Functional regulation of monocyte-derived dendritic cells by microRNAs
Functional regulation of monocyte-derived dendritic cells by microRNAs
Yifan Zhan1,2(), Li Wu3
1. The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia; 2. Department of Medical Biology, University of Melbourne, Parkville 3010, Australia; 3. Tsignhua University and Peking University Joint Center for Life Sciences and Tsinghua University School of Medicine, Beijing 100084, China
Dendritic cells (DCs) as a rare type of leukocytes play an important role in bridging the innate and adaptive immune system. A subset of DCs, monocyte-derived dendritic cells (moDCs), exists in very low numbers at steady state but become abundant in inflammatory states. These inflammation-associated DCs are potent producers of pro-inflammatory cytokines and potent inducers of T helper differentiation. They behave as a “double-edge” sword so that they not only mediate protective immunity but also immuno-pathology. It is still incompletely understood how their function is regulated. Emerging evidence indicates that microRNAs (miRNAs), as a new class of gene regulators, potently regulate the function of moDCs. Here we summarize recent progress in this area.
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