Please wait a minute...
Frontiers in Biology

ISSN 1674-7984

ISSN 1674-7992(Online)

CN 11-5892/Q

Front. Biol.    2018, Vol. 13 Issue (2) : 145-148    https://doi.org/10.1007/s11515-018-1486-2
RESEARCH ARTICLE
Effectiveness of fractional CO2 laser in women with stress urinary incontinence
Mahin Najafian, Yalda Jafrideh, Behnaz Ghazisaeidi()
Fertility, Infertility and Perinatology Research Center, Ahavaz Jundishapur University of Medical Sciences, Ahvaz, Iran
 Download: PDF(159 KB)   HTML
 Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks
Abstract

BACKGROUND: Stress urinary incontinence (SUI) is a relatively common disorder that significantly affects the quality of life. Many conservative and surgical treatment methods have been recommended for SUI, but they have major limitations.

AIMS: To assess the use of the CO2 fractional laser in the treatment of SUI.

METHODS: This clinical trial included 55 patients with confirmed SUI. Patients underwent fractional CO2 laser treatment 3 times at 30-day intervals. Data on age, smoking history, sexual activity, menopause, and history of hormone replacement therapy (HRT) were collected. Response to treatment was assessed by SUI severity and the level of sexual satisfaction was assessed using the visual analog scale (VAS). Patients were evaluated at 3 different time points: before treatment, and 45 days and 6 months after the last laser treatment.

RESULTS: The mean patient age was 44.4±11.4 years (range: 28 to 68 years). Smoking history was positive in 6 patients (9.1%); 19 (54.3%) were menopausal on HRT. The SUI severity score at baseline (before treatment) was 8.56±0.62 and decreased to 2.28 6 months after treatment (p<0.0001). The sexual satisfaction score was 3±0.94 at baseline and increased to 7.87±0.93 6 months after treatment (day 180) (p<0.0001, slope= + 2.2)

CONCLUSION: Our findings are in line with a previous study that showed the value of transvaginal CO2 fractional laser treatment for alleviation of SUI symptoms and its potential as an alternative treatment. We also observed improved sexual satisfaction in SUI patients.

