The potential of using blood circular RNA as liquid biopsy biomarker for human diseases
Guoxia Wen1, Tong Zhou2(), Wanjun Gu1()
1. State Key Laboratory of Bioelectronics, School of Biological Sciences and Medical Engineering, Southeast University, Nanjing 210096, China 2. Department of Physiology and Cell Biology, Reno School of Medicine, University of Nevada, Reno, NV 89557, USA
Circular RNA (circRNA) is a novel class of singlestranded RNAs with a closed loop structure. The majority of circRNAs are formed by a back-splicing process in pre-mRNA splicing. Their expression is dynamically regulated and shows spatiotemporal patterns among cell types, tissues and developmental stages. CircRNAs have important biological functions in many physiological processes, and their aberrant expression is implicated in many human diseases. Due to their high stability, circRNAs are becoming promising biomarkers in many human diseases, such as cardiovascular diseases, autoimmune diseases and human cancers. In this review, we focus on the translational potential of using human blood circRNAs as liquid biopsy biomarkers for human diseases. We highlight their abundant expression, essential biological functions and significant correlations to human diseases in various components of peripheral blood, including whole blood, blood cells and extracellular vesicles. In addition, we summarize the current knowledge of blood circRNA biomarkers for disease diagnosis or prognosis.
. [J]. Protein & Cell, 2021, 12(12): 911-946.
Guoxia Wen, Tong Zhou, Wanjun Gu. The potential of using blood circular RNA as liquid biopsy biomarker for human diseases. Protein Cell, 2021, 12(12): 911-946.
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