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Progress in Brucella vaccine development |
Xinghong YANG( ), Jerod A. SKYBERG, Ling CAO, Beata CLAPP, Theresa THORNBURG, David W. PASCUAL |
| Department of Immunology & Infectious Diseases, Montana State University, Bozeman, MT 59717-3610, USA |
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Abstract Brucella spp. are zoonotic, facultative intracellular pathogens, which cause animal and human disease. Animal disease results in abortion of fetuses; in humans, it manifests flu-like symptoms with an undulant fever, with osteoarthritis as a common complication of infection. Antibiotic regimens for human brucellosis patients may last several months and are not always completely effective. While there are no vaccines for humans, several licensed live Brucella vaccines are available for use in livestock. The performance of these animal vaccines is dependent upon the host species, dose, and route of immunization. Newly engineered live vaccines, lacking well-defined virulence factors, retain low residual virulence, are highly protective, and may someday replace currently used animal vaccines. These also have possible human applications. Moreover, due to their enhanced safety and efficacy in animal models, subunit vaccines for brucellosis show great promise for their application in livestock and humans. This review summarizes the progress of brucellosis vaccine development and presents an overview of candidate vaccines.
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| Keywords
Brucella
brucellosis
zoonosis
livestock vaccines
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Corresponding Author(s):
YANG Xinghong,Email:yangxh@montana.edu
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Issue Date: 01 February 2013
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| 1 |
Abu Shaqra Q M (2000). Epidemiological aspects of brucellosis in Jordan. Eur J Epidemiol , 16(6): 581-584
doi: 10.1023/A:1007688925027 pmid:11049102
|
| 2 |
Adone R, Ciuchini F, Marianelli C, Tarantino M, Pistoia C, Marcon G, Petrucci P, Francia M, Riccardi G, Pasquali P (2005). Protective properties of rifampin-resistant rough mutants of Brucella melitensis. Infect Immun , 73(7): 4198-4204
doi: 10.1128/IAI.73.7.4198-4204.2005 pmid:15972510
|
| 3 |
Al-Mariri A, Tibor A, Mertens P, De Bolle X, Michel P, Godefroid J, Walravens K, Letesson J J (2001). Protection of BALB/c mice against Brucella abortus 544 challenge by vaccination with bacterioferritin or P39 recombinant proteins with CpG oligodeoxynucleotides as adjuvant. Infect Immun , 69(8): 4816-4822
doi: 10.1128/IAI.69.8.4816-4822.2001 pmid:11447155
|
| 4 |
Alcantara R B, Read R D, Valderas M W, Brown T D, Roop R M 2nd (2004). Intact purine biosynthesis pathways are required for wild-type virulence of Brucella abortus 2308 in the BALB/c mouse model. Infect Immun , 72(8): 4911-4917
doi: 10.1128/IAI.72.8.4911-4917.2004 pmid:15271960
|
| 5 |
Almirón M, Martínez M, Sanjuan N, Ugalde R A (2001). Ferrochelatase is present in Brucella abortus and is critical for its intracellular survival and virulence. Infect Immun , 69(10): 6225-6230
doi: 10.1128/IAI.69.10.6225-6230.2001 pmid:11553564
|
| 6 |
Alton G G (1966). Duration of the immunity produced in goats by the Rev. 1 Brucella melitensis vaccine. J Comp Pathol , 76(3): 241-253
doi: 10.1016/0021-9975(66)90003-X pmid:6007463
|
| 7 |
Alton G G (1968). Further studies on the duration of the immunity produced in goats by the Rev. 1 Brucella melitensis vaccine. J Comp Pathol , 78(2): 173-178
doi: 10.1016/0021-9975(68)90093-5 pmid:5648807
|
| 8 |
Arellano-Reynoso B, Lapaque N, Salcedo S, Briones G, Ciocchini A E, Ugalde R, Moreno E, Moriyón I, Gorvel J P (2005). Cyclic β-1,2-glucan is a Brucella virulence factor required for intracellular survival. Nat Immunol , 6(6): 618-625
doi: 10.1038/ni1202 pmid:15880113
|
| 9 |
Arenas-Gamboa A M, Ficht T A, Davis D S, Elzer P H, Kahl-McDonagh M, Wong-Gonzalez A, Rice-Ficht A C (2009a). Oral vaccination with microencapsuled strain 19 vaccine confers enhanced protection against Brucella abortus strain 2308 challenge in red deer (Cervus elaphus elaphus). J Wildl Dis , 45(4): 1021-1029
pmid:19901378
|
| 10 |
Arenas-Gamboa A M, Ficht T A, Davis D S, Elzer P H, Wong-Gonzalez A, Rice-Ficht A C (2009b). Enhanced immune response of red deer (Cervus elaphus) to live rb51 vaccine strain using composite microspheres. J Wildl Dis , 45(1): 165-173
pmid:19204345
|
| 11 |
Arenas-Gamboa A M, Ficht T A, Kahl-McDonagh M M, Gomez G, Rice-Ficht A C (2009c). The Brucella abortus S19 DeltavjbR live vaccine candidate is safer than S19 and confers protection against wild-type challenge in BALB/c mice when delivered in a sustained-release vehicle. Infect Immun , 77(2): 877-884
doi: 10.1128/IAI.01017-08 pmid:19047401
|
| 12 |
Arenas-Gamboa A M, Ficht T A, Kahl-McDonagh M M, Rice-Ficht A C (2008). Immunization with a single dose of a microencapsulated Brucella melitensis mutant enhances protection against wild-type challenge. Infect Immun , 76(6): 2448-2455
doi: 10.1128/IAI.00767-07 pmid:18362129
|
| 13 |
Arenas-Gamboa A M, Rice-Ficht A C, Kahl-McDonagh M M, Ficht T A (2011). Protective efficacy and safety of Brucella melitensis 16MΔmucR against intraperitoneal and aerosol challenge in BALB/c mice. Infect Immun , 79(9): 3653-3658
doi: 10.1128/IAI.05330-11 pmid:21708998
|
| 14 |
Ascón M A, Ochoa-Repáraz J, Walters N, Pascual D W (2005). Partially assembled K99 fimbriae are required for protection. Infect Immun , 73(11): 7274-7280
doi: 10.1128/IAI.73.11.7274-7280.2005 pmid:16239523
|
| 15 |
Ashford D A, di Pietra J, Lingappa J, Woods C, Noll H, Neville B, Weyant R, Bragg S L, Spiegel R A, Tappero J, Perkins B A (2004). Adverse events in humans associated with accidental exposure to the livestock brucellosis vaccine RB51. Vaccine , 22(25-26): 3435-3439
doi: 10.1016/j.vaccine.2004.02.041 pmid:15308369
|
| 16 |
Atluri V L, Xavier M N, de Jong M F, den Hartigh A B, Tsolis R E (2011). Interactions of the human pathogenic Brucella species with their hosts. Annu Rev Microbiol , 65(1): 523-541
doi: 10.1146/annurev-micro-090110-102905 pmid:21939378
|
| 17 |
Audic S, Lescot M, Claverie J M, Scholz H C (2009). Brucella microti: the genome sequence of an emerging pathogen. BMC Genomics , 10(1): 352
doi: 10.1186/1471-2164-10-352 pmid:19653890
|
| 18 |
B?ckhed F, Normark S, Schweda E K, Oscarson S, Richter-Dahlfors A (2003). Structural requirements for TLR4-mediated LPS signalling: a biological role for LPS modifications. Microbes Infect , 5(12): 1057-1063
doi: 10.1016/S1286-4579(03)00207-7 pmid:14554246
|
| 19 |
Baldi, P.C., Wallach, J.C., Ferrero, M.C., Delpino, M.V., and Fossati, C.A. (2008). Occupational infection due to Brucella abortus S19 among workers involved in vaccine production in Argentina. CMI , 14: 805-80 7
