Long way up: rethink diseases in light of phase separation and phase transition

doi:10.1093/procel/pwad057

Protein & Cell

2024, Vol. 15

Issue (7): 475-492 https://doi.org/10.1093/procel/pwad057

本期目录

Long way up: rethink diseases in light of phase separation and phase transition

Mingrui Ding^1,^2,³, Weifan Xu^1,^2,³, Gaofeng Pei^1,², Pilong Li^1,²(

)

¹. State Key Laboratory of Membrane Biology & Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, Beijing 100084, China
². Tsinghua-Peking Center for Life Sciences, Beijing 100084, China
³. NuPhase Therapeutics, Beijing 100083, China

全文: PDF(11857 KB)

Abstract：

Biomolecular condensation, driven by multivalency, serves as a fundamental mechanism within cells, facilitating the formation of distinct compartments, including membraneless organelles that play essential roles in various cellular processes. Perturbations in the delicate equilibrium of condensation, whether resulting in gain or loss of phase separation, have robustly been associated with cellular dysfunction and physiological disorders. As ongoing research endeavors wholeheartedly embrace this newly acknowledged principle, a transformative shift is occurring in our comprehension of disease. Consequently, significant strides have been made in unraveling the profound relevance and potential causal connections between abnormal phase separation and various diseases. This comprehensive review presents compelling recent evidence that highlight the intricate associations between aberrant phase separation and neurodegenerative diseases, cancers, and infectious diseases. Additionally, we provide a succinct summary of current efforts and propose innovative solutions for the development of potential therapeutics to combat the pathological consequences attributed to aberrant phase separation.

Key words： multivalency compartments aberrant phase separation therapeutics gain or loss of phase separation diseases

收稿日期: 2023-10-12 出版日期: 2024-07-31

Corresponding Author(s): Pilong Li

引用本文:

. [J]. Protein & Cell, 2024, 15(7): 475-492.
Mingrui Ding, Weifan Xu, Gaofeng Pei, Pilong Li. Long way up: rethink diseases in light of phase separation and phase transition. Protein Cell, 2024, 15(7): 475-492.

链接本文:

https://academic.hep.com.cn/pac/CN/10.1093/procel/pwad057
https://academic.hep.com.cn/pac/CN/Y2024/V15/I7/475

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