Synthesis and thermal stability of selenium-doped hydroxyapatite with different substitutions
Yonghui LIU1,Jun MA1,2,Shengmin ZHANG1,2,*()
1. Advanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan 430074, China 2. Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China
Selenium (Se) plays a specific role in human health, especially for its anti-tumor effect. Incorporation of selenium into biocompatible hydroxyapatite (HAP) may endow the materials with novel characteristics. In the current work, a series of selenium-doped hydroxyapatite (Se-HAP) nanoparticles with different Se/P ratios were synthesized by a modified chemical precipitation. It was revealed that the powders with/without heat-treatment were nano-sized needle-like HAP while the heat-treated samples have high crystallinity. The addition of selenium decreases the crystallinity of the synthesized apatite, and also takes a negative effect on the thermal stability of the as-prepared powders. The Se-HAP nanoparticles with Se/P molar ratio not more than 5% sintered at 900°C can achieve good crystallinity and thermal stability.
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