|
| 20 |
Baloglu S, Boyle S M, Vemulapalli R, Sriranganathan N, Schurig G G, Toth T E (2005). Immune responses of mice to vaccinia virus recombinants expressing either Listeria monocytogenes partial listeriolysin or Brucella abortus ribosomal L7/L12 protein. Vet Microbiol , 109(1-2): 11-17
doi: 10.1016/j.vetmic.2005.04.011 pmid:15941627
|
| 21 |
Banai M (2002). Control of small ruminant brucellosis by use of Brucella melitensis Rev.1 vaccine: laboratory aspects and field observations. Vet Microbiol , 90(1-4): 497-519
doi: 10.1016/S0378-1135(02)00231-6 pmid:12414167
|
| 22 |
Bandara A B, Poff-Reichow S A, Nikolich M, Hoover D L, Sriranganathan N, Schurig G G, Dobrean V, Boyle S M (2009). Simultaneous expression of homologous and heterologous antigens in rough, attenuated Brucella melitensis. Microbes Infect , 11(3): 424-428
doi: 10.1016/j.micinf.2009.01.003 pmid:19397881
|
| 23 |
Barquero-Calvo E, Chaves-Olarte E, Weiss D S, Guzmán-Verri C, Chacón-Díaz C, Rucavado A, Moriyón I, Moreno E (2007). Brucella abortus uses a stealthy strategy to avoid activation of the innate immune system during the onset of infection. PLoS ONE , 2(7): e631
doi: 10.1371/journal.pone.0000631 pmid:17637846
|
| 24 |
Barrio M B, Grilló M J, Mu?oz P M, Jacques I, González D, de Miguel M J, Marín C M, Barberán M, Letesson J J, Gorvel J P, Moriyón I, Blasco J M, Zygmunt M S (2009). Rough mutants defective in core and O-polysaccharide synthesis and export induce antibodies reacting in an indirect ELISA with smooth lipopolysaccharide and are less effective than Rev 1 vaccine against Brucella melitensis infection of sheep. Vaccine , 27(11): 1741-1749
doi: 10.1016/j.vaccine.2009.01.025 pmid:19186196
|
| 25 |
Barrionuevo P, Delpino M V, Velásquez L N, García Samartino C, Coria L M, Iba?ez A E, Rodríguez M E, Cassataro J, Giambartolomei G H (2011). Brucella abortus inhibits IFN-γ-induced FcγRI expression and FcγRI-restricted phagocytosis via toll-like receptor 2 on human monocytes/macrophages. Microbes Infect , 13(3): 239-250
doi: 10.1016/j.micinf.2010.10.020 pmid:21070860
|
| 26 |
Beckett F W, MacDiarmid S C (1985). The effect of reduced-dose Brucella abortus strain 19 vaccination in accredited dairy herds. Br Vet J , 141(5): 507-514
pmid:4063777
|
| 27 |
Bercovich Z (2000). The use of skin delayed-type hypersensitivity as an adjunct test to diagnose brucellosis in cattle: a review. Vet Q , 22(3): 123-130
doi: 10.1080/01652176.2000.9695040 pmid:10952440
|
| 28 |
Bhattacharjee A K, Izadjoo M J, Zollinger W D, Nikolich M P, Hoover D L (2006). Comparison of protective efficacy of subcutaneous versus intranasal immunization of mice with a Brucella melitensis lipopolysaccharide subunit vaccine. Infect Immun , 74(10): 5820-5825
doi: 10.1128/IAI.00331-06 pmid:16988260
|
| 29 |
Blasco J M, Díaz R (1993). Brucella melitensis Rev-1 vaccine as a cause of human brucellosis. Lancet , 342(8874): 805
doi: 10.1016/0140-6736(93)91571-3 pmid:8103891
|
| 30 |
Blasco J M, Marín C, Jiménez de Bagüés M P, Barberán M (1993). Efficacy of Brucella suis strain 2 vaccine against Brucella ovis in rams. Vaccine , 11(13): 1291-1294
doi: 10.1016/0264-410X(93)90097-H pmid:8296481
|
| 31 |
Borts I H, McNUTT S H, Jordan C F (1946). Brucella melitensis isolated from swine tissues in Iowa. J Am Med Assoc , 130(14): 966-966
doi: 10.1001/jama.1946.02870140058022 pmid:21019101
|
| 32 |
Boschiroli M L, Cravero S L, Arese A I, Campos E, Rossetti O L (1997). Protection against infection in mice vaccinated with a Brucella abortus mutant. Infect Immun , 65(2): 798-800
pmid:9009345
|
| 33 |
Bosseray N (1991). Brucella melitensis Rev. 1 living attenuated vaccine: stability of markers, residual virulence and immunogenicity in mice. Biologicals , 19(4): 355-363
doi: 10.1016/S1045-1056(05)80025-9 pmid:1797046
|
| 34 |
Bosseray N, Plommet M (1990). Brucella suis S2, brucella melitensis Rev. 1 and Brucella abortus S19 living vaccines: residual virulence and immunity induced against three Brucella species challenge strains in mice. Vaccine , 8(5): 462-468
doi: 10.1016/0264-410X(90)90247-J pmid:2123586
|
| 35 |
Briones G, I?ón de Iannino N, Roset M, Vigliocco A, Paulo P S, Ugalde R A (2001). Brucella abortus cyclic beta-1,2-glucan mutants have reduced virulence in mice and are defective in intracellular replication in HeLa cells. Infect Immun , 69(7): 4528-4535
doi: 10.1128/IAI.69.7.4528-4535.2001 pmid:11401996
|
| 36 |
Burkhardt S, Jiménez de Bagüés M P, Liautard J P, K?hler S (2005). Analysis of the behavior of eryC mutants of Brucella suis attenuated in macrophages. Infect Immun , 73(10): 6782-6790
doi: 10.1128/IAI.73.10.6782-6790.2005 pmid:16177356
|
| 37 |
Buyukcangaz E, Sen A (2007). The first isolation of Brucella melitensis from bovine aborted fetus in Turkey. J Biol Environ Sci , 1: 139-142
|
| 38 |
Cabrera A, Sáez D, Céspedes S, Andrews E, O?ate A (2009). Vaccination with recombinant Semliki Forest virus particles expressing translation initiation factor 3 of Brucella abortus induces protective immunity in BALB/c mice. Immunobiology , 214(6): 467-474
doi: 10.1016/j.imbio.2008.11.016 pmid:19150742
|
| 39 |
Caporale V, Bonfini B, Di Giannatale E, Di Provvido A, Forcella S, Giovannini A, Tittarelli M, Scacchia M (2010). Efficacy of Brucella abortus vaccine strain RB51 compared to the reference vaccine Brucella abortus strain 19 in water buffalo. Vet Ital , 46(1): 13-19, 5-11
pmid:20391363
|
| 40 |
Cardena A P, Herrera D M, Zamora J L F, Pina F B, Sanchez B M, Ruiz E J G, Williams J J, Alvarez F M, Castro R F (2009). Evaluation of vaccination with Brucella abortus S19 vaccine in cattle naturally infected with brucellosis in productive systems found in the Mexican Tropic. Int J Dairy Sci , 4(4): 142-151
doi: 10.3923/ijds.2009.142.151
|
| 41 |
Cassataro J, Estein S M, Pasquevich K A, Velikovsky C A, de la Barrera S, Bowden R, Fossati C A, Giambartolomei G H (2005). Vaccination with the recombinant Brucella outer membrane protein 31 or a derived 27-amino-acid synthetic peptide elicits a CD4+ T helper 1 response that protects against Brucella melitensis infection. Infect Immun , 73(12): 8079-8088
doi: 10.1128/IAI.73.12.8079-8088.2005 pmid:16299302
|
| 42 |
Casta?o M J, Solera J (2009). Chronic brucellosis and persistence of Brucella melitensis DNA. J Clin Microbiol , 47(7): 2084-2089
doi: 10.1128/JCM.02159-08 pmid:19420176
|
| 43 |
Centers for Disease Control and Prevention (CDC) (1998). Human exposure to Brucella abortus strain RB51—Kansas, 1997. MMWR Morb Mortal Wkly Rep , 47(9): 172-175
pmid:9518281
|
| 44 |
Cespedes S, Andrews E, Folch H, O?ate A (2000). Identification and partial characterisation of a new protective antigen of Brucella abortus. J Med Microbiol , 49(2): 165-170
