Resistome is a cluster of microbial genes encoding proteins with necessary functions to resist the action of antibiotics. Resistome governs essential and separate biological functions to develop resistance against antibiotics. The widespread clinical and nonclinical uses of antibiotics over the years have combined to select antibiotic-resistant determinants and develop resistome in bacteria. At present, the emergence of drug resistance because of resistome is a significant problem faced by clinicians for the treatment of Salmonella infection. Antibiotic resistome is a dynamic and ever-expanding component in Salmonella. The foundation of resistome in Salmonella is laid long before; therefore, the antibiotic resistome of Salmonella is reviewed, discussed, and summarized. We have searched the literature using PubMed, MEDLINE, and Google Scholar with related key terms (resistome, Salmonella, antibiotics, drug resistance) and prepared this review. In this review, we summarize the status of resistance against antibiotics in S. typhi, highlight the seminal work in the resistome of S. typhi and the genes involved in the antibiotic resistance, and discuss the various methods to identify S. typhi resistome for the proactive identification of this infection and quick diagnosis of the disease.
. [J]. Frontiers of Medicine, 2021, 15(5): 693-703.
Awanish Kumar, Anil Kumar. Antibiotic resistome of Salmonella typhi: molecular determinants for the emergence of drug resistance. Front. Med., 2021, 15(5): 693-703.
Targets the 30S subunit of the bacterial ribosome binding to the ribosome and inhibiting protein synthesis
Das et al., 2017 [11]; Frye et al., 2013 [16]
Tab.1
1
GO Abakpa, VJ Umoh, JB Ameh, SE Yakubu, JKP Kwaga, S Kamaruzaman. Diversity and antimicrobial resistance of Salmonella enterica isolated from fresh produce and environmental samples. Environ Nanotechnol Monit Manag 2015; 3: 38–46 https://doi.org/10.1016/j.enmm.2014.11.004
2
LS Wei, W Wee, JYF Siong, DF Syamsumir. Characterization of anticancer, antimicrobial, antioxidant properties and chemical compositions of Peperomia pellucida leaf extract. Acta Med Iran 2011; 49(10): 670–674
pmid: 22071643
3
A Mahapatra, S Patro, S Choudhury, A Padhee, R Das. Emerging enteric fever due to switching biotype of Salmonella (paratyphi A) in Eastern Odisha. Indian J Pathol Microbiol 2016; 59(3): 327–329 https://doi.org/10.4103/0377-4929.188124
pmid: 27510670
4
JA Crump, ED Mintz. Global trends in typhoid and paratyphoid fever. Clin Infect Dis 2010; 15; 50(2): 241–246
5
A Tatavarthy, VA Luna, PT Amuso. How multidrug resistance in typhoid fever affects treatment options. Ann N Y Acad Sci 2014; 1323(1): 76–90 https://doi.org/10.1111/nyas.12490
pmid: 25069595
6
WHO. Vaccine-preventable diseases surveillance standards: typhoid and other invasive salmonellosis. WHO 2019; 1–13. (accessed January 11, 2020)
7
S Chitnis, V Chitnis, N Hemvani, DS Chitnis. Ciprofloxacin therapy for typhoid fever needs reconsideration. J Infect Chemother 2006; 12(6): 402–404 https://doi.org/10.1007/s10156-006-0472-9
pmid: 17235649
8
