Corrosion and bone response of magnesium implants
after surface modification by heat-self-assembled monolayer
Corrosion and bone response of magnesium implants
after surface modification by heat-self-assembled monolayer
Jia-Cheng GAO1,Li-Ying QIAO1,Ren-Long XIN2,
1.National Engineering
Center for Magnesium Alloy, Chongqing University, Chongqing 400044,
China；College of Material
Science and Engineering, Chongqing University, Chongqing 400045, China; 2.College of Material
Science and Engineering, Chongqing University, Chongqing 400045, China;
Abstract：The corrosion degradation behavior and in vivo test of 4N-Mg after surface modification by heat-self-assembled monolayer (HSAM) were studied in this paper. Comprehensive techniques were used to analyze the corrosion process, corrosion rate and corrosion mecha-nism. The Mg samples with and without modifications were embedded in the thigh bones of white rabbits, and TC4 was used as the control. The concentration of Mg2+ ion in blood were analyzed after 2, 6, and 12 weeks of implantation. Then the specimens were analyzed by scanning electron microscope (SEM), and tissue slices were observed by optical microscope. The results show that the modified Mg had better corrosion resistance. The in vivo study confirmed that the magnesium concentration in blood was in the normal scale, and the Mg have good bone inducement and showed excellent capabilty of contact with bone. After implantations for a few weeks, the new bone obviously mineralizes on the interface between the modified Mg and bone. The untreated magnesium corroded faster than the HSAM treated magnesium in vivo. All the results indicated that Mg showed better biocompatibility and the capacity of inducing new bone due to HSAM had an effect on controlling the corrsion rate of Mg.
. Corrosion and bone response of magnesium implants
after surface modification by heat-self-assembled monolayer[J]. Front. Mater. Sci., 2010, 4(2): 120-125.
Jia-Cheng GAO, Li-Ying QIAO, Ren-Long XIN, . Corrosion and bone response of magnesium implants
after surface modification by heat-self-assembled monolayer. Front. Mater. Sci., 2010, 4(2): 120-125.
McBride E D. Absorbable metal in bone surgery. Journal of the American Medical Association, 1938, 111(27): 2464–2467
Znamenskii M S. Metallic osteosynthesis by means of an apparatus madeof resorbing metal. Khirurgiia, 1945, 12: 60–63
McCord C P. Chemical gas gangrene from metallic magnesium. Industrial Medicine, 1942, 1(2): 71–79
Kuwahara H, Al-Abdullat Y, Mazaki N, et al. Precipitation ofmagnesium apatite on pure magnesium surface during immersing in Hank’ssolution. Materials Transactions, 2001, 42(7): 1317–1321 doi: 10.2320/matertrans.42.1317
Li L, Gao J, Wang Y. Evaluation of cyto-toxicity and corrosionbehavior of alkali-treated magnesium in simulated body fluid. Surface and Coating Technology, 2004, 185(1): 92–98 doi: 10.1016/j.surfcoat.2004.01.004
Gao J C, Xue Y, Qiao L Y, et al. Surface modification of magnesiumwith rare earth conversion films for biomedical protection. Materials Science Forum, 2007, 546―549: 601–604
Song Y W, Shan D Y, Han E H. Electrodeposition of hydroxyapatite coatingon AZ91D magnesium alloy for biomaterial application. Materials Letters, 2008, 62(17―18): 3276–3279 doi: 10.1016/j.matlet.2008.02.048
Xu L, Pan F, Yu G, et al. In vitro and in vivo evaluation of the surface bioactivityof a calcium phosphate coated magnesium alloy. Biomaterials, 2009, 30(8): 1512–1523 doi: 10.1016/j.biomaterials.2008.12.001
Zhang E, Xu L, Yang K. Formation by ion plating of Ti-coatingon pure Mg for biomedical applications. Scripta Materialia, 2005, 53(5): 523–527 doi: 10.1016/j.scriptamat.2005.05.009
Liu C, Xin Y, Tian X, et al. Corrosion resistance of titaniumion implanted AZ91 magnesium alloy. Journal of Vacuum Science & Technology A: Vacuum, Surfaces, and Films, 2007, 25(2): 334–339 doi: 10.1116/1.2699371
Liu C, Xin Y, Tian X, et al. Corrosion behavior of AZ91 magnesiumalloy treated by plasma immersion ion implantation and depositionin artificial physiological fluids. Thin Solid Films, 2007, 516(2―4): 422–427 doi: 10.1016/j.tsf.2007.05.048
Yang J X, Cui F Z, Lee I-S, et al. Ion-beam assisted depositedC–N coating on magnesium alloys. Surface and Coatings Technology, 2008, 202(22―23): 5737–5741 doi: 10.1016/j.surfcoat.2008.06.116
Hiromoto S, Shishido T, Yamamoto A, et al. Precipitation controlof calcium phosphate on pure magnesium by anodization. Corrosion Science, 2008, 50(10): 2906–2913 doi: 10.1016/j.corsci.2008.08.013
Hu J, Guan S, Zhang C, et al. Corrosion protection of AZ31magnesium alloy by a TiO2 coating prepared by LPD method. Surface and Coatings Technology, 2009, 203(14): 2017–2020 doi: 10.1016/j.surfcoat.2009.01.036
Witte F, Kaese V, Haferkamp H, et al. In vivo corrosion of four magnesium alloys and the associated bone response. Biomaterials, 2005, 26(17): 3557–3563 doi: 10.1016/j.biomaterials.2004.09.049
Duygulu O, Kaya R A, Oktay G, et al. Investigation on thepotential of magnesium alloy AZ31 as a bone implant. Materials Science Forum, 2007, 546―549: 421–424
Huang J, Ren Y, Zhang B, et al. Study on biocompatility of magnesiumand its alloys. Rare Metal Materials andEngineering, 2007, 36(6): 1102–1105 (in Chinese)
Huang J, Yang K, Ren Y, et al. Experimental study on earlystage of mg implanted in animals. Rare Metal Materials and Engineering, 2008, 37(4): 629–632 (in Chinese)
