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Preparation, characterization and properties studies of quinine-imprinted polymer in the aqueous phase |
| He Jianfeng1, Liu Lan2, Yang Guilan2, Deng Qinying3 |
| 1.College of Pharmacy, Guangzhou University of Traditional Chinese medicine, Guangzhou 510405, China, ; 2.; 3.School of Chemistry and Chemical Engineering, Sun Yat-san University, Guangzhou 510275, China, |
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Abstract The uniform-sized spherical molecularly imprinted polymers were successfully prepared through molecular imprinting technology by two-step seed swelling and mini-emulsion polymerization in the aqueous condition using quinine as template molecules and methacrylic acid (MAA) as functional monomer. The polymers were characterized by IR spectra, thermal-weight analysis, scanning electron microscope and laser particle size analysis. The properties of imprinted polymers were investigated in different organic phases and aqueous media. In the organic media, results suggested that polar interactions (hydrogen bonding, ionic interactions) between acidic monomer/polymer and template molecules are mainly responsible for the binding and recognition; whereas in the aqueous medium, a considerable recognition effect was also obtained where the ionic (electrostatic) interaction and hydrophobic interaction play an important role. The experiments of binding different substrates indicated that the MIPs possessed an excellent rebinding ability and inherent selectivity to quinine.
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Issue Date: 05 June 2006
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