2019 highlights of the structural revision of natural product <i>via</i> total synthesis

doi:10.1007/s11705-020-1971-4

Front. Chem. Sci. Eng.

2021, Vol. 15

Issue (3) : 595-601 https://doi.org/10.1007/s11705-020-1971-4

VIEWS & COMMENTS

2019 highlights of the structural revision of natural product via total synthesis

Zongjia Chen, Mark A. Rizzacasa(

)

School of Chemistry, The Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC 3010, Australia

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Corresponding Author(s): Mark A. Rizzacasa

Just Accepted Date: 08 September 2020 Online First Date: 13 November 2020 Issue Date: 10 May 2021

Cite this article:

Zongjia Chen,Mark A. Rizzacasa. 2019 highlights of the structural revision of natural product via total synthesis[J]. Front. Chem. Sci. Eng., 2021, 15(3): 595-601.

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https://academic.hep.com.cn/fcse/EN/10.1007/s11705-020-1971-4
https://academic.hep.com.cn/fcse/EN/Y2021/V15/I3/595

Fig.1 Scheme 1 Onogashira coupling and revised structure of monocillin VII (4a) [15].

Fig.2 Scheme 2 Synthesis of pyrimidinedione 2d and revised structure of biemamides B (9a) and B (9b) [17].

Fig.3 Scheme 3 Cascade rearrangement and revised structure of citrafungin A (13a) [23].

Fig.4 Scheme 4 Cycloisomerization and revised structure of harziane diterpenoid (19a) [25].

Fig.5 Scheme 5 Redox reaction and revised structure of (+)-marineosin A (23a) [33].

Fig.6 Scheme 6 Indole macrocyclization and revised structure of streptide (26) [35].

Fig.7 Scheme 7 Julia olefination and revised structure of mytilipin B (31) [38].

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