pmid:10670567
|
| 45 |
Chacón-Díaz C, Mu?oz-Rodríguez M, Barquero-Calvo E, Guzmán-Verri C, Chaves-Olarte E, Grilló M J, Moreno E (2011). The use of green fluorescent protein as a marker for Brucella vaccines. Vaccine , 29(3): 577-582
doi: 10.1016/j.vaccine.2010.09.109 pmid:21056079
|
| 46 |
Chain P S, Comerci D J, Tolmasky M E, Larimer F W, Malfatti S A, Vergez L M, Aguero F, Land M L, Ugalde R A, Garcia E (2005). Whole-genome analyses of speciation events in pathogenic Brucellae. Infect Immun , 73(12): 8353-8361
doi: 10.1128/IAI.73.12.8353-8361.2005 pmid:16299333
|
| 47 |
Cheville N F, McCullough D R, Paulson L R (1998). Brucellosis in the greater Yellowstone area, Vol National Research Council (U.S.). Board on Agriculture. National Research Council (U.S.). Board on Environmental Studies and Toxicology , Washington, D.C., National Academy Press
|
| 48 |
Cheville N F, Olsen S C, Jensen A E, Stevens M G, Florance A M, Houng H S, Drazek E S, Warren R L, Hadfield T L, Hoover D L (1996a). Bacterial persistence and immunity in goats vaccinated with a purE deletion mutant or the parental 16M strain of Brucella melitensis. Infect Immun , 64(7): 2431-2439
pmid:8698463
|
| 49 |
Cheville N F, Olsen S C, Jensen A E, Stevens M G, Palmer M V, Florance A M (1996b). Effects of age at vaccination on efficacy of Brucella abortus strain RB51 to protect cattle against brucellosis. Am J Vet Res , 57(8): 1153-1156
pmid:8836366
|
| 50 |
Cheville N F, Stevens M G, Jensen A E, Tatum F M, Halling S M (1993). Immune responses and protection against infection and abortion in cattle experimentally vaccinated with mutant strains of Brucella abortus. Am J Vet Res , 54(10): 1591-1597
pmid:8250382
|
| 51 |
Clapp B, Skyberg J A, Yang X, Thornburg T, Walters N, Pascual D W (2011a). Protective live oral brucellosis vaccines stimulate Th1 and th17 cell responses. Infect Immun , 79(10): 4165-4174
doi: 10.1128/IAI.05080-11 pmid:21768283
|
| 52 |
Clapp B, Walters N, Thornburg T, Hoyt T, Yang X, Pascual D W (2011b). DNA vaccination of bison to brucellar antigens elicits elevated antibody and IFN-γ responses. J Wildl Dis , 47(3): 501-510
pmid:21719815
|
| 53 |
Cloeckaert A, Debbarh H S, Vizcaíno N, Saman E, Dubray G, Zygmunt M S (1996). Cloning, nucleotide sequence, and expression of the Brucella melitensis bp26 gene coding for a protein immunogenic in infected sheep. FEMS Microbiol Lett , 140(2-3): 139-144
doi: 10.1111/j.1574-6968.1996.tb08327.x pmid:8764475
|
| 54 |
Commander N J, Spencer S A, Wren B W, MacMillan A P (2007). The identification of two protective DNA vaccines from a panel of five plasmid constructs encoding Brucella melitensis 16M genes. Vaccine , 25(1): 43-54
doi: 10.1016/j.vaccine.2006.07.046 pmid:17049676
|
| 55 |
Conde-Alvarez R, Grilló M J, Salcedo S P, de Miguel M J, Fugier E, Gorvel J P, Moriyón I, Iriarte M (2006). Synthesis of phosphatidylcholine, a typical eukaryotic phospholipid, is necessary for full virulence of the intracellular bacterial parasite Brucella abortus. Cell Microbiol , 8(8): 1322-1335
doi: 10.1111/j.1462-5822.2006.00712.x pmid:16882035
|
| 56 |
Confer A W, Hall S M, Faulkner C B, Espe B H, Deyoe B L, Morton R J, Smith R A (1985). Effects of challenge dose on the clinical and immune responses of cattle vaccinated with reduced doses of Brucella abortus strain 19. Vet Microbiol , 10(6): 561-575
doi: 10.1016/0378-1135(85)90065-3 pmid:3938101
|
| 57 |
Contreras-Rodriguez A, Ramirez-Zavala B, Contreras A, Schurig G G, Sriranganathan N, Lopez-Merino A (2003). Purification and characterization of an immunogenic aminopeptidase of Brucella melitensis. Infect Immun , 71(9): 5238-5244
doi: 10.1128/IAI.71.9.5238-5244.2003 pmid:12933870
|
| 58 |
Cook, W.E., Williams, E.S., Thorne, E.T., Kreeger, T.J., Stout, G., Bardsley, K., Edwards, H., Schurig, G., Colby, L.A., Enright, F., et al. (2002). Brucella abortus strain RB51 vaccination in elk. I. Efficacy of reduced dosage. J Wildl Dis , 38: 18-26
|
| 59 |
Corbel M J (1997). Brucellosis: an overview. Emerg Infect Dis , 3(2): 213-221
doi: 10.3201/eid0302.970219 pmid:9204307
|
| 60 |
Crasta O R, Folkerts O, Fei Z, Mane S P, Evans C, Martino-Catt S, Bricker B, Yu G, Du L, Sobral B W (2008). Genome sequence of Brucella abortus vaccine strain S19 compared to virulent strains yields candidate virulence genes. PLoS ONE , 3(5): e2193
doi: 10.1371/journal.pone.0002193 pmid:18478107
|
| 61 |
Da Costa Martins R, Irache J M, Blasco J M, Mu?oz M P, Marín C M, Jesús Grilló M, Jesús De Miguel M, Barberán M, Gamazo C (2010). Evaluation of particulate acellular vaccines against Brucella ovis infection in rams. Vaccine , 28(17): 3038-3046
doi: 10.1016/j.vaccine.2009.10.073 pmid:19887131
|
| 62 |
Davis D S, Elzer P H (2002). Brucella vaccines in wildlife. Vet Microbiol , 90(1-4): 533-544
doi: 10.1016/S0378-1135(02)00233-X pmid:12414169
|
| 63 |
Davis D S, Templeton J W, Ficht T A, Huber J D, Angus R D, Adams L G (1991). Brucella abortus in Bison. II. Evaluation of strain 19 vaccination of pregnant cows. J Wildl Dis , 27(2): 258-264
pmid:1906114
|
| 64 |
Delpino M V, Estein S M, Fossati C A, Baldi P C, Cassataro J (2007). Vaccination with Brucella recombinant DnaK and SurA proteins induces protection against Brucella abortus infection in BALB/c mice. Vaccine , 25(37-38): 6721-6729
doi: 10.1016/j.vaccine.2007.07.002 pmid:17686554
|
| 65 |
den Hartigh A B, Sun Y H, Sondervan D, Heuvelmans N, Reinders M O, Ficht T A, Tsolis R M (2004). Differential requirements for VirB1 and VirB2 during Brucella abortus infection. Infect Immun , 72(9): 5143-5149
doi: 10.1128/IAI.72.9.5143-5149.2004 pmid:15322008
|
| 66 |
Diju I U (2009). Brucellosis—an under-estimated cause of arthralgia & muscular pains in general population. J Ayub Med Coll Abbottabad , 21(2): 128-131
pmid:20524489
|
| 67 |
Diptee M D, Adesiyun A A, Asgarali Z, Campbell M, Adone R (2006). Serologic responses, biosafety and clearance of four dosages of Brucella abortus strain RB51 in 6-10 months old water buffalo (Bubalus bubalis). Vet Immunol Immunopathol , 109(1-2): 43-55
doi: 10.1016/j.vetimm.2005.07.020 pmid:16112746
|
| 68 |
Dornand J, Lafont V, Oliaro J, Terraza A, Castaneda-Roldan E, Liautard J P (2004). Impairment of intramacrophagic Brucella suis multiplication by human natural killer cells through a contact-dependent mechanism. Infect Immun , 72(4): 2303-2311
doi: 10.1128/IAI.72.4.2303-2311.2004 pmid:15039355
|
| 69 |
Due?as A I, Ordu?a A, Crespo M S, García-Rodríguez C (2004). Interaction of endotoxins with Toll-like receptor 4 correlates with their endotoxic potential and may explain the proinflammatory effect of Brucella spp. LPS. Int Immunol , 16(10): 1467-1475
doi: 10.1093/intimm/dxh148 pmid:15339879
|
| 70 |