CS Chiou, TL Lauderdale, DC Phung, H Watanabe, JC Kuo, PJ Wang, YY Liu, SY Liang, PC Chen. Antimicrobial resistance in Salmonella enterica serovar typhi isolates from Bangladesh, Indonesia, Chinese Taiwan, and Vietnam. Antimicrob Agents Chemother 2014; 58(11): 6501–6507 https://doi.org/10.1128/AAC.03608-14
pmid: 25136011
9
S Rai, S Jain, KN Prasad, U Ghoshal, TN Dhole. Rationale of azithromycin prescribing practices for enteric fever in India. Indian J Med Microbiol 2012; 30(1): 30–33 https://doi.org/10.4103/0255-0857.93017
pmid: 22361757
10
RJ Hassing, WH Goessens, W van Pelt, DJ Mevius, BH Stricker, N Molhoek, A Verbon, PJ van Genderen. Salmonella subtypes with increased MICs for azithromycin in travelers returned to The Netherlands. Emerg Infect Dis 2014; 20(4): 705–708 https://doi.org/10.3201/eid2004.131536
pmid: 24655478
11
S Das, S Samajpati, U Ray, I Roy, S Dutta. Antimicrobial resistance and molecular subtypes of Salmonella enterica serovar typhi isolates from Kolkata, India over a 15 years period 1998–2012. Int J Med Microbiol 2017; 307(1): 28–36 https://doi.org/10.1016/j.ijmm.2016.11.006
pmid: 27916384
12
MA El-Tayeb, ASS Ibrahim, AA Al-Salamah, KS Almaary, YB Elbadawi. Prevalence, serotyping and antimicrobials resistance mechanism of Salmonella enterica isolated from clinical and environmental samples in Saudi Arabia. Braz J Microbiol 2017; 48(3): 499–508 https://doi.org/10.1016/j.bjm.2016.09.021
pmid: 28245965
13
S Sood, A Kapil, N Dash, BK Das, V Goel, P Seth. Paratyphoid fever in India: an emerging problem. Emerg Infect Dis 1999; 5(3): 483–484 https://doi.org/10.3201/eid0503.990329
pmid: 10341194
14
SS Bhattacharya, U Dash. A sudden rise in occurrence of Salmonella paratyphi a infection in Rourkela, Orissa. Indian J Med Microbiol 2007; 25(1): 78–79 https://doi.org/10.4103/0255-0857.31077
pmid: 17377367
15
B Veeraraghavan, S Anandan, DP Muthuirulandi Sethuvel, N Puratchiveeran, K Walia, NK Devanga Ragupathi. Molecular characterization of intermediate susceptible typhoidal Salmonella to ciprofloxacin, and its impact. Mol Diagn Ther 2016; 20(3): 213–219 https://doi.org/10.1007/s40291-016-0191-6
pmid: 26951258
16
JG Frye, CR Jackson. Genetic mechanisms of antimicrobial resistance identified in Salmonella enterica, Escherichia coli, and Enteroccocus spp. isolated from U.S. food animals. Front Microbiol 2013; 4(4): 135 https://doi.org/10.3389/fmicb.2013.00135
pmid: 23734150
17
A Bertolini, M Castelli, S Genedani, M Garuti. Trimethoprim enhances the antibacterial activity of nalidixic and oxolinic acids and delays the emergence of resistance. Experientia 1980; 36(2): 243–244 https://doi.org/10.1007/BF01953757
pmid: 7371772
18
N Datta, H Richards, C Datta. Salmonella typhi in vivo acquires resistance to both chloramphenicol and co-trimoxazole. Lancet 1981; 317(8231): 1181–1183 https://doi.org/10.1016/s0140-6736(81)92350-3
19
S Mandal, MD Mandal, NK Pal. Synergism of ciprofloxacin and trimethoprim against Salmonella enterica serovar typhi isolates showing reduced susceptibility to ciprofloxacin. Chemotherapy 2004; 50(3): 152–154 https://doi.org/10.1159/000077890
pmid: 15272228
20
OC Amira, NU Okubadejo. Frequency of complementary and alternative medicine utilization in hypertensive patients attending an urban tertiary care centre in Nigeria. BMC Complement Altern Med 2007; 7: 30 https://doi.org/10.1186/1472-6882-7-30
