Please wait a minute...
Protein & Cell

ISSN 1674-800X

ISSN 1674-8018(Online)

CN 11-5886/Q

邮发代号 80-984

2019 Impact Factor: 10.164

Protein & Cell  2020, Vol. 11 Issue (2): 150-154   https://doi.org/10.1007/s13238-019-00672-y
  本期目录
DNMT3A reads and connects histone H3K36me2 to DNA methylation
Wenqi Xu1, Jiahui Li1, Bowen Rong11, Bin Zhao1, Mei Wang2, Ruofei Dai1, Qilong Chen3, Hang Liu1, Zhongkai Gu1, Shuxian Liu1, Rui Guo1, Hongjie Shen1(), Feizhen Wu1(), Fei Lan1()
1. Key Laboratory of Birth Defects, Children’s Hospital, Fudan University, and Key Laboratory of Epigenetics, Institutes of Biomedical Sciences, Fudan University, Shanghai 201102, China
2. Department of Geriatrics, Shanghai General Hospital, Shanghai 201103, China
3. Research Center for Chinese Traditional Medicine Complexity System, Shanghai University of Chinese Traditional Medicine, Shanghai 201203, China
 全文: PDF(701 KB)  
出版日期: 2020-03-04
Corresponding Author(s): Hongjie Shen,Feizhen Wu,Fei Lan   
 引用本文:   
. [J]. Protein & Cell, 2020, 11(2): 150-154.
Wenqi Xu, Jiahui Li, Bowen Rong1, Bin Zhao, Mei Wang, Ruofei Dai, Qilong Chen, Hang Liu, Zhongkai Gu, Shuxian Liu, Rui Guo, Hongjie Shen, Feizhen Wu, Fei Lan. DNMT3A reads and connects histone H3K36me2 to DNA methylation. Protein Cell, 2020, 11(2): 150-154.
 链接本文:  
https://academic.hep.com.cn/pac/CN/10.1007/s13238-019-00672-y
https://academic.hep.com.cn/pac/CN/Y2020/V11/I2/150
1 T Baubec, DF Colombo, C Wirbelauer, J Schmidt, L Burger, AR Krebs, A Akalin, D Schubeler (2015) Genomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation. Nature 520:243–247
https://doi.org/10.1038/nature14176
2 X Guo, L Wang, J Li, Z Ding, J Xiao, X Yin, S He, P Shi, L Dong, G Liet al. (2015) Structural insight into autoinhibition and histone H3-induced activation of DNMT3A. Nature 517:640–644
https://doi.org/10.1038/nature13899
3 R Jaenisch, A Bird (2003) Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet 33(Suppl):245–254
https://doi.org/10.1038/ng1089
4 JJ Keats, T Reiman, CA Maxwell, BJ Taylor, LM Larratt, MJ Mant, AR Belch, LM Pilarski (2003) In multiple myeloma, t(4;14)(p16; q32) is an adverse prognostic factor irrespective of FGFR3 expression. Blood 101:1520–1529
https://doi.org/10.1182/blood-2002-06-1675
5 AJ Kuo, P Cheung, K Chen, BM Zee, M Kioi, J Lauring, Y Xi, BH Park, X Shi, BA Garciaet al. (2011) NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming. Mol Cell 44:609–620
https://doi.org/10.1016/j.molcel.2011.08.042
6 BZ Li, Z Huang, QY Cui, XH Song, L Du, A Jeltsch, P Chen, G Li, E Li, GL Xu (2011) Histone tails regulate DNA methylation by allosterically activating de novo methyltransferase. Cell Res 21:1172–1181
https://doi.org/10.1038/cr.2011.92
7 M Morselli, WA Pastor, B Montanini, K Nee, R Ferrari, K Fu, G Bonora, L Rubbi, AT Clark, S Ottonelloet al. (2015) In vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse. Elife 4:e6205
https://doi.org/10.7554/eLife.06205
8 F Neri, S Rapelli, A Krepelova, D Incarnato, C Parlato, G Basile, M Maldotti, F Anselmi, S Oliviero (2017) Intragenic DNA methylation prevents spurious transcription initiation. Nature 543:72–77
https://doi.org/10.1038/nature21373
9 JA Oyer, X Huang, Y Zheng, J Shim, T Ezponda, Z Carpenter, M Allegretta, CI Okot-Kotber, JP Patel, A Melnicket al. (2014) Point mutation E1099K in MMSET/NSD2 enhances its methyltranferase activity and leads to altered global chromatin methylation in lymphoid malignancies. Leukemia 28:198–201
https://doi.org/10.1038/leu.2013.204
10 R Rosati, R La Starza, A Veronese, A Aventin, C Schwienbacher, T Vallespi, M Negrini, MF Martelli, C Mecucci (2002) NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15). Blood 99:3857–3860
https://doi.org/10.1182/blood.V99.10.3857
11 SM Sankaran, AW Wilkinson, JE Elias, O Gozani (2016) A PWWP domain of histone-lysine N-methyltransferase NSD2 binds to dimethylated Lys-36 of histone H3 and regulates NSD2 function at chromatin. J Biol Chem 291:8465–8474
https://doi.org/10.1074/jbc.M116.720748
12 M Santra, F Zhan, E Tian, B Barlogie, JJ Shaughnessy (2003) A subset of multiple myeloma harboring the t(4;14)(p16;q32) translocation lacks FGFR3 expression but maintains an IGH/MMSET fusion transcript. Blood 101:2374–2376
https://doi.org/10.1182/blood-2002-09-2801
13 ZD Smith, A Meissner (2013) DNA methylation: roles in mammalian development. Nat Rev Genet 14:204–220
https://doi.org/10.1038/nrg3354
14 GG Wang, L Cai, MP Pasillas, MP Kamps (2007) NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis. Nat Cell Biol 9:804–812
https://doi.org/10.1038/ncb1608
15 Y Zhang, R Jurkowska, S Soeroes, A Rajavelu, A Dhayalan, I Bock, P Rathert, O Brandt, R Reinhardt, W Fischleet al. (2010) Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail. Nucleic Acids Res 38:4246–4253
https://doi.org/10.1093/nar/gkq147
[1] PAC-0151-19380-LF_suppl_1 Download
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed