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Frontiers in Biology

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Front. Biol.    2014, Vol. 9 Issue (6) : 437-447    https://doi.org/10.1007/s11515-014-1333-z
REVIEW
Protein secretion systems in bacterial pathogens
Li XU1,*(),Yancheng LIU2,*()
1. Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA
2. Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA
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Abstract

Many bacterial pathogens utilize specialized secretion systems to deliver virulence factors into the extracellular milieu. These exported effectors act to manipulate various processes of targeted cells in order to create a suitable niche for bacterial growth. Currently, seven different types of secretion system have been described, of which Type I – VI are mainly present in Gram-negative bacteria and the newly discovered Type VII system seems exclusive to Gram-positive species. This review summaries our current understanding on the architecture and transport mechanisms of each secretion apparatus. We also discuss recent studies revealing the roles that these secretion systems and their substrates play in microbial pathogenesis.
Keywords bacterial pathogen      secretion system      virulence factors     
Corresponding Author(s): Li XU   
Just Accepted Date: 25 September 2014   Online First Date: 14 November 2014    Issue Date: 13 January 2015
 Cite this article:   
Li XU,Yancheng LIU. Protein secretion systems in bacterial pathogens[J]. Front. Biol., 2014, 9(6): 437-447.
 URL:  
https://academic.hep.com.cn/fib/EN/10.1007/s11515-014-1333-z
https://academic.hep.com.cn/fib/EN/Y2014/V9/I6/437
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