Microfluidics for cell-cell interactions: A review

doi:10.1007/s11705-015-1550-2

Front. Chem. Sci. Eng.

2016, Vol. 10

Issue (1) : 90-98 https://doi.org/10.1007/s11705-015-1550-2

REVIEW ARTICLE

Microfluidics for cell-cell interactions: A review

Rui Li,Xuefei Lv,Xingjian Zhang,Omer Saeed,Yulin Deng(

)

School of Life Science, Beijing Institute of Technology, Beijing 100081, China

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Abstract

Microfluidic chip has been applied in various biological fields owing to its low-consumption of reagents, high throughput, fluidic controllability and integrity. The well-designed microscale intermediary is also ideal for the study of cell biology. Particularly, microfluidic chip is helpful for better understanding cell-cell interactions. A general survey of recent publications would help to generalize the designs of the co-culture chips with different features. With ingenious and combinational utilization, the chips facilitate the implementation of some special co-culture models that are highly concerned in a different spatial and temporal way.

Keywords microfluidic chip co-culture cell-cell interactions review

Corresponding Author(s): Yulin Deng

Online First Date: 29 December 2015 Issue Date: 29 February 2016

Cite this article:

Omer Saeed,Rui Li,Xuefei Lv, et al. Microfluidics for cell-cell interactions: A review[J]. Front. Chem. Sci. Eng., 2016, 10(1): 90-98.

URL:

https://academic.hep.com.cn/fcse/EN/10.1007/s11705-015-1550-2
https://academic.hep.com.cn/fcse/EN/Y2016/V10/I1/90

Fig.1 Typical progress of seeding and culturing cells in 3D structure

Fig.2 Pneumatic microvalve operations for cell co-culture

Fig.3 Microchannel design for real time observation of cell-cell interaction

Fig.4 Membrane insertion between two chambers for separating and culturing cells

Tab.1 Common co-culture modes in microfluidics and their features

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