pmid: 17903257
21
WH Lewis, MP Elvin-Lewis. Medicinal plants as sources of new therapeutics. Ann Mo Bot Gard 1995; 82(1): 16–24 https://doi.org/10.2307/2399976
22
F Guilhelmelli, N Vilela, P Albuquerque, LS Derengowski, I Silva-Pereira, CM Kyaw. Antibiotic development challenges: the various mechanisms of action of antimicrobial peptides and of bacterial resistance. Front Microbiol 2013; 4: 353 https://doi.org/10.3389/fmicb.2013.00353
pmid: 24367355
H Ugboko, N De. Mechanisms of antibiotic resistance in Salmonella typhi. Int J Curr Microbiol Appl Sci 2014; 3: 461–476
25
K Nishino, E Nikaido, A Yamaguchi. Regulation and physiological function of multidrug efflux pumps in Escherichia coli and Salmonella. Biochim Biophys Acta 2009; 1794(5): 834–843 https://doi.org/10.1016/j.bbapap.2009.02.002
pmid: 19230852
26
A Shaheen, F Ismat, M Iqbal, A Haque, R De Zorzi, O Mirza, T Walz, M Rahman. Characterization of putative multidrug resistance transporters of the major facilitator-superfamily expressed in Salmonellatyphi. J Infect Chemother 2015; 21(5): 357–362 https://doi.org/10.1016/j.jiac.2015.01.002
pmid: 25724589
27
E van Duijkeren, AK Schink, MC Roberts, Y Wang, S Schwarz. Mechanisms of bacterial resistance to antimicrobial agents. Microbiol Spectr 2018; 6(1): 10
pmid: 29327680
28
V Sharma, S Dahiya, P Jangra, BK Das, R Kumar, S Sood, A Kapil. Study of the role of efflux pump in ciprofloxacin resistance in Salmonella enterica serotype typhi. Indian J Med Microbiol 2013; 31(4): 374–378 https://doi.org/10.4103/0255-0857.118898
pmid: 24064645
29
SI Miller. Antibiotic resistance and regulation of the Gram-negative bacterial outer membrane barrier by host innate immune molecules. MBio 2016; 7(5): e01541–e16 https://doi.org/10.1128/mBio.01541-16
pmid: 27677793
VK Mutalik, G Nonaka, SE Ades, VA Rhodius, CA Gross. Promoter strength properties of the complete sigma E regulon of Escherichia coli and Salmonella enterica. J Bacteriol 2009; 191(23): 7279–7287 https://doi.org/10.1128/JB.01047-09
pmid: 19783623
32
X Xie, H Zhang, Y Zheng, A Li, M Wang, H Zhou, X Zhu, Z Schneider, L Chen, BN Kreiswirth, H Du. RpoE is a putative antibiotic resistance regulator of Salmonella enteric serovar typhi. Curr Microbiol 2016; 72(4): 457–464 https://doi.org/10.1007/s00284-015-0983-7
pmid: 26742769
33
H Du, M Wang, Z Luo, B Ni, F Wang, Y Meng, S Xu, X Huang. Coregulation of gene expression by sigma factors RpoE and RpoS in Salmonella enterica serovar typhi during hyperosmotic stress. Curr Microbiol 2011; 62(5): 1483–1489 https://doi.org/10.1007/s00284-011-9890-8
pmid: 21311887
M Hébrard, JPM Viala, S Méresse, F Barras, L Aussel. Redundant hydrogen peroxide scavengers contribute to Salmonella virulence and oxidative stress resistance. J Bacteriol 2009; 191(14): 4605–4614 https://doi.org/10.1128/JB.00144-09
pmid: 19447905
