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Frontiers of Materials Science

ISSN 2095-025X

ISSN 2095-0268(Online)

CN 11-5985/TB

邮发代号 80-974

2019 Impact Factor: 1.747

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Frontiers of Materials Science  2020, Vol. 14 Issue (4): 353-372   https://doi.org/10.1007/s11706-020-0530-8
  本期目录
A review on graphene-based materials as versatile cancer biomarker sensors
Shalmali BASU, Kamalika SEN()
Department of Chemistry, University of Calcutta, 92 APC Road, Kolkata 700009, India
 全文: PDF(420 KB)   HTML
Abstract：

Early detection of cancer has multitude of advantages like early diagnosis, reduced risk, ease in the treatment and follow up of recurrence. New and developed techniques are always under research to control the spreading malignancy. Graphene is an emerging star in biomedical field as it exhibits exceptional thermal, electrical and optical properties. Here, we review application of graphene-based materials in developing biosensing devices for the detection of different cancer biomarkers at concentrations down to sub-toxic levels. Different analytical methodologies chosen for sensing have been undertaken and their performance and background have been discussed. The trend of use of these methodologies can also be perceived from the graphical data presented.
Key words： graphene    cancer biomarker    biosensing    analytical methods
收稿日期: 2020-07-20      出版日期: 2020-12-09
Corresponding Author(s): Kamalika SEN   
 引用本文:   
. [J]. Frontiers of Materials Science, 2020, 14(4): 353-372.
Shalmali BASU, Kamalika SEN. A review on graphene-based materials as versatile cancer biomarker sensors. Front. Mater. Sci., 2020, 14(4): 353-372.
 链接本文:  
https://academic.hep.com.cn/foms/CN/10.1007/s11706-020-0530-8
https://academic.hep.com.cn/foms/CN/Y2020/V14/I4/353
Fig.1  
Fig.2  
Graphene material Type of cancer/cell Analyte Detection method LOD Ref.
Ag-rGO/CysA-AuNPs breast cancer CA15-3 ChA 15 U·mL−1 [32]
Ag-TiO2/rGO colorectal cancer CEA stochastic mode, DPV 20.5 fg·mL−1 [33]
Amino FG-THI-AuNPs colon cancer CEA DPV 2 pg·mL−1 [34]
lung cancer NSE 10 pg·mL−1
Au-GO breast cancer ErbB2 amperometry 0.001 pmol·L−1 [35]
Au/MnO2/ErGO/CF cervical cancer H2O2 amperometry 2 mmol·L−1 [36]
AuNFs/IL-GFW breast cancer H2O2 amperometry 100 nmol·L−1 [37]
AuNPs/Fc-ErGO breast cancer CA15-3 DPVa) 0.015 U·mL−1 [38]
AuNPs-GO breast cancer ErbB2 amperometry 0.16 nmol·L−1 [39]
CD24 0.23 nmol·L−1
AuNPs/GO-MWCNTs/GCE yolk sac, hepatocellular, liver metastasis from gastric cancer, nasopharyngeal, testicular cancer AFP DPV 3 pg·mL−1 [40]
AuPtPd/rGO breast cancer H2O2 amperometry 2 nmol·L−1 [30]
Au-TH-Gr-TH-Au testicular cancer AFP CV 0.05 ng·mL−1 [41]
Au-VBG/BDD colon cancer CEA DPV 0.15 pg·mL−1 [42]
ovarian cancer CA125 0.09 mU·mL−1
CGS-TB/PB colon cancer CEA DPV 0.1 ng·mL−1 [43]
testicular cancer AFP 0.05 ng·mL−1
CQDs@PDA@PtNCs-NG DNA damage 8-OH-dG DPV 0.45 & 0.85 µmol·L−1 [44]
CuS-rGO breast cancer CA15-3 DPV 0.3 U·mL−1 [45]
ErGO-SWCNTs breast cancer HER2 EIS 50 fg·mL−1 [46]
Fe2N NPs@rGO colon cancer, oxidative stress, etc. 4-NQO DPV 9.24 nmol·L−1 [47]
Fe3O4@GO prostate cancer PSA amperometry 15 fg·mL−1 [48]
