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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

邮发代号 80-967

2019 Impact Factor: 3.421

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Frontiers of Medicine  2023, Vol. 17 Issue (5): 993-1005   https://doi.org/10.1007/s11684-023-0989-7
  本期目录
Discovery of the mechanisms of acupuncture in the treatment of migraine based on functional magnetic resonance imaging and omics
Chong Li1, Xinyi Li1, Ke He1, Yang Wu1, Xiaoming Xie1, Jiju Yang1, Fan Zhang1, Yang Yue1, Huifeng Hao2, Shaokun Zhao3, Xin Li3, Guihua Tian1()
1. Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
2. Department of Integration of Chinese and Western Medicine, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing 100142, China
3. State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China
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Abstract：

Migraine is one of the most prevalent and disabling neurological disease, but the current pharmacotherapies show limited efficacy and often accompanied by adverse effects. Acupuncture is a promising complementary therapy, but further clinical evidence is needed. The influence of acupuncture on migraine is not an immediate effect, and its mechanism remains unclear. This study aims to provide further clinical evidence for the anti-migraine effects of acupuncture and explore the mechanism involved. A randomized controlled trial was performed among 10 normal controls and 38 migraineurs. The migraineurs were divided into blank control, sham acupuncture, and acupuncture groups. Patients were subjected to two courses of treatment, and each treatment lasted for 5 days, with an interval of 1 day between the two courses. The effectiveness of treatment was evaluated using pain questionnaire. The functional magnetic resonance imaging (fMRI) data were analyzed for investigating brain changes induced by treatments. Blood plasma was collected for metabolomics and proteomics studies. Correlation and mediation analyses were performed to investigate the interaction between clinical, fMRI and omics changes. Results showed that acupuncture effectively relieved migraine symptoms in a way different from sham acupuncture in terms of curative effect, affected brain regions, and signaling pathways. The anti-migraine mechanism involves a complex network related to the regulation of the response to hypoxic stress, reversal of brain energy imbalance, and regulation of inflammation. The brain regions of migraineurs affected by acupuncture include the lingual gyrus, default mode network, and cerebellum. The effect of acupuncture on patients’ metabolites/proteins may precede that of the brain.
Key words： acupuncture    migraine    fMRI    metabolome    proteome
收稿日期: 2022-09-19      出版日期: 2023-12-07
Corresponding Author(s): Guihua Tian   
 引用本文:   
. [J]. Frontiers of Medicine, 2023, 17(5): 993-1005.
Chong Li, Xinyi Li, Ke He, Yang Wu, Xiaoming Xie, Jiju Yang, Fan Zhang, Yang Yue, Huifeng Hao, Shaokun Zhao, Xin Li, Guihua Tian. Discovery of the mechanisms of acupuncture in the treatment of migraine based on functional magnetic resonance imaging and omics. Front. Med., 2023, 17(5): 993-1005.
 链接本文:  
https://academic.hep.com.cn/fmd/CN/10.1007/s11684-023-0989-7
https://academic.hep.com.cn/fmd/CN/Y2023/V17/I5/993
Fig.1  
Characteristics of study participants at baseline
Normal control(n = 10) Blank control(n = 13) Sham acupuncture(n = 13) Acupuncture(n = 12)
Age, mean (SD), y 30.4 (7.2) 38.5 (8.6) 38.0 (10.4) 36.1 (10.5)
Female, n (%) 7 (70) 5 (38) 8(52) 9 (75)
Male, n (%) 3 (30) 8 (62) 5 (38) 3 (25)
Age at migraine diagnosis, mean (SD), y Null 24.8 (10.9) 23.6 (11.6) 26.8 (11.1)
Duration of migraine diagnosis, mean (SD), y Null 13.7 (9.4) 14.4 (8.3) 9.3 (6.9)
Health status, mean (SD) Null 3.2 (0.8) 2.8 (1.0) 3.1 (0.6)
Concomitant medications using during study, n (%) Null 6 (46) 7 (54) 7 (58)
VAS, mean (SD) Null 6.5 (1.3) 7.0 (1.6) 7.0 (1.4)
Attack frequency, mean (SD), w Null 1.9 (0.8) 1.1 (0.5) 2.1 (1.8)
PSQI, mean (SD) Null 8.8 (4.2) 6.5 (2.6) 9.2 (2.6)
GAD, mean (SD) Null 6.8 (6.6) 4.1 (2.7) 2.3 (2.6)
MSQ total, mean (SD) Null 30.9 (19.5) 26.9 (17.4) 27.3 (21.1)
Role function-restrictive, mean (SD) Null 19.5 (9.7) 18.4 (11.0) 16.0 (9.7)
Role function-preventive, mean (SD) Null 6.1 (6.2) 6.4 (7.8) 6.0 (7.6)
Emotional function, mean (SD) Null 5.3 (5.3) 4.5 (3.2) 5.3 (5.2)
Efficacy outcomes
Blank control (n = 9) Sham acupuncture (n = 9) Acupuncture (n = 10) S0 d vs A0 d S0 d vs S10 d A0 d vs A10 d S10 d vs A10 d B0 d vs B10 d
VAS, mean (SD) 6.4 (1.1) 3.4 (2.3) 2.4 (2.1) — * * — —
Attack frequency, mean (SD), w 1.9 (1.4) 1.2 (0.8) 1.5 (21) — — — — —
PSQI, mean (SD) 7.9 (4.2) 4.3 (2.5) 6.3(1.7) — — * — —
GAD, mean (SD) 4.3 (3.6) 1.8 (2.4) 1.7 (2.1) — — — — —
MSQ total, mean (SD) 22. 8 (21.1) 14.4 (11.8) 5.5 (6.7) — — * * —
Role function-restrictive, mean (SD) 14.3 (11.2) 9.2 (5.7) 3.9 (5.2) — — * * —
Role function-preventive, mean (SD) 3.8 (6.1) 3.1 (4.9) 0.6 (1.3) — — * * —
Emotional function, mean (SD) 4.7 (5.2) 2.1 (3.0) 1.0 (1.6) — — * * —
Adverse events None None None Null Null Null Null Null
Tab.1  
Fig.2  
Fig.3  
Fig.4  
Fig.5  
Fig.6  
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