|
|
|
Inhibitory effects of curcumin derivatives on nonenzymatic glucosylation in vitro |
| Li Manmei1, Liu Zhong2, Zhang Zhulin2, Ma Lin3 |
| 1.Institute of Traditional Chinese Medicine and Natural Products Jinan University, Guangzhou 510632, China; 2.School of Pharmaceutical Science, Sun Yat-Sen University, Guangzhou 510080, China; 3.School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China |
|
|
|
|
Abstract In this paper, curcumin, demethoxycurcumin, bisdemethoxycurcumin and another curcumin derivative are investigated for their inhibitory effects on nonenzymatic glucosylation in vitro, their binding reaction with bovine serum albumin (BSA) and their influence on the conformational changes of BSA. It demonstrated that all of these curcumin derivatives inhibited the formation of advanced glycation end products (AGE). Curcumin showed the most potent inhibitory activity, followed by demethoxycurcumin and bisdemethoxycurcumin. Moreover, it indicated that they extensively binded to the protein and induced the conformational changes of BSA.
|
|
Issue Date: 05 June 2006
|
|
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
| |
Shared |
|
|
|
|
| |
Discussed |
|
|
|
|
