Carbon nanotubes-reinforced polylactic acid/hydroxyapatite porous scaffolds for bone tissue engineering
Weiwei Lan1, Mingbo Wang2, Zhenjun Lv1, Jun Li1, Fuying Chen1, Ziwei Liang1,3, Di Huang1,3(), Xiaochun Wei4, Weiyi Chen1,3
1. Research Center for Nano-Biomaterials & Regenerative Medicine, Department of Biomedical Engineering, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China 2. Guangdong Engineering Technology Research Center of Implantable Medical Polymer, Shenzhen Lando Biomaterials Co., Ltd., Shenzhen 518107, China 3. Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering, Taiyuan 030060, China 4. Department of Orthopaedics, The Second Hospital of Shanxi Medical University, Taiyuan 030001, China
In the field of bone defect repair, critical requirements for favorable cytocompatibility and optimal mechanical properties have propelled research efforts towards the development of composite materials. In this study, carbon nanotubes/polylactic acid/hydroxyapatite (CNTs/PLA/HA) scaffolds with different contents (0.5, 1, 1.5 and 2 wt.%) of CNTs were prepared by the thermally induced phase separation (TIPS) method. The results revealed that the composite scaffolds had uniform pores with high porosities over 68% and high through performances. The addition of CNTs significantly enhanced the mechanical properties of resulted PLA/HA, in which the 1.5 wt.% CNTs/PLA/HA composite scaffold demonstrated the optimum mechanical behaviors with the bending elastic modulus of (868.5 ± 12.34) MPa, the tensile elastic modulus of (209.51 ± 12.73) MPa, and the tensile strength of (3.26 ± 0.61) MPa. Furthermore, L929 cells on the 1.5 wt.% CNTs/PLA/HA scaffold displayed good spreading performance and favorable cytocompatibility. Therefore, it is expected that the 1.5 wt.% CNTs/PLA/HA scaffold has potential applications in bone tissue engineering.
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