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Protein & Cell

ISSN 1674-800X

ISSN 1674-8018(Online)

CN 11-5886/Q

邮发代号 80-984

2019 Impact Factor: 10.164

Protein & Cell  2014, Vol. 5 Issue (6): 411-419   https://doi.org/10.1007/s13238-014-0049-9
  本期目录
DNA replication components as regulators of epigenetic inheritance—lesson from fission yeast centromere
Haijin He1,Marlyn Gonzalez1,Fan Zhang2,Fei Li1,*()
1. Department of Biology, New York University, New York, NY 10003, USA
2. Clinical Translational Research Center, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China
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Abstract

Genetic information stored in DNA is accurately copied and transferred to subsequent generations through DNA replication. This process is accomplished through the concerted actions of highly conserved DNA replication components. Epigenetic information stored in the form of histone modifications and DNA methylation, constitutes a second layer of regulatory information important for many cellular processes, such as gene expression regulation, chromatin organization, and genome stability. During DNA replication, epigenetic information must also be faithfully transmitted to subsequent generations. How this monumental task is achieved remains poorly understood. In this review, we will discuss recent advances on the role of DNA replication components in the inheritance of epigenetic marks, with a particular focus on epigenetic regulation in fission yeast. Based on these findings, we propose that specific DNA replication components function as key regulators in the replication of epigenetic information across the genome.

Key wordsepigenetic inheritance    DNA replication    centromere    histone modification    heterochromatin    euchromatin
收稿日期: 2014-02-10      出版日期: 2014-06-25
Corresponding Author(s): Fei Li   
 引用本文:   
. [J]. Protein & Cell, 2014, 5(6): 411-419.
Haijin He,Marlyn Gonzalez,Fan Zhang,Fei Li. DNA replication components as regulators of epigenetic inheritance—lesson from fission yeast centromere. Protein Cell, 2014, 5(6): 411-419.
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https://academic.hep.com.cn/pac/CN/10.1007/s13238-014-0049-9
https://academic.hep.com.cn/pac/CN/Y2014/V5/I6/411
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