In vivo volumetric monitoring of revascularization of traumatized skin using extended depth-of-field photoacoustic microscopy

doi:10.1007/s12200-020-1040-0

Frontiers of Optoelectronics

2020, Vol. 13

Issue (4): 307-317 https://doi.org/10.1007/s12200-020-1040-0

本期目录

In vivo volumetric monitoring of revascularization of traumatized skin using extended depth-of-field photoacoustic microscopy

Zhongwen CHENG¹, Haigang MA², Zhiyang WANG², Sihua YANG^1,²(

)

¹. MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China
². Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China

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Abstract：

Faster and better wound healing is a critical medical issue. Because the repair process of wounds is closely related to revascularization, accurate early assessment and postoperative monitoring are very important for establishing an optimal treatment plan. Herein, we present an extended depth-of-field photoacoustic microscopy system (E-DOF-PAM) that can achieve a constant spatial resolution and relatively uniform excitation efficiency over a long axial range. The superior performance of the system was verified by phantom and in vivo experiments. Furthermore, the system was applied to the imaging of normal and trauma sites of volunteers, and the experimental results accurately revealed the morphological differences between the normal and traumatized skin of the epidermis and dermis. These results demonstrated that the E-DOF-PAM is a powerful tool for observing and understanding the pathophysiology of cutaneous wound healing.

Key words： photoacoustic microscopy (PAM) extended depth-of-field traumatized skin

收稿日期: 2020-04-19 出版日期: 2020-12-31

Corresponding Author(s): Sihua YANG

引用本文:

. [J]. Frontiers of Optoelectronics, 2020, 13(4): 307-317.
Zhongwen CHENG, Haigang MA, Zhiyang WANG, Sihua YANG. In vivo volumetric monitoring of revascularization of traumatized skin using extended depth-of-field photoacoustic microscopy. Front. Optoelectron., 2020, 13(4): 307-317.

链接本文:

https://academic.hep.com.cn/foe/CN/10.1007/s12200-020-1040-0
https://academic.hep.com.cn/foe/CN/Y2020/V13/I4/307

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