Dzata G K, Confer A W, Wyckoff J H 3rd (1991). The effects of adjuvants on immune responses in cattle injected with a Brucella abortus soluble antigen. Vet Microbiol , 29(1): 27-48
doi: 10.1016/0378-1135(91)90108-R pmid:1835213
|
| 71 |
Ebel E D, Williams M S, Tomlinson S M (2008). Estimating herd prevalence of bovine brucellosis in 46 USA states using slaughter surveillance. Prev Vet Med , 85(3-4): 295-316
doi: 10.1016/j.prevetmed.2008.02.005 pmid:18359525
|
| 72 |
Edmonds M D, Cloeckaert A, Elzer P H (2002a). Brucella species lacking the major outer membrane protein Omp25 are attenuated in mice and protect against Brucella melitensis and Brucella ovis. Vet Microbiol , 88(3): 205-221
doi: 10.1016/S0378-1135(02)00110-4 pmid:12151196
|
| 73 |
Edmonds M D, Cloeckaert A, Hagius S D, Samartino L E, Fulton W T, Walker J V, Enright F M, Booth N J, Elzer P H (2002b). Pathogenicity and protective activity in pregnant goats of a Brucella melitensis Deltaomp25 deletion mutant. Res Vet Sci , 72(3): 235-239
doi: 10.1053/rvsc.2002.0555 pmid:12076120
|
| 74 |
Eker A, Uzunca I, Tansel O, Birtane M (2011). A patient with brucellar cervical spondylodiscitis complicated by epidural abscess. J Clin Neurosci , 18(3): 428-430
doi: 10.1016/j.jocn.2010.06.013 pmid:21239174
|
| 75 |
el Idrissi A H, Benkirane A, el Maadoudi M, Bouslikhane M, Berrada J, Zerouali A (2001). Comparison of the efficacy of Brucella abortus strain RB51 and Brucella melitensis Rev. 1 live vaccines against experimental infection with Brucella melitensis in pregnant ewes. Rev Sci Tech , 20(3): 741-747
pmid:11732416
|
| 76 |
Elberg S S, Faunce K J Jr (1957). Immunization against Brucella infection. VI. Immunity conferred on goats by a nondependent mutant from a streptomycin-dependent mutant strain of Brucella melitensis. J Bacteriol , 73(2): 211-217
pmid:13416171
|
| 77 |
Elzer P H, Edmonds M D, Hagius S D, Walker J V, Gilsdorf M J, Davis D S (1998). Safety of Brucella abortus strain RB51 in Bison. J Wildl Dis , 34(4): 825-829
pmid:9813857
|
| 78 |
Entessar F, Ardalan A, Ebadi A, Jones L M (1967). Effect of living Rev. 1 vaccine in producing long-term immunity against Brucella melitensis infection in sheep in Iran. J Comp Pathol , 77(4): 367-376
doi: 10.1016/0021-9975(67)90021-7 pmid:5625649
|
| 79 |
Eschenbrenner M, Horn T A, Wagner M A, Mujer C V, Miller-Scandle T L, DelVecchio V G (2006). Comparative proteome analysis of laboratory grown Brucella abortus 2308 and Brucella melitensis 16M. J Proteome Res , 5(7): 1731-1740
doi: 10.1021/pr060135p pmid:16823981
|
| 80 |
Fensterbank R, Pardon P, Marly J (1982). Efficacy of Brucella melitensis Rev. 1 vaccine against Brucella ovis infection in rams. Ann Rech Vet , 13(2): 185-190
pmid:7168540
|
| 81 |
Ferguson G P, Datta A, Baumgartner J, Roop R M 2nd, Carlson R W, Walker G C (2004). Similarity to peroxisomal-membrane protein family reveals that Sinorhizobium and Brucella BacA affect lipid-A fatty acids. Proc Natl Acad Sci USA , 101(14): 5012-5017
doi: 10.1073/pnas.0307137101 pmid:15044696
|
| 82 |
Ferrero M C, Fossati C A, Baldi P C (2009). Smooth Brucella strains invade and replicate in human lung epithelial cells without inducing cell death. Microbes Infect , 11(4): 476-483
doi: 10.1016/j.micinf.2009.01.010 pmid:19397873
|
| 83 |
Fiorentino M A, Campos E, Cravero S, Arese A, Paolicchi F, Campero C, Rossetti O (2008). Protection levels in vaccinated heifers with experimental vaccines Brucella abortus M1-luc and INTA 2. Vet Microbiol , 132(3-4): 302-311
doi: 10.1016/j.vetmic.2008.05.003 pmid:18565697
|
| 84 |
Fosgate G T, Adesiyun A A, Hird D W, Johnson W O, Hietala S K, Schurig G G, Ryan J, Diptee M D (2003). Evaluation of brucellosis RB51 vaccine for domestic water buffalo (Bubalus bubalis) in Trinidad. Prev Vet Med , 58(3-4): 211-225
doi: 10.1016/S0167-5877(03)00048-5 pmid:12706059
|
| 85 |
Foulongne V, Walravens K, Bourg G, Boschiroli M L, Godfroid J, Ramuz M, O’Callaghan D (2001). Aromatic compound-dependent Brucella suis is attenuated in both cultured cells and mouse models. Infect Immun , 69(1): 547-550
doi: 10.1128/IAI.69.1.547-550.2001 pmid:11119550
|
| 86 |
Franco M P, Mulder M, Gilman R H, Smits H L (2007). Human brucellosis. Lancet Infect Dis , 7(12): 775-786
doi: 10.1016/S1473-3099(07)70286-4 pmid:18045560
|
| 87 |
Galindo R C, Mu?oz P M, de Miguel M J, Marin C M, Labairu J, Revilla M, Blasco J M, Gortazar C, de la Fuente J (2010). Gene expression changes in spleens of the wildlife reservoir species, Eurasian wild boar (Sus scrofa), naturally infected with Brucella suis biovar 2. J Genet Genomics , 37(11): 725-736
doi: 10.1016/S1673-8527(09)60090-4 pmid:21115167
|
| 88 |
García-Carrillo C (1980). Comparison of B. melitensis Rev. 1 and B. abortus strain 19 as a vaccine against brucellosis in cattle. Zentralbl Veterinarmed B , 27(2): 131-138
doi: 10.1111/j.1439-0450.1980.tb01646.x pmid:6781179
|
| 89 |
González D, Grilló M J, De Miguel M J, Ali T, Arce-Gorvel V, Delrue R M, Conde-Alvarez R, Mu?oz P, López-Go?i I, Iriarte M, Marín C M, Weintraub A, Widmalm G, Zygmunt M, Letesson J J, Gorvel J P, Blasco J M, Moriyón I (2008). Brucellosis vaccines: assessment of Brucella melitensis lipopolysaccharide rough mutants defective in core and O-polysaccharide synthesis and export. PLoS ONE , 3(7): e2760
doi: 10.1371/journal.pone.0002760 pmid:18648644
|
| 90 |
Graves R R (1943). The story of John M. Buck's and Matilda's contribution to the cattle industry. J Am Vet Med Assoc , 102: 193-195
|
| 91 |
Gulsun S, Aslan S, Satici O, Gul T (2011). Brucellosis in pregnancy. Trop Doct , 41(2): 82-84
doi: 10.1258/td.2011.100386 pmid:21378061
|
| 92 |
Haag A F, Myka K K, Arnold M F, Caro-Hernández P, Ferguson G P (2010). Importance of lipopolysaccharide and cyclic β-1,2-glucans in Brucella-mammalian infections. Int J Microbiol , 2010: 1-12
doi: 10.1155/2010/124509 pmid:21151694
|
| 93 |
Hall W H (1990). Modern chemotherapy for brucellosis in humans. Rev Infect Dis , 12(6): 1060-1099
doi: 10.1093/clinids/12.6.1060 pmid:2267485
|
| 94 |
Halling S M, Peterson-Burch B D, Bricker B J, Zuerner R L, Qing Z, Li L L, Kapur V, Alt D P, Olsen S C (2005). Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis. J Bacteriol , 187(8): 2715-2726
doi: 10.1128/JB.187.8.2715-2726.2005 pmid:15805518
|
| 95 |
Herrera E, Rivera A, Palomares E G, Hernández-Castro R, Díaz-Aparicio E (2011). Isolation of Brucella melitensis from a RB51-vaccinated seronegative goat. Trop Anim Health Prod , 43(6): 1069-1070
doi: 10.1007/s11250-011-9822-4 pmid:21455694
|
| 96 |
Hofer E, Revilla-Fernández S, Al Dahouk S, Riehm J M, N?ckler K, Zygmunt M S, Cloeckaert A, Tomaso H, Scholz H C (2011). A potential novel Brucella species isolated from mandibular lymph nodes of red foxes in Austria. Vet Microbiol , (In press)
pmid:21908110
|
| 97 |
