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Protein & Cell

ISSN 1674-800X

ISSN 1674-8018(Online)

CN 11-5886/Q

邮发代号 80-984

2019 Impact Factor: 10.164

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Protein & Cell  2023, Vol. 14 Issue (3): 165-179   https://doi.org/10.1093/procel/pwac032
  本期目录
The engagement of histone lysine methyltransferases with nucleosomes: structural basis, regulatory mechanisms, and therapeutic implications
Yanjing Li1,2(), Kexue Ge1, Tingting Li1, Run Cai1, Yong Chen1()
1. State Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
2. State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai Collaborative Innovation Center for Biomanufacturing(SCICB), Meilong Road 130, Shanghai 200237, China
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Abstract：

Histone lysine methyltransferases (HKMTs) deposit methyl groups onto lysine residues on histones and play important roles in regulating chromatin structure and gene expression. The structures and functions of HKMTs have been extensively investigated in recent decades, significantly advancing our understanding of the dynamic regulation of histone methylation. Here, we review the recent progress in structural studies of representative HKMTs in complex with nucleosomes (H3K4, H3K27, H3K36, H3K79, and H4K20 methyltransferases), with emphasis on the molecular mechanisms of nucleosome recognition and trans-histone crosstalk by these HKMTs. These structural studies inform HKMTs’ roles in tumorigenesis and provide the foundations for developing new therapeutic approaches targeting HKMTs in cancers.
Key words： nucleosome    cryo-EM structures    histone methyltransferases    epigenetics    histone methylation    tumorigenesis
收稿日期: 2022-05-08      出版日期: 2023-04-17
Corresponding Author(s): Yanjing Li,Yong Chen   
 引用本文:   
. [J]. Protein & Cell, 2023, 14(3): 165-179.
Yanjing Li, Kexue Ge, Tingting Li, Run Cai, Yong Chen. The engagement of histone lysine methyltransferases with nucleosomes: structural basis, regulatory mechanisms, and therapeutic implications. Protein Cell, 2023, 14(3): 165-179.
 链接本文:  
https://academic.hep.com.cn/pac/CN/10.1093/procel/pwac032
https://academic.hep.com.cn/pac/CN/Y2023/V14/I3/165
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