Glyco-functionalised quantum dots and their progress in cancer diagnosis and treatment

doi:10.1007/s11705-019-1863-7

Front. Chem. Sci. Eng.

2020, Vol. 14

Issue (3) : 365-377 https://doi.org/10.1007/s11705-019-1863-7

REVIEW ARTICLE

Glyco-functionalised quantum dots and their progress in cancer diagnosis and treatment

Jayshree Ashree¹, Qi Wang², Yimin Chao¹(

)

¹. School of Chemistry, University of East Anglia, Norwich, NR4 7TJ, UK
². Norwich Medical School, University of East Anglia, Norwich, NR4 7TJ, UK

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Abstract

Despite all major breakthroughs in recent years of research, we are still unsuccessful to effectively diagnose and treat cancer that has express and metastasizes. Thus, the development of a novel approach for cancer detection and treatment is crucial. Recent progress in Glyconanotechnology has allowed the use of glycans and lectins as bio-functional molecules for many biological and biomedical applications. With the known advantages of quantum dots (QDs) and versatility of carbohydrates and lectins, Glyco-functionalised QD is a new prospect in constructing biomedical imaging platform for cancer behaviour study as well as treatment. In this review, we aim to describe the current utilisation of Glyco-functionalised QDs as well as their future prospective to interpret and confront cancer.

Keywords carbohydrate leptin glyco-functionalised QD bioimaging cancer diagnosis and treatment

Corresponding Author(s): Yimin Chao

Just Accepted Date: 26 July 2019 Online First Date: 29 September 2019 Issue Date: 28 April 2020

Cite this article:

Jayshree Ashree,Qi Wang,Yimin Chao. Glyco-functionalised quantum dots and their progress in cancer diagnosis and treatment[J]. Front. Chem. Sci. Eng., 2020, 14(3): 365-377.

URL:

https://academic.hep.com.cn/fcse/EN/10.1007/s11705-019-1863-7
https://academic.hep.com.cn/fcse/EN/Y2020/V14/I3/365

Fig.1 Scheme of the cell membrane carbohydrate residues labelling with lectin-QDs.

Tab.1 Summary of lectin-functionalised QD conjugates for cancer diagnosis reported in literature

Fig.2 (A) Schematic representation of lectin–QDs conjugates: QD550-DSA and QD618-LCA detecting cell surface carbohydrates. (B) Fluorescence microscopy images of HepG2 cells stained by functionalised QDs. (Adapted with permission from Ref. [⁵⁰], published by The Royal Society of Chemistry)

Tab.2 Summary of carbohydrate-functionalised QDs targeting various types of cancer reported in literature

Fig.3 Live animal imaging module of mice treated with glyco-functionalised QDs carrying Lewis antigen-related oligosaccharides. (Reproduced with permission from Ref. [⁵⁵], Copyright American Chemical Society)

Fig.4 Confocal fluorescent images showing the uptake of Gg3-dye@SiNPs by B16F10 cells after 2 h incubation. SiNPs inherent fluorescence-blue, DIC-differential interference contrast microscopy, early endosomes-green (stained with an anti-EEA1 antibody), actin cytoskeleton-red (stained with Alexa 555-labeled phalloidin). (Adapted with permission from Ref. [⁶⁰], Copyright American Chemical Society)

Fig.5 (A) In vivo toxicity assay using X. laevis embryos. Embryos exposed to carbohydrate capped SiNPs at a concentration of 200 mg?mL⁻¹: (a) control, (b) gal capped SiNPs, (c) man capped SiNPs, (d) Glu capped SiNPs, (e) Lac capped SiNPs, and (f) amine-terminated SiNPs. Embryos were exposed to the SiNPs at NF stage 15 and scored at NF stage 38; (B) Time dependent uptake efficiency of carbohydrate capped SiNPs in SK-Mel28 cells at various incubation times; (C) Uptake efficiency of carbohydrate capped SiNPs in cancer cells (A549, SK-Mel28, and MCF-7) and noncancerous cells (MDCK, HHL5) at 24 h. (Copyright Wiley, adapted with permission from Ref. [⁶⁴])

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