Jelastopulu E, Bikas C, Petropoulos C, Leotsinidis M (2008). Incidence of human brucellosis in a rural area in Western Greece after the implementation of a vaccination programme against animal brucellosis. BMC Public Health , 8(1): 241-245
doi: 10.1186/1471-2458-8-241 pmid:18173844
|
| 98 |
Jiménez de Bagüés M P, Barberán M, Marín C M, Blasco J M (1995). The Brucella abortus RB51 vaccine does not confer protection against Brucella ovis in rams. Vaccine , 13(3): 301-304
doi: 10.1016/0264-410X(95)93317-3 pmid:7631517
|
| 99 |
Jiménez de Bagués M P, Marín C M, Barberán M, Blasco J M (1989). Responses of ewes to B. melitensis Rev1 vaccine administered by subcutaneous or conjunctival routes at different stages of pregnancy. Ann Rech Vet , 20(2): 205-213
pmid:2751232
|
| 100 |
Kaushik P, Singh D K, Kumar S V, Tiwari A K, Shukla G, Dayal S, Chaudhuri P (2010). Protection of mice against Brucella abortus 544 challenge by vaccination with recombinant OMP28 adjuvanted with CpG oligonucleotides. Vet Res Commun , 34(2): 119-132
doi: 10.1007/s11259-009-9337-x pmid:20013309
|
| 101 |
Keller R, Hilton T D, Rios H, Boedeker E C, Kaper J B (2010). Development of a live oral attaching and effacing Escherichia coli vaccine candidate using Vibrio cholerae CVD 103-HgR as antigen vector. Microb Pathog , 48(1): 1-8
doi: 10.1016/j.micpath.2009.10.005 pmid:19878715
|
| 102 |
Kim S, Lee D S, Watanabe K, Furuoka H, Suzuki H, Watarai M (2005). Interferon-γ promotes abortion due to Brucella infection in pregnant mice. BMC Microbiol , 5(1): 1-11
doi: 10.1186/1471-2180-5-22 pmid:15649330
|
| 103 |
Kojouri G A, Gholami M (2009). Post vaccination follow-up of Brucella melitensis in blood stream of sheep by PCR assay. Comp Clin Pathol , 18(4): 439-442
doi: 10.1007/s00580-009-0828-5
|
| 104 |
Kolar J (1977). Brucella vaccines production in Mongolia. World Health Organization, Assignment Report on WHO Project MOG BLG 001, SEA/Vaccine/89 , 40
|
| 105 |
Kreeger T J, Cook W E, Edwards W H, Elzer P H, Olsen S C (2002). Brucella abortus strain RB51 vaccination in elk. II. Failure of high dosage to prevent abortion. J Wildl Dis , 38(1): 27-31
pmid:11838225
|
| 106 |
Kreeger T J, Miller M W, Wild M A, Elzer P H, Olsen S C (2000). Safety and efficacy of Brucella abortus strain RB51 vaccine in captive pregnant elk. J Wildl Dis , 36(3): 477-483
pmid:10941732
|
| 107 |
Kurar E, Splitter G A (1997). Nucleic acid vaccination of Brucella abortus ribosomal L7/L12 gene elicits immune response. Vaccine , 15(17-18): 1851-1857
doi: 10.1016/S0264-410X(97)00140-0 pmid:9413093
|
| 108 |
Lavigne J P, Patey G, Sangari F J, Bourg G, Ramuz M, O’Callaghan D, Michaux-Charachon S (2005). Identification of a new virulence factor, BvfA, in Brucella suis. Infect Immun , 73(9): 5524-5529
doi: 10.1128/IAI.73.9.5524-5529.2005 pmid:16113268
|
| 109 |
Levine M M, Ferreccio C, Abrego P, Martin O S, Ortiz E, Cryz S (1999). Duration of efficacy of Ty21a, attenuated Salmonella typhi live oral vaccine. Vaccine , 17(Suppl 2): S22-S27
doi: 10.1016/S0264-410X(99)00231-5 pmid:10506405
|
| 110 |
Li Y K (1988). [A study on one strain of Brucella canis isolated from a cow at the first time]. Zhonghua Liu Xing Bing Xue Za Zhi , 9(6): 342-344
pmid:3245961
|
| 111 |
Loisel-Meyer S, Jiménez de Bagüés M P, Bassères E, Dornand J, K?hler S, Liautard J P, Jubier-Maurin V (2006). Requirement of norD for Brucella suis virulence in a murine model of in vitro and in vivo infection. Infect Immun , 74(3): 1973-1976
doi: 10.1128/IAI.74.3.1973-1976.2006 pmid:16495577
|
| 112 |
Lord V R, Schurig G G, Cherwonogrodzky J W, Marcano M J, Melendez G E (1998). Field study of vaccination of cattle with Brucella abortus strains RB51 and 19 under high and low disease prevalence. Am J Vet Res , 59(8): 1016-1020
pmid:9706206
|
| 113 |
Manthei C A (1959). Summary of controlled research with strain 19. Proc Annu Meet US Livest Sanit Assoc , 63: 91-97
|
| 114 |
Marín C M, Moreno E, Moriyón I, Díaz R, Blasco J M (1999). Performance of competitive and indirect enzyme-linked immunosorbent assays, gel immunoprecipitation with native hapten polysaccharide, and standard serological tests in diagnosis of sheep brucellosis. Clin Diagn Lab Immunol , 6(2): 269-272
pmid:10066666
|
| 115 |
Martínez de Tejada G, Pizarro-Cerdá J, Moreno E, Moriyón I (1995). The outer membranes of Brucella spp. are resistant to bactericidal cationic peptides. Infect Immun , 63(8): 3054-3061
pmid:7622230
|
| 116 |
Memish Z, Mah M W, Al Mahmoud S, Al Shaalan M, Khan M Y (2000). Brucella bacteraemia: clinical and laboratory observations in 160 patients. J Infect , 40(1): 59-63
doi: 10.1053/jinf.1999.0586 pmid:10762113
|
| 117 |
Minas A, Minas M, Stournara A, Tselepidis S (2004). The “effects” of Rev-1 vaccination of sheep and goats on human brucellosis in Greece. Prev Vet Med , 64(1): 41-47
doi: 10.1016/j.prevetmed.2004.03.007 pmid:15219968
|
| 118 |
Mingle C K, Manthei C A, Jasmin A M (1941). The stability of reduced virulence exhibited by Brucella abortus strain 19. J Am Vet Med Assoc , 99: 203-204
|
| 119 |
Moreno E, Moriyón I (2001). Genus Brucella. In Dworkin (ed.), The procaryotes: an evolving microbiological resource for the microbiological community. Springer , New York, NY
|
| 120 |
Moriyón I, Grilló M J, Monreal D, González D, Marín C, López-Go?i I, Mainar-Jaime R C, Moreno E, Blasco J M (2004). Rough vaccines in animal brucellosis: structural and genetic basis and present status. Vet Res , 35(1): 1-38
doi: 10.1051/vetres:2003037 pmid:15099501
|
| 121 |
Mukherjee F, Jain J, Grilló M J, Blasco J M, Nair M (2005). Evaluation of Brucella abortus S19 vaccine strains by bacteriological tests, molecular analysis of ery loci and virulence in BALB/c mice. Biologicals , 33(3): 153-160
doi: 10.1016/j.biologicals.2005.04.003 pmid:16081301
|
| 122 |
Mu?oz P M, de Miguel M J, Grilló M J, Marín C M, Barberán M, Blasco J M (2008). Immunopathological responses and kinetics of Brucella melitensis Rev 1 infection after subcutaneous or conjunctival vaccination in rams. Vaccine , 26(21): 2562-2569
doi: 10.1016/j.vaccine.2008.03.030 pmid:18423950
|
| 123 |
Mu?oz-Montesino C, Andrews E, Rivers R, González-Smith A, Moraga-Cid G, Folch H, Céspedes S, O?ate A A (2004). Intraspleen delivery of a DNA vaccine coding for superoxide dismutase (SOD) of Brucella abortus induces SOD-specific CD4+ and CD8+ T cells. Infect Immun , 72(4): 2081-2087
doi: 10.1128/IAI.72.4.2081-2087.2004 pmid:15039330
|
| 124 |
O’Callaghan D, Maskell D, Liew F Y, Easmon C S, Dougan G (1988). Characterization of aromatic- and purine-dependent Salmonella typhimurium: attention, persistence, and ability to induce protective immunity in BALB/c mice. Infect Immun , 56(2): 419-423
pmid:3276625
|
| 125 |
Olsen S C (2010). Brucellosis in the United States: role and significance of wildlife reservoirs. Vaccine , 28(Suppl 5): F73-F76
