In vivo study of degradable magnesium and magnesium alloy as bone implant
In vivo study of degradable magnesium and magnesium alloy as bone implant
HUANG Jingjing1, REN Yibin2, ZHANG Bingchun2, YANG Ke2, JIANG Yue3
1.Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China; Graduate School of Chinese Academy of Sciences, Beijing 100049, China; 2.Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China; 3.The People′s Hospital of Liaoning Province, Shenyang 110016, China;
Abstract：In order to investigate the in vivo behavior of pure magnesium and AZ31B and the influence of mineralization induction ability, sample rods were implanted intramedullary into the femora of rabbits. After one and nine weeks, six animals from each group were sacrificed, respectively. Undecalcified cross-sections of implant were performed to observe bone-implant by scanning electron microscopy (SEM) and energy dispersive spectromicroscopy (EDS). The SEM/EDS evaluation showed that there is a thin layer of bone around magnesium and its alloy after nine-week implantation. The results further showed that the aluminum-zinc containing magnesium alloys AZ31B provided a slower degradation rate in vivo than the pure magnesium. At the locations where magnesium was resorbed, the deposition of new bone was found. The results indicate that magnesium is biocompatible, osteo-conductive and is a potential material for use as a degradable bone implant.
出版日期: 2007-12-05
引用本文:
. In vivo study of degradable magnesium and magnesium alloy as bone implant[J]. Frontiers of Materials Science in China, 2007, 1(4): 405-409.
HUANG Jingjing, REN Yibin, ZHANG Bingchun, YANG Ke, JIANG Yue. In vivo study of degradable magnesium and magnesium alloy as bone implant. Front. Mater. Sci., 2007, 1(4): 405-409.
