Potential coordination role between O-GlcNAcylation and epigenetics

doi:10.1007/s13238-017-0416-4

Protein & Cell

2017, Vol. 8

Issue (10): 713-723 https://doi.org/10.1007/s13238-017-0416-4

本期目录

Potential coordination role between O-GlcNAcylation and epigenetics

Donglu Wu¹, Yong Cai^1,^2,³, Jingji Jin^1,^2,³(

)

¹. School of Life Sciences, Jilin University, Changchun 130012, China
². National Engineering Laboratory for AIDS Vaccine, Jilin University, Changchun 130012, China
³. Key Laboratory for Molecular Enzymology and Engineering, The Ministry of Education, Jilin University, Changchun 130012, China

全文: PDF(858 KB)

Abstract：

Dynamic changes of the post-translational O-GlcNAc modification (O-GlcNAcylation) are controlled by O-linked β-N-acetylglucosamine (O-GlcNAc) transferase (OGT) and the glycoside hydrolase O-GlcNAcase (OGA) in cells. O-GlcNAcylation often occurs on serine (Ser) and threonine (Thr) residues of the specific substrate proteins via the addition of O-GlcNAc group by OGT. It has been known that O-GlcNAcylation is not only involved in many fundamental cellular processes, but also plays an important role in cancer development through various mechanisms. Recently, accumulating data reveal that O-GlcNAcylation at histones or non-histone proteins can lead to the start of the subsequent biological processes, suggesting that O-GlcNAcylation as ‘protein code’ or ‘histone code’ may provide recognition platforms or executive instructions for subsequent recruitment of proteins to carry out the specific functions. In this review, we summarize the interaction of O-GlcNAcylation and epigenetic changes, introduce recent research findings that link crosstalk between OGlcNAcylation and epigenetic changes, and speculate on the potential coordination role of O-GlcNAcylation with epigenetic changes in intracellular biological processes.

Key words： O-GlcNAcylation post-translational modification histone modification epigenetics

收稿日期: 2017-03-07 出版日期: 2017-11-06

Corresponding Author(s): Jingji Jin

引用本文:

. [J]. Protein & Cell, 2017, 8(10): 713-723.
Donglu Wu, Yong Cai, Jingji Jin. Potential coordination role between O-GlcNAcylation and epigenetics. Protein Cell, 2017, 8(10): 713-723.

链接本文:

https://academic.hep.com.cn/pac/CN/10.1007/s13238-017-0416-4
https://academic.hep.com.cn/pac/CN/Y2017/V8/I10/713

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