PSMA 4.8 fg·mL−1
GF-nTiO2 breast cancer ErbB2 DPV, EIS – [31]
GNS testicular cancer AFP DPV 0.5 pg·mL−1 [49]
colon cancer CEA 0.8 pg·mL−1
breast/prostate/colorectal cancer, NSCLC uPAR CV 4.8 fmol·L−1 [50]
GO colon cancer CEA amperometry 3.2 fg·mL−1 [51]
testicular cancer AFP DPV 0.001 ng·mL−1 [52]
colon cancer CEA 0.005 ng·mL−1
ovarian cancer CA125 0.001 ng·mL−1
breast cancer CA15-3 0.005 ng·mL−1
liver cancer EpCAM, GPC3 SWV 10 cells·mL−1 [53]
prostate cancer PSA DPV 0.5 pg·mL−1 [54]
GO-Ab2 prostate cancer PSA SWV <4 ng·mL−1 [55]
GO/AuNPs prostate cancer PSA SWV 0.2b) & 0.07c) ng·mL−1 [56]
MTC calcitonin SWV 0.7 pg·mL−1 [57]
GO/AuNR breast cancer miRNA-155 DPV 0.6 fmol·L−1 [58]
GO−COOH-SPCE breast/gastric/colorectal/lung/prostate/ovarian/pancreatic/bladder carcinoma MUC1 DPV 0.04 U·mL−1 [25]
GO/ITO breast cancer CA15-3 electroreduction based redox cycling system 0.1 U·mL−1 [59]
GO-ssDNA oral cancer VEGF DPV 50 pg·mL−1 [60]
prostate cancer PSA 1 ng·mL−1
Gr-P3ABA prostate cancer PSA DPV 0.13 pg·mL−1 [61]
GQD/AuNPs/NG colon cancer CEA DPV 3.2 fg·mL−1 [62]
Gr/AuNP choroid plexus carcinoma, Wilms tumor, malignant phyllodes tumors p53 CV, EIS 0.6 fmol·L−1 [63]
Gr/AuNP/Ab-HRP metastatic HPC cells Du-145 DPV 20 cells·mL−1 [26]
Gr/MBs-Ab1/CEA/Ab2-AuNPs-HRP colon cancer CEA CV 5 ng·mL−1 [64]
Gr-modified graphite electrode CLL, AML, glioblastoma/breast/lung/prostate cancer miRNA-21 DPV, EIS 3.12 pmol [65]
GS liver/testicular cancer AFP ChA 0.03 ng·mL−1 [66]
prostate cancer TH, HRP, PSA amperometry 1 pg·mL−1 [67]
GS-CHI/SPCE testicular cancer AFP SWV, CV 0.02 ng·mL−1 [68]
MGO brain tumors, lung/breast/gastrointestinal cancer VEGF DPV 31.25 pg·mL−1 [69]
mNPs@rGO breast cancer ErbB2 EIS – [70]
ncCeO2-rGO oral cancer Cyfra-21-1 DPV 0.625 pg·mL−1 [71]
NFG/AgNPs/PANI breast cancer miRNA-21 DPV 0.2 fmol·L−1 [72]
NGQD@NC@Pd HNSs breast cancer H2O2 amperometry 20 nmol·L−1 [73]
NGS breast cancer CA15-3 CV 0.012 U·mL−1 [74]
NH2-aptamer/GO/GCE testicular cancer AFP CV 3 pg·mL−1 [75]
PANI/Gr-SPE ovarian cancer CA125 EIS 0.923 ng·μL−1 [29]
PBSE/Gr/Cu colon cancer CEA EIS 0.23 ng·mL−1 [76]
PDA-rGO colon cancer CEA amperometry 0.23 pg·mL−1 [77]
PdAuPt/COOH-rGO colon cancer CEA DPV 8 pg·mL−1 [78]
prostate cancer PSA 2 pg·mL−1
Pd@rGO/ITO prostate cancer PSA ChA 10 pg·mL−1 [28]
PP3CA/ErGO breast cancer BRCA1 DPV, EIS 3 fmol·L−1 [79]
QD-GS prostate cancer PSA SWV 3 pg·mL−1 [80]
rGO breast cancer HER2 LSV 8.5d) & 0.16e) ng·mL−1 [81]
rGO-Ag breast cancer H2O2 LSV 0.136 μmol·L−1 [82]
ChA 0.003 & 0.056f) mmol·L−1
rGO-AuNPs prostate cancer PSA SWV 2 pg·mL−1 [83]
EIS 60 pg·mL−1
rGO/ssDNA-OMC/Ni-OTC NPs lung cancer EGFR exon 21 L858R DPV 120 nmol·L−1 [84]
rGO-TEPA bladder cancer NMP22 DPV 0.01 U·mL−1 [85]
S-GS colorectal/pancreatic/gastric/bladder cancer CEA SWV 30 fg·mL−1 [86]
cervical/bladder carcinoma NMP22 25 fg·mL−1
SrGO oxidative DNA damage 8-OH-dG DPV ~1 nmol·L−1 [87]
TCPP/CCG breast/liver/lung cancer, soft tissue sarcoma, leukemia, lymphoma cyclin A2 EIS, CV 0.32 pmol·L−1 [88]
ZrO2-rGO oral cancer Cyfra-21-1 DPV 0.122 ng·mL−1 [89]
Tab.1  
Graphene material Type of cancer/cell Analyte Detection method LOD Ref.
