Synthesis of pH-responsive triazine skeleton nano-polymer composite containing AIE group for drug delivery

doi:10.1007/s11706-021-0539-7

Frontiers of Materials Science

2021, Vol. 15

Issue (1): 113-123 https://doi.org/10.1007/s11706-021-0539-7

本期目录

Synthesis of pH-responsive triazine skeleton nano-polymer composite containing AIE group for drug delivery

Yifan ZHANG¹, Xueying PENG¹, Xinbo JING¹, Lin CUI²(

), Shengchao YANG¹, Jianning WU¹, Guihua MENG¹, Zhiyong LIU¹(

), Xuhong GUO^1,³

¹. School of Chemistry and Chemical Engineering, Shihezi University/Key Laboratory of Green Process for Chemical Engineering/ Key Laboratory for Chemical Materials of Xinjiang Uygur Autonomous Region/Engineering Center for Chemical Materials of Xinjiang Bingtuan, Shihezi University, Shihezi 832003, China
². School of Medicine, Shihezi University, Shihezi 832003, China
³. State Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China

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Abstract：

We exploited a unique porous structure of the nano-covalent triazine polymer (NCTP) containing aggregation-induced emission (AIE) group to achieve controlled release and drug tracking in tumor acidic microenvironment. NCTP was synthesized by the Friedel–Crafts alkylation and the McMurry coupling reaction. It not only had strong doxorubicin (DOX)-loading capacity due to its high specific surface area and large pore volume, but also showed the significant cumulative drug release as a result of the pH response of triazine polymers. NCTP was induced luminescence after mass accumulation near tumor cells. Besides, it had excellent biocompatibility and obvious antineoplastic toxicity. The results demonstrate that NCTP as a utility-type drug carrier provides a new route for designing the multi-functional drug delivery platform.

Key words： triazine skeleton structure pH response aggregation-induced emission drug delivery

收稿日期: 2020-08-27 出版日期: 2021-03-11

Corresponding Author(s): Lin CUI,Zhiyong LIU

引用本文:

. [J]. Frontiers of Materials Science, 2021, 15(1): 113-123.
Yifan ZHANG, Xueying PENG, Xinbo JING, Lin CUI, Shengchao YANG, Jianning WU, Guihua MENG, Zhiyong LIU, Xuhong GUO. Synthesis of pH-responsive triazine skeleton nano-polymer composite containing AIE group for drug delivery. Front. Mater. Sci., 2021, 15(1): 113-123.

链接本文:

https://academic.hep.com.cn/foms/CN/10.1007/s11706-021-0539-7
https://academic.hep.com.cn/foms/CN/Y2021/V15/I1/113

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