Phase separation in cGAS-STING signaling

doi:10.1007/s11684-023-1026-6

Frontiers of Medicine

2023, Vol. 17

Issue (5): 855-866 https://doi.org/10.1007/s11684-023-1026-6

本期目录

Phase separation in cGAS-STING signaling

Quanjin Li(

), Pu Gao(

)

CAS Key Laboratory of Infection and Immunity, National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China

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Abstract：

Biomolecular condensates formed by phase separation are widespread and play critical roles in many physiological and pathological processes. cGAS-STING signaling functions to detect aberrant DNA signals to initiate anti-infection defense and antitumor immunity. At the same time, cGAS-STING signaling must be carefully regulated to maintain immune homeostasis. Interestingly, exciting recent studies have reported that biomolecular phase separation exists and plays important roles in different steps of cGAS-STING signaling, including cGAS condensates, STING condensates, and IRF3 condensates. In addition, several intracellular and extracellular factors have been proposed to modulate the condensates in cGAS-STING signaling. These studies reveal novel activation and regulation mechanisms of cGAS-STING signaling and provide new opportunities for drug discovery. Here, we summarize recent advances in the phase separation of cGAS-STING signaling and the development of potential drugs targeting these innate immune condensates.

Key words： biomolecular condensates phase separation cGAS-STING pathway cGAS STING cGAMP interferon

收稿日期: 2023-04-18 出版日期: 2023-12-07

Corresponding Author(s): Quanjin Li,Pu Gao

引用本文:

. [J]. Frontiers of Medicine, 2023, 17(5): 855-866.
Quanjin Li, Pu Gao. Phase separation in cGAS-STING signaling. Front. Med., 2023, 17(5): 855-866.

链接本文:

https://academic.hep.com.cn/fmd/CN/10.1007/s11684-023-1026-6
https://academic.hep.com.cn/fmd/CN/Y2023/V17/I5/855

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