Injectable hydrogel wound dressing based on strontium ion cross-linked starch
Yuxuan MAO1, Mingming PAN2, Huilin YANG2, Xiao LIN1,2(), Lei YANG1,2,3()
1. College of Chemistry, Chemical Engineering and Materials Science, Orthopaedic Institute, Soochow University, Suzhou 215006, China 2. Department of Orthopaedics, The First Affiliated Hospital, Soochow University, Suzhou 215006, China 3. Center for Health Science and Engineering, School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300131, China
Severe skin wounds cause great problems and sufferings to patients. In this study, an injectable wound dressing based on strontium ion cross-linked starch hydrogel (SSH) was developed and evaluated. The good inject-ability of SSH made it easy to be delivered onto the wound surface. The good tissue adhesiveness of SSH ensured a firm protection of the wound. Besides, SSH supported the proliferation of NIH/3T3 fibroblasts and facilitated the migration of human umbilical vein endothelial cells (HUVECs). Importantly, SSH exhibited strong antibacterial effects on Staphylococcus aureus (S. aureus), which could prevent wound infection. These results demonstrate that SSH is a promising wound dressing material for promoting wound healing.
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