Multiphase surfactant-assisted reaction-separation system in a microchannel reactor

doi:10.1007/s11705-009-0108-6

Front Chem Eng Chin

2009, Vol. 3

Issue (1) : 33-38 https://doi.org/10.1007/s11705-009-0108-6

RESEARCH ARTICLE

Multiphase surfactant-assisted reaction-separation system in a microchannel reactor

Salah ALJBOUR¹(

), Tomohiko TAGAWA¹, Mohammad MATOUQ², Hiroshi YAMADA¹

1. Department of Chemical Engineering, Nagoya University, Chikusa, Nagoya 464-8603, Japan; 2. Faculty of Engineering Technology, Al-Balqa Applied University, Amman 11134, Jordan

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Abstract

The Lewis acid-catalyzed addition of trimethylsilyl cyanide to p-chlorobenzaldehyde in a microchannel reactor was investigated. The microchannel was integrated to promote both reaction and separation of the biphase system. FeF₃ and Cu(triflate)₂ were used as water-stable Lewis acid catalysts. Sodium dodecyl sulfate was incorporated in the organic-aqueous system to enhance the reactivity and to manipulate the multiphase flow inside the microchannel. It was found that the dynamics and the kinetics of the multiphase reaction were affected by the new micellar system. Parallel multiphase flow inside the microchannel was obtained, allowing for continuous and acceptable phase separation. Enhanced selectivity was achieved by operating at lower conversion values.

Keywords Lewis acid catalysis multiphase reactions process intensification microchannel reactor green engineering

Corresponding Author(s): ALJBOUR Salah,Email:saljbour@yahoo.com

Issue Date: 05 March 2009

Cite this article:

Tomohiko TAGAWA,Mohammad MATOUQ,Hiroshi YAMADA, et al. Multiphase surfactant-assisted reaction-separation system in a microchannel reactor[J]. Front Chem Eng Chin, 2009, 3(1): 33-38.

URL:

https://academic.hep.com.cn/fcse/EN/10.1007/s11705-009-0108-6
https://academic.hep.com.cn/fcse/EN/Y2009/V3/I1/33

Fig.1 Addition of TMSCN to -chlorobenzaldehyde to afford the corresponding cyanohydrin/-chloromandelonitrile using water-stable Lewis acid catalysts

Fig.2 Microchannel reactor apparatus

Tab.1 HPLC analysis conditions

Fig.3 Slug flow at the inlet of the microchannel: organic phase (0.02 mol·L PCBA, 0.04 mol·L TMSCN, toluene), aqueous phase (0.006 mol·L FeF, water), ==0.001 mL?min

Fig.4 Slug flow inside the microchannel: organic phase (0.02 mol·L PCBA, 0.04 mol·L TMSCN, ethylacetate), aqueous phase (0.006 mol·L FeF, water), ==0.001 mL?min

Fig.5 Parallel flow at the inlet of the microchannel: organic phase (0.02 mol·L PCBA, 0.04 mol·L TMSCN, ethylacetate), aqueous phase (0.006 mol·L FeF, 0.028 mol·L SDS, water), ==0.001 mL?min

Fig.6 Parallel flow inside the microchannel: organic phase (0.02 mol·L PCBA, 0.04 mol·L TMSCN, ethylacetate), aqueous phase (0.006 mol·L FeF, 0.028 mol·L SDS, water), ==0.001 mL?min

Fig.7 Phase separation performance as a function of phase flow rate

Fig.8 Phase separation performance (==0.001 mL?min)

Fig.9 Effect of the amount of SDS on the conversion of PCBA: organic phase (0.02 mol·L PCBA, 0.04 mol·L TMSCN, ethyl acetate); aqueous phase (0.006 mol·L FeF, SDS, water); ==0.001 mL?min

Fig.10 Effect of the amount of SDS on the conversion of PCBA: organic phase (0.02 mol·L PCBA, 0.04 mol·L TMSCN, ethyl acetate); aqueous phase (0.002mol·L Cu (triflate), SDS, water); ==0.001 mL?min

Fig.11 Generation of HCN : organic phase (0.02 mol?L PCBA, 0.04 mol?L TMSCN, ethyl acetate); aqueous phase (0.006 mol?L FeF, 0.042 mol?L SDS, water); ==0.001 mL?min

Fig.12 Effect of residence time on the conversion of PCBA and selectivity: organic phase (0.02 mol?L PCBA, 0.04 mol?L TMSCN, ethyl acetate); aqueous phase (0.006 mol?L FeF, 0.028 mol?L SDS, water)

Fig.13 Effect of residence time on the conversion of PCBA and selectivity: organic phase (0.02 mol?L PCBA, 0.04 mol?L TMSCN, ethyl acetate); aqueous phase (0.002 mol?L Cu (triflate), 0.017 mol?L SDS, water)

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