VK Wong, S Baker, DJ Pickard, J Parkhill, AJ Page, NA Feasey, RA Kingsley, NR Thomson, JA Keane, FX Weill, DJ Edwards, J Hawkey, SR Harris, AE Mather, AK Cain, J Hadfield, PJ Hart, NT Thieu, EJ Klemm, DA Glinos, RF Breiman, CH Watson, S Kariuki, MA Gordon, RS Heyderman, C Okoro, J Jacobs, O Lunguya, WJ Edmunds, C Msefula, JA Chabalgoity, M Kama, K Jenkins, S Dutta, F Marks, J Campos, C Thompson, S Obaro, CA MacLennan, C Dolecek, KH Keddy, AM Smith, CM Parry, A Karkey, EK Mulholland, JI Campbell, S Dongol, B Basnyat, M Dufour, D Bandaranayake, TT Naseri, SP Singh, M Hatta, P Newton, RS Onsare, L Isaia, D Dance, V Davong, G Thwaites, L Wijedoru, JA Crump, E De Pinna, S Nair, EJ Nilles, DP Thanh, P Turner, S Soeng, M Valcanis, J Powling, K Dimovski, G Hogg, J Farrar, KE Holt, G Dougan. Phylogeographical analysis of the dominant multidrug-resistant H58 clade of Salmonellatyphi identifies inter- and intracontinental transmission events. Nat Genet 2015; 47(6): 632–639 https://doi.org/10.1038/ng.3281
pmid: 25961941
38
H Pai, JH Byeon, S Yu, BK Lee, S Kim. Salmonella enterica serovar typhi strains isolated in Korea containing a multidrug resistance class 1 integron. Antimicrob Agents Chemother 2003; 47(6): 2006–2008 https://doi.org/10.1128/AAC.47.6.2006-2008.2003
pmid: 12760886
39
Y Pfeifer, J Matten, W Rabsch. Salmonella enterica serovar typhi with CTX-M β-lactamase, Germany. Emerg Infect Dis 2009; 15(9): 1533–1535 https://doi.org/10.3201/eid1509.090567
pmid: 19788837
40
SK Sy, L Zhuang, H Derendorf. Pharmacokinetics and pharmacodynamics in antibiotic dose optimization. Expert Opin Drug Metab Toxicol 2016; 12(1): 93–114 https://doi.org/10.1517/17425255.2016.1123250
pmid: 26652832
41
E Asín-Prieto, A Rodríguez-Gascón, A Isla. Applications of the pharmacokinetic/pharmacodynamic (PK/PD) analysis of antimicrobial agents. J Infect Chemother 2015; 21(5): 319–329 https://doi.org/10.1016/j.jiac.2015.02.001
pmid: 25737147
42
PG Ambrose, SM Bhavnani, CM Rubino, A Louie, T Gumbo, A Forrest, GL Drusano. Pharmacokinetics-pharmacodynamics of antimicrobial therapy: it’s not just for mice anymore. Clin Infect Dis 2007; 44(1): 79–86 https://doi.org/10.1086/510079
pmid: 17143821
43
J Li, H Hao, G Cheng, X Wang, S Ahmed, MAB Shabbir, Z Liu, M Dai, Z Yuan. The effects of different enrofloxacin dosages on clinical efficacy and resistance development in chickens experimentally infected with Salmonellatyphimurium. Sci Rep 2017; 7(1): 11676 https://doi.org/10.1038/s41598-017-12294-7
pmid: 28916830
44
SJ Lee, EG Awji, NH Park, SC Park. Using in vitro dynamic models to evaluate fluoroquinolone activity against emergence of resistant Salmonella enterica serovar typhimurium. Antimicrob Agents Chemother 2017; 61(2): e01756-16 https://doi.org/10.1128/AAC.01756-16
pmid: 27895011
45
PL Toutain, JR del Castillo, A Bousquet-Mélou. The pharmacokinetic-pharmacodynamic approach to a rational dosage regimen for antibiotics. Res Vet Sci 2002; 73(2): 105–114 https://doi.org/10.1016/S0034-5288(02)00039-5
pmid: 12204627
46
M Song, M Husain, J Jones-Carson, L Liu, CA Henard, A Vázquez-Torres. Low-molecular-weight thiol-dependent antioxidant and antinitrosative defences in Salmonella pathogenesis. Mol Microbiol 2013; 87(3): 609–622 https://doi.org/10.1111/mmi.12119
pmid: 23217033
47
M Song, JS Kim, L Liu, M Husain, A Vázquez-Torres. Antioxidant defense by thioredoxin can occur independently of canonical thiol-disulfide oxidoreductase enzymatic activity. Cell Rep 2016; 14(12): 2901–2911 https://doi.org/10.1016/j.celrep.2016.02.066
pmid: 26997275