doi: 10.1016/j.vaccine.2010.03.059 pmid:20362627
|
| 126 |
Olsen S C, Boyle S M, Schurig G G, Sriranganathan N N (2009). Immune responses and protection against experimental challenge after vaccination of bison with Brucella abortus strain RB51 or RB51 overexpressing superoxide dismutase and glycosyltransferase genes. Clin Vaccine Immunol , 16(4): 535-540
doi: 10.1128/CVI.00419-08 pmid:19176693
|
| 127 |
Olsen S C, Fach S J, Palmer M V, Sacco R E, Stoffregen W C, Waters W R (2006). Immune responses of elk to initial and booster vaccinations with Brucella abortus strain RB51 or 19. Clin Vaccine Immunol , 13(10): 1098-1103
doi: 10.1128/CVI.00213-06 pmid:17028213
|
| 128 |
Olsen S C, Hennager S G (2010). Immune responses and protection against experimental Brucella suis biovar 1 challenge in nonvaccinated or B. abortus strain RB51-vaccinated cattle. Clin Vaccine Immunol , 17(12): 1891-1895
doi: 10.1128/CVI.00326-10 pmid:20943881
|
| 129 |
Olsen S C, Holland S D (2003). Safety of revaccination of pregnant bison with Brucella abortus strain RB51. J Wildl Dis , 39(4): 824-829
pmid:14733277
|
| 130 |
Olsen S C, Jensen A E, Stoffregen W C, Palmer M V (2003). Efficacy of calfhood vaccination with Brucella abortus strain RB51 in protecting bison against brucellosis. Res Vet Sci , 74(1): 17-22
doi: 10.1016/S0034-5288(02)00146-7 pmid:12507562
|
| 131 |
O?ate A A, Donoso G, Moraga-Cid G, Folch H, Céspedes S, Andrews E (2005). An RNA vaccine based on recombinant Semliki Forest virus particles expressing the Cu,Zn superoxide dismutase protein of Brucella abortus induces protective immunity in BALB/c mice. Infect Immun , 73(6): 3294-3300
doi: 10.1128/IAI.73.6.3294-3300.2005 pmid:15908354
|
| 132 |
Osorio M, Wu Y, Singh S, Merkel T J, Bhattacharyya S, Blake M S, Kopecko D J (2009). Anthrax protective antigen delivered by Salmonella enterica serovar Typhi Ty21a protects mice from a lethal anthrax spore challenge. Infect Immun , 77(4): 1475-1482
doi: 10.1128/IAI.00828-08 pmid:19179420
|
| 133 |
Palmer M V, Cheville N F, Jensen A E (1996a). Experimental infection of pregnant cattle with the vaccine candidate Brucella abortus strain RB51: pathologic, bacteriologic, and serologic findings. Vet Pathol , 33(6): 682-691
doi: 10.1177/030098589603300607 pmid:8952027
|
| 134 |
Palmer M V, Olsen S C, Gilsdorf M J, Philo L M, Clarke P R, Cheville N F (1996b). Abortion and placentitis in pregnant bison (Bison bison) induced by the vaccine candidate, Brucella abortus strain RB51. Am J Vet Res , 57(11): 1604-1607
pmid:8915438
|
| 135 |
Pappas G, Akritidis N, Bosilkovski M, Tsianos E (2005). Brucellosis. N Engl J Med , 352(22): 2325-2336
doi: 10.1056/NEJMra050570 pmid:15930423
|
| 136 |
Pappas G, Panagopoulou P, Christou L, Akritidis N (2006a). Brucella as a biological weapon. Cell Mol Life Sci , 63(19-20): 2229-2236
doi: 10.1007/s00018-006-6311-4 pmid:16964579
|
| 137 |
Pappas G, Papadimitriou P, Akritidis N, Christou L, Tsianos E V (2006b). The new global map of human brucellosis. Lancet Infect Dis , 6(2): 91-99
doi: 10.1016/S1473-3099(06)70382-6 pmid:16439329
|
| 138 |
Pasquevich K A, Estein S M, García Samartino C, Zwerdling A, Coria L M, Barrionuevo P, Fossati C A, Giambartolomei G H, Cassataro J (2009). Immunization with recombinant Brucella species outer membrane protein Omp16 or Omp19 in adjuvant induces specific CD4+ and CD8+ T cells as well as systemic and oral protection against Brucella abortus infection. Infect Immun , 77(1): 436-445
doi: 10.1128/IAI.01151-08 pmid:18981242
|
| 139 |
Petrovska L, Hewinson R G, Dougan G, Maskell D J, Woodward M J (1999). Brucella melitensis 16M: characterisation of the galE gene and mouse immunisation studies with a galE deficient mutant. Vet Microbiol , 65(1): 21-36
doi: 10.1016/S0378-1135(98)00281-8 pmid:10068125
|
| 140 |
Phillips R W, Elzer P H, Robertson G T, Hagius S D, Walker J V, Fatemi M B, Enright F M, Roop R M 2nd (1997). A Brucella melitensis high-temperature-requirement A (htrA) deletion mutant is attenuated in goats and protects against abortion. Res Vet Sci , 63(2): 165-167
doi: 10.1016/S0034-5288(97)90012-6 pmid:9429252
|
| 141 |
Pishva E, Salehi M (2008). First report of isolation of Brucella melitensis, vaccine strain Rev.1 as a source of cattle infection in Iran. J Sci Islam Repub Iran , 19: 19-23
|
| 142 |
Poester, F.P., Goncalves, V.S., Paixao, T.A., Santos, R.L., Olsen, S.C., Schurig, G.G., and Lage, A.P. (2006). Efficacy of strain RB51 vaccine in heifers against experimental brucellosis. Vaccine , 24: 5327-5334
|
| 143 |
Pontes D S, Dorella F A, Ribeiro L A, Miyoshi A, Le Loir Y, Gruss A, Oliveira S C, Langella P, Azevedo V (2003). Induction of partial protection in mice after oral administration of Lactococcus lactis producing Brucella abortus L7/L12 antigen. J Drug Target , 11(8-10): 489-493
doi: 10.1080/10611860410001670035 pmid:15203917
|
| 144 |
Pourbagher M A, Pourbagher A, Savas L, Turunc T, Demiroglu Y Z, Erol I, Yalcintas D (2006). Clinical pattern and abdominal sonographic findings in 251 cases of brucellosis in southern Turkey. AJR Am J Roentgenol , 187(2): W191-4
doi: 10.2214/AJR.05.0241 pmid:16861510
|
| 145 |
Pugh G W J Jr, Tabatabai L B, Bricker B J, Mayfield J E, Phillips M, Zehr E S, Belzer C A (1990). Immunogenicity of Brucella-extracted and recombinant protein vaccines in CD-1 and BALB/c mice. Am J Vet Res , 51(9): 1413-1420
pmid:2118744
|
| 146 |
Radwan A I, Bekairi S I, Mukayel A A, al-Bokmy A M, Prasad P V, Azar F N, Coloyan E R (1995). Control of Brucella melitensis infection in a large camel herd in Saudi Arabia using antibiotherapy and vaccination with Rev. 1 vaccine. Rev Sci Tech , 14(3): 719-732
pmid:8593404
|
| 147 |
Rafiei A, Ardestani S K, Kariminia A, Keyhani A, Mohraz M, Amirkhani A (2006). Dominant Th1 cytokine production in early onset of human brucellosis followed by switching towards Th2 along prolongation of disease. J Infect , 53(5): 315-324
doi: 10.1016/j.jinf.2005.11.024 pmid:16488475
|
| 148 |
Rajasekaran P, Surendran N, Seleem M N, Sriranganathan N, Schurig G G, Boyle S M (2011). Over-expression of homologous antigens in a leucine auxotroph of Brucella abortus strain RB51 protects mice against a virulent B. suis challenge. Vaccine , 29(17): 3106-3110
doi: 10.1016/j.vaccine.2011.02.054 pmid:21376799
|
| 149 |
Rajashekara G, Krepps M, Eskra L, Mathison A, Montgomery A, Ishii Y, Splitter G (2005). Unraveling Brucella genomics and pathogenesis in immunocompromised IRF-1-/- mice. Am J Reprod Immunol , 54(6): 358-368
doi: 10.1111/j.1600-0897.2005.00329.x pmid:16305661
|
| 150 |
Robertson G T, Elzer P H, Roop R M 2nd (1996). In vitro and in vivo phenotypes resulting from deletion of the high temperature requirement A (htrA) gene from the bovine vaccine strain Brucella abortus S19. Vet Microbiol , 49(3-4): 197-207
