During the Nationalist Era, China dealt with its relatively weaker position in the global geopolitics of news communication by forging and managing strategic collaborations with the world’s leading news agencies. This study analyzes the case of the bilateral contractual relationship between Reuters and the Guomindang (GMD) government’s official news agency, the Central News Agency (CNA). By doing so, the article reveals that in the course of developing useful cooperation with the leading international news agencies to open up inter-institutional and interpersonal channels and networks for disseminating the GMD government’s official news and viewpoints abroad, the GMD government and CNA were also confronted with a growing necessity to manage and control protracted contentions, disputes, and even conflicts arising from the party-state’s persistent attempts to assert news communication sovereignty. The study also highlights the vital role of Zhao Minheng (1904–61)—a US-educated Chinese journalist in the employment of Reuters—as middleman in the CNA-Reuters relationship. Zhao’s career provides us with an important means to analyze CNA’s international news-agency relations from transnational and transcultural perspectives.