takai Y. Regulation of E-cadherin endocytosis by nectin through afadin, Rap1, and p120ctn. J Biol Chem 2005; 280(25): 24095–24103 doi: 10.1074/jbc.M414447200 pmid:15857834
8
Katagiri K, Hattori M, Minato N, Irie S, Takatsu K, Kinashi T. Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and phosphatidylinositol-3-OH kinase. Mol Cell Biol 2000; 20(6): 1956–1969 doi: 10.1128/MCB.20.6.1956-1969.2000 pmid:10688643
9
Tsukamoto N, Hattori M, Yang H, Bos JL, Minato N. Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion. J Biol Chem 1999; 274(26): 18463–18469 doi: 10.1074/jbc.274.26.18463 pmid:10373454
10
Shimizu Y, Hamazaki Y, Hattori M, Doi K, Terada N, Kobayashi T, Toda Y, Yamasaki T, Inoue T, Kajita Y, Maeno A, Kamba T, Mikami Y, Kamoto T, Yamada T, Kanno T, Yoshikawa K, Ogawa O, Minato N, Nakamura E. SPA-1 controls the invasion and metastasis of human prostate cancer. Cancer Sci 2011; 102(4): 828–836 doi: 10.1111/j.1349-7006.2011.01876.x pmid:21251160
11
Crawford NP, Ziogas A, Peel DJ, Hess J, Anton-Culver H, Hunter KW. Germline polymorphisms in SIPA1 are associated with metastasis and other indicators of poor prognosis in breast cancer. Breast Cancer Res 2006; 8(2): R16 doi: 10.1186/bcr1389 pmid:16563182
12
Kurachi H, Wada Y, Tsukamoto N, Maeda M, Kubota H, Hattori M, Iwai K, Minato N. Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. Segregate expression profiles from a rap1GAP gene product. J Biol Chem 1997; 272(44): 28081–28088 doi: 10.1074/jbc.272.44.28081 pmid:9346962
13
Park YG, Zhao X, Lesueur F, Lowy DR, Lancaster M, Pharoah P, Qian X, Hunter KW. SIPA1 is a candidate for underlying the metastasis efficiency modifier locus Mtes1. Nat Genet 2005; 37(10): 1055–1062 doi: 10.1038/ng1635 pmid:16142231
14
Hsieh SM, Look MP, Sieuwerts AM, Foekens JA, Hunter KW. Distinct inherited metastasis susceptibility exists for different breast cancer subtypes: a prognosis study. Breast Cancer Res 2009; 11(5): R75 doi: 10.1186/bcr2412 pmid:19825179
15
Hsieh SM, Smith RA, Lintell NA, Hunter KW, Griffiths LR. Polymorphisms of the SIPA1 gene and sporadic breast cancer susceptibility. BMC Cancer 2009; 9(1): 331 doi: 10.1186/1471-2407-9-331 pmid:19765277
16
Liu F, Wu Y, Xu Y, . Association of SIPA1-545(C/T)Polymorphism with Breast Cancer Risk and Tumor Characteristics in Chinese Women. Chin J Clin Oncol (Zhongguo Zhong Liu Lin Chuang) 2009; 36: 1183–1186 (in Chinese)
17
Weigelt B, Peterse JL, van ’t Veer LJ. Breast cancer metastasis: markers and models. Nat Rev Cancer 2005; 5(8): 591–602 doi: 10.1038/nrc1670 pmid:16056258