doi: 10.1016/0378-1135(96)84554-8 pmid:8734637
|
| 151 |
Roop R M 2nd, Jeffers G, Bagchi T, Walker J, Enright F M, Schurig G G (1991). Experimental infection of goat fetuses in utero with a stable, rough mutant of Brucella abortus. Res Vet Sci , 51(2): 123-127
doi: 10.1016/0034-5288(91)90001-5 pmid:1788475
|
| 152 |
Roop R M 2nd, Phillips R W, Hagius S, Walker J V, Booth N J, Fulton W T, Edmonds M D, Elzer P H (2001). Re-examination of the role of the Brucella melitensis HtrA stress response protease in virulence in pregnant goats. Vet Microbiol , 82(1): 91-95
doi: 10.1016/S0378-1135(01)00380-7 pmid:11423199
|
| 153 |
Roth F, Zinsstag J, Orkhon D, Chimed-Ochir G, Hutton G, Cosivi O, Carrin G, Otte J (2003). Human health benefits from livestock vaccination for brucellosis: case study. Bull World Health Organ , 81(12): 867-876
pmid:14997239
|
| 154 |
Sangari F J, Agüero J (1994). Identification of Brucella abortus B19 vaccine strain by the detection of DNA polymorphism at the ery locus. Vaccine , 12(5): 435-438
doi: 10.1016/0264-410X(94)90121-X pmid:7912870
|
| 155 |
Sangari F J, García-Lobo J M, Agüero J (1994). The Brucella abortus vaccine strain B19 carries a deletion in the erythritol catabolic genes. FEMS Microbiol Lett , 121(3): 337-342
doi: 10.1111/j.1574-6968.1994.tb07123.x pmid:7926690
|
| 156 |
Schlabritz-Loutsevitch N E, Whatmore A M, Quance C R, Koylass M S, Cummins L B, Dick E J Jr, Snider C L, Cappelli D, Ebersole J L, Nathanielsz P W, Hubbard G B (2009). A novel Brucella isolate in association with two cases of stillbirth in non-human primates- first report. J Med Primatol , 38(1): 70-73
doi: 10.1111/j.1600-0684.2008.00314.x pmid:19187435
|
| 157 |
Schurig G G, Roop R M 2nd, Bagchi T, Boyle S, Buhrman D, Sriranganathan N (1991). Biological properties of RB51; a stable rough strain of Brucella abortus. Vet Microbiol , 28(2): 171-188
doi: 10.1016/0378-1135(91)90091-S pmid:1908158
|
| 158 |
SCOFCAH (2011). Portugal: Results of the implementation of the sheep and goat brucellosis eradication programme 2010 Standing Committee on the Food Chain and Animal Health (SCOFCAH), Brusselshttp://ec.europa.eu/food/committees/regulatory/scfcah/animal_health/presentations/0708092011_brucellosis_portugal.pdf
|
| 159 |
Scurlock B M, Edwards W H (2010). Status of brucellosis in free-ranging elk and bison in Wyoming. J Wildl Dis , 46(2): 442-449
pmid:20688637
|
| 160 |
Shi D, Song Y, Li Y J (2006). [Progress on lactococcus lactis expressing heterologous antigens as live mucosal vaccines]. Wei Sheng Wu Xue Bao , 46(4): 680-683
pmid:17037080
|
| 161 |
Silva T M, Costa E A, Paix?o T A, Tsolis R M, Santos R L (2011a). Laboratory animal models for brucellosis research. J Biomed Biotechnol , 2011: 518323
doi: 10.1155/2011/518323 pmid:21403904
|
| 162 |
Silva T M, Paix?o T A, Costa E A, Xavier M N, Sá J C, Moustacas V S, den Hartigh A B, Carvalho Neta A V, Oliveira S C, Tsolis R, Santos R L (2011b). Putative ATP-binding cassette transporter is essential for Brucella ovis pathogenesis in mice. Infect Immun , 79(4): 1706-1717
doi: 10.1128/IAI.01109-10 pmid:21300772
|
| 163 |
Smith L D, Ficht T A (1990). Pathogenesis of Brucella. Crit Rev Microbiol , 17(3): 209-230
doi: 10.3109/10408419009105726 pmid:2154232
|
| 164 |
Smither S J, Perkins S D, Davies C, Stagg A J, Nelson M, Atkins H S (2009). Development and characterization of mouse models of infection with aerosolized Brucella melitensis and Brucella suis. Clin Vaccine Immunol , 16(5): 779-783
doi: 10.1128/CVI.00029-09 pmid:19321692
|
| 165 |
Spink W W, Hall J W 3rd, Finstad J, Mallet E (1962). Immunization with viable Brucella organisms. Results of a safety test in humans. Bull World Health Organ , 26: 409-419
pmid:13915813
|
| 166 |
Stabel T J, Mayfield J E, Morfitt D C, Wannemuehler M J (1993). Oral immunization of mice and swine with an attenuated Salmonella choleraesuis [delta cya-12 delta(crp-cdt)19] mutant containing a recombinant plasmid. Infect Immun , 61(2): 610-618
pmid:8423090
|
| 167 |
Stabel T J, Mayfield J E, Tabatabai L B, Wannemuehler M J (1990). Oral immunization of mice with attenuated Salmonella typhimurium containing a recombinant plasmid which codes for production of a 31-kilodalton protein of Brucella abortus. Infect Immun , 58(7): 2048-2055
pmid:2114357
|
| 168 |
Stabel T J, Mayfield J E, Tabatabai L B, Wannemuehler M J (1991). Swine immunity to an attenuated Salmonella typhimurium mutant containing a recombinant plasmid which codes for production of a 31-kilodalton protein of Brucella abortus. Infect Immun , 59(9): 2941-2947
pmid:1908827
|
| 169 |
Stevens M G, Hennager S G, Olsen S C, Cheville N F (1994). Serologic responses in diagnostic tests for brucellosis in cattle vaccinated with Brucella abortus 19 or RB51. J Clin Microbiol , 32(4): 1065-1066
pmid:8027313
|
| 170 |
Stevens M G, Olsen S C (1996). Antibody responses to Brucella abortus 2308 in cattle vaccinated with B. abortus RB51. Infect Immun , 64(3): 1030-1034
pmid:8641754
|
| 171 |
Stevens M G, Olsen S C, Cheville N F (1995a). Comparative analysis of immune responses in cattle vaccinated with Brucella abortus strain 19 or strain RB51. Vet Immunol Immunopathol , 44(3-4): 223-235
doi: 10.1016/0165-2427(94)05311-F pmid:7747403
|
| 172 |
Stevens M G, Olsen S C, Pugh G W Jr, Brees D (1995b). Comparison of immune responses and resistance to brucellosis in mice vaccinated with Brucella abortus 19 or RB51. Infect Immun , 63(1): 264-270
pmid:7806364
|
| 173 |
Taylor A W, McDiarmid A (1949). The stability of the avirulent characters of Brucella abortus, strain 19 and strain 45/20 in lactating and pregnant cows. Vet Rec , 61: 317-318
|
| 174 |
Teske S S, Huang Y, Tamrakar S B, Bartrand T A, Weir M H, Haas C N (2011). Animal and human dose-response models for Brucella species. Risk Anal , 31(10): 1576-1596
doi: 10.1111/j.1539-6924.2011.01602.x pmid:21449960
|
| 175 |
Thorne E T (1997). Brucellosis, bison, elk, and cattle in the Greater Yellowstone area: defining the problem, exploring solutions. Cheyenne, Wyoming Game and Fish Dept. for Greater Yellowstone Interagency Brucellosis Committee
|
| 176 |
Tibor A, Jacques I, Guilloteau L, Verger J M, Grayon M, Wansard V, Letesson J J (1998). Effect of P39 gene deletion in live Brucella vaccine strains on residual virulence and protective activity in mice. Infect Immun , 66(11): 5561-5564
pmid:9784574
|
| 177 |
Trant C G, Lacerda T L, Carvalho N B, Azevedo V, Rosinha G M, Salcedo S P, Gorvel J P, Oliveira S C (2010). The Brucella abortus phosphoglycerate kinase mutant is highly attenuated and induces protection superior to that of vaccine strain 19 in immunocompromised and immunocompetent mice. Infect Immun , 78(5): 2283-2291
doi: 10.1128/IAI.01433-09 pmid:20194591
|
