Synthesis of O-benzyl oximes by combination of phase transfer catalysis and ultrasound irradiation

doi:10.1007/s11458-009-0002-2

Front Chem Chin

2009, Vol. 4

Issue (1) : 58-62 https://doi.org/10.1007/s11458-009-0002-2

RESEARCH ARTICLE

Synthesis of O-benzyl oximes by combination of phase transfer catalysis and ultrasound irradiation

Jitai LI(

), Xiaoliang LI, Xianfeng LIU, Jiejie MA

Key Laboratory of Analytical Science and Technology of Hebei Province,College of Chemistry and Environmental Science,Hebei University,Baoding 071002,China

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Abstract

The reactions of oximes with benzyl bromide catalyzed by benzyldimethyltetradecylammonium chloride are carried out at room temperature for 30-60 min in aqueous sodium hydroxide solution under ultrasound irradiation to offer O-benzyl oxime derivatives in 60-96% yields. In comparison to classical methods, the advantages of the present procedure include short reaction time, high yields and environmental friendliness.

Keywords oxime ether phase transfer catalysis ultrasound etherification

Corresponding Author(s): LI Jitai,Email:lijitai@hbu.cn

Issue Date: 05 March 2009

Cite this article:

Jitai LI,Xianfeng LIU,Jiejie MA, et al. Synthesis of O-benzyl oximes by combination of phase transfer catalysis and ultrasound irradiation[J]. Front Chem Chin, 2009, 4(1): 58-62.

URL:

https://academic.hep.com.cn/fcc/EN/10.1007/s11458-009-0002-2
https://academic.hep.com.cn/fcc/EN/Y2009/V4/I1/58

Fig.1 Synthesis of O-benzyl oximes

Tab.1 The effect of reaction conditions on the etherification of 2-methoxybenzaldoxime with benzyl bromide under ultrasound action

Tab.2 The reaction of oximes with benzyl bromide in aqueous media catalyzed by benzyldimethyltetradecylammoniumchloride in combination with ultrasound irradiation

Fig.2 synthesis of O-benzyl oximes

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