Binary phase solid-state photopolymerization of acrylates: design, characterization and biomineralization of 3D scaffolds for tissue engineering

doi:10.1007/s11706-017-0394-8

Frontiers of Materials Science

2017, Vol. 11

Issue (4): 307-317 https://doi.org/10.1007/s11706-017-0394-8

本期目录

Binary phase solid-state photopolymerization of acrylates: design, characterization and biomineralization of 3D scaffolds for tissue engineering

Inamullah MAITLO, Safdar ALI, Muhammad Yasir AKRAM, Farooq Khurum SHEHZAD, Jun NIE(

)

State Key Laboratory of Chemical Resource Engineering & Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, China

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Abstract：

Porous polymer scaffolds designed by the cryogel method are attractive materials for a range of tissue engineering applications. However, the use of toxic cross-linker for retaining the pore structure limits their clinical applications. In this research, acrylates (HEA/PEGDA, HEMA/PEGDA and PEGDA) were used in the low-temperature soli d-state photopolymerization to produce porous scaffolds with good structural retention. The morphology, pore diameter, mineral deposition and water absorption of the scaffold were characterized by SEM and water absorption test respectively. Elemental analysis and cytotoxicity of the biomineralized scaffold were revealed by using XRD and MTT assay test. The PEGDA-derived scaffold showed good water absorption ability and a higher degree of porosity with larger pore size compared to others. XRD patterns and IR results confirmed the formation of hydroxyapatite crystals from an alternative socking process. The overall cell proliferation was excellent, where PEGDA-derived scaffold had the highest and the most uniform cell growth, while HEMA/PEGDA scaffold showed the least. These results suggest that the cell proliferation and adhesion are directly proportional to the pore size, the shape and the porosity of scaffolds.

Key words： binary phase solid-state photopolymerization phase separation tissue engineering biomineralization MTT

收稿日期: 2017-06-13 出版日期: 2017-11-29

Corresponding Author(s): Jun NIE

引用本文:

. [J]. Frontiers of Materials Science, 2017, 11(4): 307-317.
Inamullah MAITLO, Safdar ALI, Muhammad Yasir AKRAM, Farooq Khurum SHEHZAD, Jun NIE. Binary phase solid-state photopolymerization of acrylates: design, characterization and biomineralization of 3D scaffolds for tissue engineering. Front. Mater. Sci., 2017, 11(4): 307-317.

链接本文:

https://academic.hep.com.cn/foms/CN/10.1007/s11706-017-0394-8
https://academic.hep.com.cn/foms/CN/Y2017/V11/I4/307

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