Keywords stress urinary incontinence      CO2 fractional laser      sexual function     
Corresponding Author(s): Behnaz Ghazisaeidi   
Online First Date: 09 May 2018    Issue Date: 28 May 2018
 Cite this article:   
Mahin Najafian,Yalda Jafrideh,Behnaz Ghazisaeidi. Effectiveness of fractional CO2 laser in women with stress urinary incontinence[J]. Front. Biol., 2018, 13(2): 145-148.
 URL:  
https://academic.hep.com.cn/fib/EN/10.1007/s11515-018-1486-2
https://academic.hep.com.cn/fib/EN/Y2018/V13/I2/145
Variables Frequency
Age (mean±s.d) 44.4±11.40 (28–68)
Smoking Yes 6(10.9%)
No 49(89.1%)
Hormone replacement therapy Yes 19(34.5%)
No 36(65.5%)
Menopause Yes 19(34.5%)
No 36(65.5%)
Tab.1  Patient characteristics
Variables Prior treatment After treatment (day 45) After treatment (day 180) p-value
Stress urinary incontinence 8.56±0.62 3.02±0.8 2.28±0.66 p<0.0001
Sexual satisfaction 3±0.94 4.2±1.57 7.87±0.93 p<0.0001
Tab.2  Treatment effects
Fig.1  Changes in SUI severity during study follow-up.
Fig.2  Multiple comparisons of SUI severity at different time points
Fig.3  Changes in sexual satisfaction score during study follow-up.
1 Fistonić N, Fistonić I, Guštek Š F, Turina I S, Marton I, Vižintin Z, Kažič M, Hreljac I, Perhavec T, Lukač M (2016). Minimally invasive, non-ablative Er:YAG laser treatment of stress urinary incontinence in women--a pilot study. Lasers Med Sci, 31(4): 635–643; Epub ahead of print
https://doi.org/10.1007/s10103-016-1884-0 pmid: 26861984
2 Isaza P G, Jaguszewska K, Cardona J L, Lukaszuk M (2017). Long-term effect of thermoablative fractional CO2 laser treatment as a novel approach to urinary incontinence management in women with genitourinary syndrome of menopause. Int Urogynecol J Pelvic Floor Dysfunct, 29 (2) :1–5
3 Kavanagh A, Sanaee M, Carlson K V, Bailly G G (2017). Management of patients with stress urinary incontinence after failed midurethral sling. Can Urol Assoc J, 11(6Suppl2): S143–S146
https://doi.org/10.5489/cuaj.4610 pmid: 28616115
4 Kociszewski J, Fabian G, Grothey S, Kuszka A, Zwierzchowska A, Majkusiak W, Barcz E (2017). Are complications of stress urinary incontinence surgery procedures associated with the position of the sling? Int J Urol, 24(2): 145–150
https://doi.org/10.1111/iju.13262 pmid: 27907976
5 Luber K M (2004). The definition, prevalence, and risk factors for stress urinary incontinence. Rev Urol, 6(Suppl 3): S3–S9
pmid: 16985863
6 Menachem A, Alexander B, Martinec K A, Gutman G (2016). The effect of vaginal CO2 laser treatment on stress urinary incontinence symptoms. Alma Surgical.
7 Nygaard I E, Heit M (2004). Stress urinary incontinence. Obstet Gynecol, 104(3): 607–620
https://doi.org/10.1097/01.AOG.0000137874.84862.94 pmid: 15339776
8 Pardo J I, Solà V R, Morales A A (2016). Treatment of female stress urinary incontinence with Erbium-YAG laser in non-ablative mode. Eur J Obstet Gynecol Reprod Biol, 204: 1–4
https://doi.org/10.1016/j.ejogrb.2016.06.031 pmid: 27448169
9 Park S H, Kang C B (2014). Effect of kegel exercises on the management of female stress urinary incontinence: A systematic review of randomized controlled trials. Advan Nur, 2014 (4) :1–10
10 Pitsouni E, Grigoriadis T, Falagas M E, Salvatore S, Athanasiou S (2017). Laser therapy for the genitourinary syndrome of menopause. A systematic review and meta-analysis. Maturitas, 103: 78–88
https://doi.org/10.1016/j.maturitas.2017.06.029 pmid: 28778337
11 Pitsouni E, Grigoriadis T, Tsiveleka A, Zacharakis D, Salvatore S, Athanasiou S (2016). Microablative fractional CO2-laser therapy and the genitourinary syndrome of menopause: An observational study. Maturitas, 94: 131–136
https://doi.org/10.1016/j.maturitas.2016.09.012 pmid: 27823733
12 Salvatore S, Nappi R E, Parma M, Chionna R, Lagona F, Zerbinati N, Ferrero S, Origoni M, Candiani M, Leone Roberti Maggiore U (2015). Sexual function after fractional microablative CO₂ laser in women with vulvovaginal atrophy. Climacteric, 18(2): 219–225
https://doi.org/10.3109/13697137.2014.975197 pmid: 25333211
13 Ulmsten U, Falconer C (1999). Connective tissue in female urinary incontinence. Curr Opin Obstet Gynecol, 11(5): 509–515
https://doi.org/10.1097/00001703-199910000-00017 pmid: 10526931
14 van Kerrebroeck P, ter Meulen F, Farrelly E, Larsson G, Edwall L, Fianu-Jonasson A (2003). Treatment of stress urinary incontinence: recent developments in the role of urethral injection. Urol Res, 30(6): 356–362
pmid: 12599014
15 Zhou S, Zhang K, Atala A, Khoury O, Murphy SV, Zhao W, Fu Q (2016). Stem cell therapy for treatment of stress urinary incontinence: the current status and challenges. Stem Cell Intern, 2016 (3) :7060975
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed