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A boronic acid-based fluorescent hydrogel for monosaccharide detection |
Suying Xu1,2, Adam C. Sedgwick2,3, Souad A. Elfeky2,4,5,6, Wenbo Chen2,4,7, Ashley S. Jones2, George T. Williams2, A. Toby A. Jenkins2, Steven D. Bull2, John S. Fossey4(), Tony D. James2() |
1. Department of Biochemistry, Faculty of Science, Beijing University of Chemical Technology, Beijing 100029, China 2. Department of Chemistry, University of Bath, Bath BA2 7AY, UK 3. Department of Chemistry, University of Texas at Austin, TX 78712-1224, USA 4. School of Chemistry, University of Birmingham, Birmingham B15 2TT, UK 5. National Institute of Laser Enhanced Sciences, Cairo University, Giza 12613, Egypt 6. Higher Institute for Optics Technology, Sheraton, Cairo 17361, Egypt 7. Shanghai Key Laboratory of Materials Protection and Advanced Materials in Electric Power, Shanghai University of Electric Power, Shanghai 200090, China |
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Abstract A boronic acid-based anthracene fluorescent probe was functionalised with an acrylamide unit to incorporate into a hydrogel system for monosaccharide detection. In solution, the fluorescent probe displayed a strong fluorescence turn-on response upon exposure to fructose, and an expected trend in apparent binding constants, as judged by a fluorescence response where D-fructose>D-galactose>D-mannose>D-glucose. The hydrogel incorporating the boronic acid monomer demonstrated the ability to detect monosaccharides by fluorescence with the same overall trend as the monomer in solution with the addition of D-fructose resulting in a 10-fold enhancement (≤0.25 mol/L).
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Corresponding Author(s):
John S. Fossey,Tony D. James
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Just Accepted Date: 20 March 2019
Online First Date: 16 May 2019
Issue Date: 20 January 2020
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