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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

Postal Subscription Code 80-967

2018 Impact Factor: 1.847

Front Med    2011, Vol. 5 Issue (1) : 45-52     DOI: 10.1007/s11684-011-0117-y
REVIEW |
Arsenic in the treatment of newly diagnosed acute promyelocytic leukemia: current status and future research direction
Jiong HU()
Department of Hematology, Rui Jin Hospital, Shanghai Institute of Hematology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
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Abstract  

Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia. In past decades, intensive studies on the biology and treatment of this disease have resulted in a remarkably thorough understanding of its pathogenesis and improvement of treatment outcomes. In particular, the introduction of all-trans retinoic acid to conventional chemotherapy improved dramatically the remission and survival rates of APL patients and consequently became the major treatment modality for it. In the last decade, the groundbreaking development of arsenic further improved the survival rate of APL patients. As the most active agent in APL, arsenic directly degrades the PML-RARα fusion transcript, leading to the differentiation and apoptosis of leukemia cells and the potential eradication of APL leukemia-initiating cells (LICs), thus making the disease a potentially curable type of leukemia. More notably, the recent development of oral arsenic compounds may further enhance not only clinical outcomes but also the convenience of patients, which may dramatically change the APL clinical scenario in the near future.

Keywords acute promyelocytic leukemia      arsenic      all-trans retinoic acid      survival     
Corresponding Authors: HU Jiong,Email:hujiong@medmail.com.cn   
Issue Date: 05 March 2011
URL:  
http://academic.hep.com.cn/fmd/EN/10.1007/s11684-011-0117-y     OR     http://academic.hep.com.cn/fmd/EN/Y2011/V5/I1/45
InductionConsolidationMaintenanceCycles of ArsenicRef.
Shanghai Institute of Hematology++621
North American Leukemia Intergroup Study+224
MD Anderson++522-23
Tab.1  Different strategies of arsenic combination with ATRA in the treatment of newly diagnosed APL
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