Au-GO breast cancer ErbB2 SPR 75 & 10 pmol·L−1 [35]
prostate cancer PSA immunofluorescence analysis 0.24 fg·mL−1 [98]
GO testicular cancer AFP photometric assay – [52]
breast/liver/lung cancer, soft tissue sarcoma, leukemia, lymphoma cyclin A2 fluorescence assay 0.5 nmol·L−1 [92]
lung/breast cancer, astrocytoma, melanoma, etc. CD63, EpCAM fluorescence assay 2.1×104 particles·μL−1 [99]
breast cancer HER2 immunofluorescence analysis – [100]
nasopharyngeal carcinoma miR-205 fluorescence assay 1.18 nmol·L−1 [101]
prostate cancer PCA3 fluorescence assay 500 fmol·L−1 [102]
breast cancer SKBR3 fluorescence assay – [103]
prostate cancer LNCaP
colon cancer SW-948
GO−COOH lung cancer (NSCLC) CK19 SPR 1 fg·mL−1 [96]
GO-FLS7 CSCs CD133 fluorescence assay 7.91 nmol·L−1 [91]
GO-graphene liver cancer Hep-G2, ASGP-Rs fluorescence assay 534 cells·mL−1 [104]
GQD ovarian cancer CA125 CRET 0.05 U·mL−1 [97]
GQD-PEG-P breast/ovarian cancer miRNA-155 of A549 cells fluorescence assay – [93]
Graphene oxidative DNA damage 8-OH-dG fluorescence assay 0.1 ng·mL−1 [105]
breast cancer BRCA1, BRCA2 SPR – [95]
Graphene-coated SPR chip human epithelial-derived tumors FAP SPR 5 fmol·L−1 [106]
GRD-GOD colon cancer CEA PEC assay 5.65 fg·mL−1 [94]
N,S/GQDs liver cancer Hep G2, A549 fluorescence assay 1.19 nmol·L−1 [93]
RGD-pyrene-GO breast cancer integrin αvβ3 fluorescence assay – [34]
rGO different tumor areas PEDOT, D-PSM, CCDP/BODIPY, C/B-PgP fluorescence assay – [107]
rGO film prostate cancer PC3, 22Rv1 fluorescence assay – [108]
Tab.2  
Graphene material Type of cancer/cell Analyte LOD Ref.
CdS nanocrystals/tGO-AuNPs choroid plexus carcinoma, Wilms tumor, malignant phyllodes tumors, etc. p53 4 fg·mL−1 [111]
GNSs colon cancer CEA 0.8 pg·mL−1 [49]
testicular cancer AFP 0.5 pg·mL−1
GNSs@Fe3O4 prostate cancer PSA 0.72 pg·mL−1 [112]
Graphene-CHI/GC prostate cancer PSA 8 pg·mL−1 [110]
rGO/AuNPs-CdS:Eu QDs testicular cancer AFP 0.05 pg·mL−1 [109]
tGO colon cancer CEA 1.90 fg·mL−1 [113]
testicular cancer AFP 1.36 fg·mL−1
ZnO NPs@graphene-GOD colon cancer CEA 3.3 pg·mL−1 [114]
Tab.3  
Graphene material Type of cancer Analyte Methodology/Detection method LOD Ref.
dBSA/graphene colon cancer CEA GFET-based biosensing 337.58 fg·mL−1 [119]
GO-UCNPs pancreatic cancer IL-6 GFET-based biosensing 12 pmol·L−1 [116]
Graphene lung cancer IL-6 GFET-based biosensing 2.78 pg·mL−1 (139 fmol·L−1) [120]
PtNP/GFETs breast cancer HER3 GFET-based biosensing 300 fg·mL−1 [118]
rGO ovarian cancer CA125 GFET-based biosensing 5.0×10−10 U·mL−1 [121]
lung cancer VOCa) chemo resistive property based detection some hundreds of ppb to slightly more than a thousand hundred ppm [122]
rGO-SiO2 NPs breast cancer HER2 GFET-based biosensing 1 pmol·L−1 [117]
EGFR 100 pmol·L−1
SCG lung cancer ANXA2, ENO1, VEGF resistant shift 0.1 pg·mL−1 [69]
Tab.4  
Graphene material Type of cancer Analyte Detection method LOD Ref.
GO nanosheets colon cancer CEA potentiometry 9.4 pg·mL−1 [124]
GOs ovarian cancer carnitine potentiometry 41a) & 50b) mmol·L−1 [126]
PGOs breast cancer HeLa, A549, MDA-MB-231 LAPS-based sensing – [125]
Tab.5  
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