Release of lysozyme from electrospun PVA/lysozyme-gelatin
scaffolds
Release of lysozyme from electrospun PVA/lysozyme-gelatin
scaffolds
YANG Dong-zhi, LONG Yu-hua, NIE Jun
Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer Materials, State Key Laboratory of Chemical Resource Engineering, College of Materials Science and Engineering, Beijing University of Chemical Technology
Abstract：This article describes an electrospinning process in fabricating ultra fine fibers with core-shell structure. A biodegradable polymer, poly(vinyl alcohol) (PVA), was used as the shell; lysozyme was a kind of antioxidant; and gelatin were used as the core. Morphology and microstructure of the ultra fine fibers were characterized by scanning electron microscope (SEM), transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS) analysis. As a comparison, composite nanofiber PVA/lysozyme-gelatin blend was prepared by a normal electrospinning process. In vitro drug release behaviors of the nanofibrous membranes were determined in phosphate-buffered saline (PBS) solution. It was found that core-shell nanofibers PVA/lysozyme-gelatin obviously exhibit higher initial release rates compared to that of PVA/lysozyme-gelatin blend nanofibers. The current method may find wide application in controlled release of bioactive proteins and tissue engineering.
出版日期: 2008-09-05
引用本文:
. Release of lysozyme from electrospun PVA/lysozyme-gelatin
scaffolds[J]. Frontiers of Materials Science in China - Selected Publications from Chinese Universities, 2008, 2(3): 261-265.
YANG Dong-zhi, LONG Yu-hua, NIE Jun. Release of lysozyme from electrospun PVA/lysozyme-gelatin
scaffolds. Front. Mater. Sci., 2008, 2(3): 261-265.
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