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Frontiers of Computer Science

ISSN 2095-2228

ISSN 2095-2236(Online)

CN 10-1014/TP

Postal Subscription Code 80-970

2018 Impact Factor: 1.129

Front Comput Sci Chin    0, Vol. Issue () : 316-326    https://doi.org/10.1007/s11704-011-0116-9
Toward in vivo nanoscale communication networks: utilizing an active network architecture
Stephen F. BUSH()
GE Global Research, One Research Circle, Niskayuna, N Y 12309, USA
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Abstract

A safe and reliable in vivo nanoscale communication network will be of great benefit for medical diagnosis and monitoring as well as medical implant communication. This review article provides a brief introduction to nanoscale and molecular networking in general and provides opinions on the role of active networking for in vivo nanoscale information transport. While there are many in vivo communication mechanisms that can be leveraged, for example, forms of cell signaling, gap junctions, calcium and ion signaling, and circulatory borne communication, this review examines two in particular: molecular motor transport and neuronal information communication. Molecular motors transport molecules representing information and neural coding operates by means of the action potential; these mechanisms are reviewed within the theoretical framework of an active network. This review suggests that an active networking paradigm is necessary at the nanoscale along with a new communication constraint, namely, minimizing the communication impact upon the living environment. The goal is to assemble efficient nanoscale and molecular communication channels while minimizing disruption to the host organism.

Keywords nanoscale network      molecular communication      in vivo network      active network      molecular motor      neural coding     
Corresponding Author(s): BUSH Stephen F.,Email:bushsf@research.ge.com   
Issue Date: 05 September 2011
 Cite this article:   
Stephen F. BUSH. Toward in vivo nanoscale communication networks: utilizing an active network architecture[J]. Front Comput Sci Chin, 0, (): 316-326.
 URL:  
https://academic.hep.com.cn/fcs/EN/10.1007/s11704-011-0116-9
https://academic.hep.com.cn/fcs/EN/Y0/V/I/316
Fig.1  An illustration of the genesis of nanoscale and molecular communication networks. The arrows point toward the decreasing scales of biology, robotics, intrachip interconnects, and physics
Fig.2  Relative sizes of typical nanoscale and molecular communication components compared to the electromagnetic spectrum. (a) Decreasing sizes of nanoscale and molecular network components; (b) wavelength of electromagnetic radiation at the same scale as (a)
Fig.3  Active network architecture is shown as an evolution from circuit and packet switching. The active network execution environment allows code within packets to dynamically modify the operation of the channel.
Fig.4  Active network information theory is illustrated as an evolution from classical information theory. indicates executable code within a packet.
Fig.5  An active network channel can optionally utilize the executable code in the input to create or modify the communication channel.
Fig.6  Molecular motors transport a microtubule, thus repositioning it in order to modify and extend the network. This is one example of a biological active network.
Fig.7  A molecular motor active network channel can optionally transport and manipulate its own microtubule network, , to assemble or modify the communication channel.
Fig.8  A neural active network channel can optionally utilize action potentials and molecular motors to assemble and modify the channel.
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