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Frontiers in Biology

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ISSN 1674-7992(Online)

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Front Biol    2011, Vol. 6 Issue (4) : 328-336    https://doi.org/10.1007/s11515-011-1070-5
REVIEW
The mechanism of protein kinase C regulation
Julhash U. KAZI1,2()
1. Laboratory of Computational Biochemistry, KN Biomedical Research Institute, Bagura Road, Barisal, Bangladesh;; 2. Quality Control Section, Opsonin Pharma Ltd, Bagura Road, Barisal, Bangladesh
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Abstract

Protein kinase C (PKC) is a family of serine/threonine protein kinases that plays a central role in transducing extracellular signals into a variety of intracellular responses ranging from cell proliferation to apoptosis. Nine PKC genes have been identified in the human genome, which encode 10 proteins. Each member of this protein kinase family displays distinct biochemical characteristics and is enriched in different cellular and subcellular locations. Activation of PKC has been implicated in the regulation of cell growth and differentiation. This review summarizes works of the past years in the field of PKC biochemistry that covers regulation and activation mechanism of different PKC isoforms.
Keywords PKC      biochemistry      PKC kinase      PKC phosphatases      PKC structure     
Corresponding Author(s): KAZI Julhash U.,Email:lcb.kazi@gmail.com   
Issue Date: 01 August 2011
 Cite this article:   
Julhash U. KAZI. The mechanism of protein kinase C regulation[J]. Front Biol, 2011, 6(4): 328-336.
 URL:  
https://academic.hep.com.cn/fib/EN/10.1007/s11515-011-1070-5
https://academic.hep.com.cn/fib/EN/Y2011/V6/I4/328
Fig.1  Schematic representation of the structure of the PKC family.
Fig.2  Three dimensional structures of PKC-C2 domains.
Fig.3  PKC activation mechanism.
GroupFamilyKinasePKCReference
AGCPKBPDK1PKCα, PKCβ2, PKCδ, PKC?, PKCθ, PKCζChou et al., 1998; Dutil et al., 1998; Le Good et al., 1998; Cenni et al., 2002; Lee et al., 2005
AGCPKCPKCδPKC?Rybin et al., 2003
AGCPKCPKC?PKCδRybin et al., 2003
AGCPKCPKCζPKCδZiegler et al., 1999
OtherCK1CK1Rat brain PKCVila et al., 1989
OtherCK2CK2PKCβTominaga et al., 1991
TKAblcAblPKCδSun et al., 2000
TKSrcFynPKCδDenning et al., 1996
TKSrcLckPKCδ, PKCθLiu et al., 2000; Konishi et al., 2001
TKSrcLynPKCδSzallasi et al., 1995
TKSrcSrcPKCδ, PKCiDenning et al., 1996; Wooten et al., 2001
TKSykSykPKCα, PKCβ1Kawakami et al., 2003
Tab.1  Isoform-specific PKC kinases
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