Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma

doi:10.1007/s11684-022-0956-8

Frontiers of Medicine

2023, Vol. 17

Issue (2): 290-303 https://doi.org/10.1007/s11684-022-0956-8

本期目录

Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma

Yubing Zhou^1,², Xinyu He^1,², Yanan Jiang^1,^2,^3,⁴, Zitong Wang¹, Yin Yu^1,², Wenjie Wu^1,², Chenyang Zhang¹, Jincheng Li¹, Yaping Guo^1,³, Xinhuan Chen^1,³, Zhicai Liu^4,⁶, Jimin Zhao^1,^3,^4,⁵, Kangdong Liu^1,^2,^3,^4,⁵(

), Zigang Dong^1,^2,^3,⁵(

)

¹. The Pathophysiology Department, School of Basic Medical Sciences, Academy of Medical Sciences, Zhengzhou University, Zhengzhou 450000, China
². The China-US (Henan) Hormel Cancer Institute, Zhengzhou 450000, China
³. State Key Laboratory of Esophageal Cancer Prevention and Treatment, Zhengzhou 450000, China
⁴. Provincial Cooperative Innovation Center for Cancer Chemoprevention, Zhengzhou University, Zhengzhou 450000, China
⁵. Cancer Chemoprevention International Collaboration Laboratory, Zhengzhou 450000, China
⁶. Oncology Department, The Tumor Hospital of Linzhou City, Linzhou 456500, China

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Abstract：

Esophageal squamous cell carcinoma (ESCC) is one of the leading causes of cancer death worldwide. It is urgent to develop new drugs to improve the prognosis of ESCC patients. Here, we found benzydamine, a locally acting non-steroidal anti-inflammatory drug, had potent cytotoxic effect on ESCC cells. Benzydamine could suppress ESCC proliferation in vivo and in vitro. In terms of mechanism, CDK2 was identified as a target of benzydamine by molecular docking, pull-down assay and in vitro kinase assay. Specifically, benzydamine inhibited the growth of ESCC cells by inhibiting CDK2 activity and affecting downstream phosphorylation of MCM2, c-Myc and Rb, resulting in cell cycle arrest. Our study illustrates that benzydamine inhibits the growth of ESCC cells by downregulating the CDK2 pathway.

Key words： benzydamine cyclin-dependent kinase 2 patient-derived xenograft esophageal squamous cell carcinoma

收稿日期: 2021-12-07 出版日期: 2023-05-26

Corresponding Author(s): Kangdong Liu,Zigang Dong

引用本文:

. [J]. Frontiers of Medicine, 2023, 17(2): 290-303.
Yubing Zhou, Xinyu He, Yanan Jiang, Zitong Wang, Yin Yu, Wenjie Wu, Chenyang Zhang, Jincheng Li, Yaping Guo, Xinhuan Chen, Zhicai Liu, Jimin Zhao, Kangdong Liu, Zigang Dong. Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma. Front. Med., 2023, 17(2): 290-303.

链接本文:

https://academic.hep.com.cn/fmd/CN/10.1007/s11684-022-0956-8
https://academic.hep.com.cn/fmd/CN/Y2023/V17/I2/290

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