Radiation injury and gut microbiota-based treatment

doi:10.1093/procel/pwad044

Protein & Cell

2024, Vol. 15

Issue (2): 83-97 https://doi.org/10.1093/procel/pwad044

本期目录

Radiation injury and gut microbiota-based treatment

Weihong Wang^1,², Bota Cui^1,², Yongzhan Nie^3,⁴, Lijuan Sun⁵, Faming Zhang^1,^2,⁴(

)

¹. Department of Microbiota Medicine and Medical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China
². Department of Microbiotherapy, Sir Run Run Hospital, Nanjing Medical University, Nanjing 211166, China
³. State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi’an 710032, China
⁴. National Clinical Research Center for Digestive Diseases, Xi’an 710032, China
⁵. Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University, Xi’an 710069, China

全文: PDF(7959 KB)

Abstract：

The exposure to either medical sources or accidental radiation can cause varying degrees of radiation injury (RI). RI is a common disease involving multiple human body parts and organs, yet effective treatments are currently limited. Accumulating evidence suggests gut microbiota are closely associated with the development and prevention of various RI. This article summarizes 10 common types of RI and their possible mechanisms. It also highlights the changes and potential microbiota-based treatments for RI, including probiotics, metabolites, and microbiota transplantation. Additionally, a 5P-Framework is proposed to provide a comprehensive strategy for managing RI.

Key words： microbiome ionizing radiation radiation-induced injury short-chain fatty acids fecal microbiota transplant washed microbiota transplantation war nuclear microbiota medicine

收稿日期: 2023-05-15 出版日期: 2024-02-28

Corresponding Author(s): Faming Zhang

引用本文:

. [J]. Protein & Cell, 2024, 15(2): 83-97.
Weihong Wang, Bota Cui, Yongzhan Nie, Lijuan Sun, Faming Zhang. Radiation injury and gut microbiota-based treatment. Protein Cell, 2024, 15(2): 83-97.

链接本文:

https://academic.hep.com.cn/pac/CN/10.1093/procel/pwad044
https://academic.hep.com.cn/pac/CN/Y2024/V15/I2/83

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