| 178 |
Treanor J J, Johnson J S, Wallen R L, Cilles S, Crowley P H, Cox J J, Maehr D S, White P J, Plumb G E (2010). Vaccination strategies for managing brucellosis in Yellowstone bison. Vaccine , 28(Suppl 5): F64-F72
doi: 10.1016/j.vaccine.2010.03.055 pmid:20362620
|
| 179 |
Ugalde J E, Comerci D J, Leguizamón M S, Ugalde R A (2003). Evaluation of Brucella abortus phosphoglucomutase (pgm) mutant as a new live rough-phenotype vaccine. Infect Immun , 71(11): 6264-6269
doi: 10.1128/IAI.71.11.6264-6269.2003 pmid:14573645
|
| 180 |
Valderas M W, Barrow W W (2008). Establishment of a method for evaluating intracellular antibiotic efficacy in Brucella abortus-infected Mono Mac 6 monocytes. J Antimicrob Chemother , 61(1): 128-134
doi: 10.1093/jac/dkm433 pmid:18024491
|
| 181 |
Van Campen H, Rhyan J (2010). The role of wildlife in diseases of cattle. Vet Clin North Am Food Anim Pract , 26(1): 147-161
doi: 10.1016/j.cvfa.2009.10.008 pmid:20117548
|
| 182 |
Velikovsky C A, Cassataro J, Giambartolomei G H, Goldbaum F A, Estein S, Bowden R A, Bruno L, Fossati C A, Spitz M (2002). A DNA vaccine encoding lumazine synthase from Brucella abortus induces protective immunity in BALB/c mice. Infect Immun , 70(5): 2507-2511
doi: 10.1128/IAI.70.5.2507-2511.2002 pmid:11953389
|
| 183 |
Vemulapalli R, Contreras A, Sanakkayala N, Sriranganathan N, Boyle S M, Schurig G G (2004). Enhanced efficacy of recombinant Brucella abortus RB51 vaccines against B. melitensis infection in mice. Vet Microbiol , 102(3-4): 237-245
doi: 10.1016/j.vetmic.2004.07.001 pmid:15327798
|
| 184 |
Verger J M, Grayon M, Zundel E, Lechopier P, Olivier-Bernardin V (1995). Comparison of the efficacy of Brucella suis strain 2 and Brucella melitensis Rev. 1 live vaccines against a Brucella melitensis experimental infection in pregnant ewes. Vaccine , 13(2): 191-196
doi: 10.1016/0264-410X(95)93135-V pmid:7625115
|
| 185 |
Walker, G.C., LeVier, K., Phillips, R.W., Grippe, V.K., and Roop, R.M., 2nd. (2000). Similar requirements of a plant symbiont and a mammalian pathogen for prolonged intracellular survival. Science , 287: 2492-2493
|
| 186 |
Wang Y, Bai Y, Qu Q, Xu J, Chen Y, Zhong Z, Qiu Y, Wang T, Du X, Wang Z, Yu S, Fu S, Yuan J, Zhen Q, Yu Y, Chen Z, Huang L (2011). The 16MΔvjbR as an ideal live attenuated vaccine candidate for differentiation between Brucella vaccination and infection. Vet Microbiol , 151(3-4): 354-362
doi: 10.1016/j.vetmic.2011.03.031 pmid:21530111
|
| 187 |
Ward D, Jackson, R., Karomatullo H, Khakimov T, Kurbonov K, Amirbekov M, Stack J, El-Idrissi A, Heuer C (2011). Brucellosis control in Tajikistan using Rev 1 vaccine: change in seroprevalence in small ruminants from 2004 to 2009. Vet Rec
|
| 188 |
Whatmore A M (2009). Current understanding of the genetic diversity of Brucella, an expanding genus of zoonotic pathogens. Infect Genet Evol , 9(6): 1168-1184
doi: 10.1016/j.meegid.2009.07.001 pmid:19628055
|
| 189 |
Winter A J, Rowe G E, Duncan J R, Eis M J, Widom J, Ganem B, Morein B (1988). Effectiveness of natural and synthetic complexes of porin and O polysaccharide as vaccines against Brucella abortus in mice. Infect Immun , 56(11): 2808-2817
pmid:2844673
|
| 190 |
Wise R I (1980). Brucellosis in the United States. Past, present, and future. JAMA , 244(20): 2318-2322
doi: 10.1001/jama.1980.03310200058031 pmid:7001058
|
| 191 |
Wyckoff J H 3rd, Howland J L, Scott C M, Smith R A, Confer A W (2005). Recombinant bovine interleukin 2 enhances immunity and protection induced by Brucella abortus vaccines in cattle. Vet Microbiol , 111(1-2): 77-87
doi: 10.1016/j.vetmic.2005.09.004 pmid:16242273
|
| 192 |
Xavier M N, Paix?o T A, Poester F P, Lage A P, Santos R L (2009). Pathological, immunohistochemical and bacteriological study of tissues and milk of cows and fetuses experimentally infected with Brucella abortus. J Comp Pathol , 140(2-3): 149-157
doi: 10.1016/j.jcpa.2008.10.004 pmid:19111839
|
| 193 |
Xin X (1986). Orally administrable brucellosis vaccine: Brucella suis strain 2 vaccine. Vaccine , 4(4): 212-216
doi: 10.1016/0264-410X(86)90131-3 pmid:3541425
|
| 194 |
Yang X, Becker T, Walters N, Pascual D W (2006). Deletion of znuA virulence factor attenuates Brucella abortus and confers protection against wild-type challenge. Infect Immun , 74(7): 3874-3879
doi: 10.1128/IAI.01957-05 pmid:16790759
|
| 195 |
Yang X, Hinnebusch B J, Trunkle T, Bosio C M, Suo Z, Tighe M, Harmsen A, Becker T, Crist K, Walters N, Avci R, Pascual D W (2007). Oral vaccination with salmonella simultaneously expressing Yersinia pestis F1 and V antigens protects against bubonic and pneumonic plague. J Immunol , 178(2): 1059-1067
pmid:17202369
|
| 196 |
Yang X, Hudson M, Walters N, Bargatze R F, Pascual D W (2005). Selection of protective epitopes for Brucella melitensis by DNA vaccination. Infect Immun , 73(11): 7297-7303
doi: 10.1128/IAI.73.11.7297-7303.2005 pmid:16239526
|
| 197 |
Yang X, Thornburg T, Walters N, Pascual D W (2010). DeltaznuADeltapurE Brucella abortus 2308 mutant as a live vaccine candidate. Vaccine , 28(4): 1069-1074
doi: 10.1016/j.vaccine.2009.10.113 pmid:19914192
|
| 198 |
Yang Y, Yin J, Guo D, Lang X, Wang X (2011). Immunization of mice with recombinant S-adenosyl-L-homocysteine hydrolase protein confers protection against Brucella melitensis infection. FEMS Immunol Med Microbiol , 61(2): 159-167
doi: 10.1111/j.1574-695X.2010.00758.x pmid:21166726
|
| 199 |
Young E J (1989). Clinical manifestations of human brucellosis, p. 97-126. In E. J. Young and M. J. Corbel (ed.), Brucellosis: clinical and laboratory aspects. CRC Press, Inc, Boca Raton, Fla
|
| 200 |
Yu D H, Hu X D, Cai H, Li M (2007). A combined DNA vaccine encoding BCSP31, SOD, and L7/L12 confers high protection against Brucella abortus 2308 by inducing specific CTL responses. DNA Cell Biol , 26(6): 435-443
doi: 10.1089/dna.2006.0552 pmid:17570767
|
| 201 |
Zhan Y, Cheers C (1993). Endogenous gamma interferon mediates resistance to Brucella abortus infection. Infect Immun , 61(11): 4899-4901
pmid:8406893
|
| 202 |
Zhao Z, Li M, Luo D, Xing L, Wu S, Duan Y, Yang P, Wang X (2009). Protection of mice from Brucella infection by immunization with attenuated Salmonella enterica serovar typhimurium expressing A L7/L12 and BLS fusion antigen of Brucella. Vaccine , 27(38): 5214-5219
doi: 10.1016/j.vaccine.2009.06.075 pmid:19596411
|
| 203 |
Zinsstag J, Roth F, Orkhon D, Chimed-Ochir G, Nansalmaa M, Kolar J, Vounatsou P (2005). A model of animal-human brucellosis transmission in Mongolia. Prev Vet Med , 69(1-2): 77-95
doi: 10.1016/j.prevetmed.2005.01.017 pmid:15899298
|
| 204 |
Zowghi E, Ebadi A (1985). Naturally occurring Brucella melitensis infection in cattle in Iran. Rev Sci Tech Off Int Epiz , 4: 811-814
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