Zfyve16 regulates the proliferation of B-lymphoid cells

doi:10.1007/s11684-017-0562-3

Frontiers of Medicine

2018, Vol. 12

Issue (5): 559-565 https://doi.org/10.1007/s11684-017-0562-3

本期目录

Zfyve16 regulates the proliferation of B-lymphoid cells

Xuemei Zhao¹, Donghe Li¹, Qingsong Qiu¹, Bo Jiao¹, Ruihong Zhang¹, Ping Liu¹(

), Ruibao Ren^1,²(

)

¹. State Key Laboratory for Medical Genomics, Shanghai Institute of Hematology, Collaborative Innovation Center of Hematology, Collaborative Innovation Center of System Biology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
². Department of Biology, Brandeis University, Waltham, MA 02454, USA

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Abstract：

Zfyve16 (a.k.a. endofin or endosome-associated FYVE-domain protein), a member of the FYVE-domain protein family, is involved in endosomal trafficking and in TGF-β, BMP, and EGFR signaling. The FYVE protein SARA regulates the TGF-β signaling pathway by recruiting Smad2/3 and accelerating their phosphorylation, thereby altering their susceptibility to TGF-β-mediated T cell suppression. Zfyve16 binds to Smad4 and their binding affects the formation of Smad2/3-Smad4 complex in TGF-β signaling. However, the in vivo function of Zfyve16 remains unknown. In this study, we generated a Zfyve16 knockout mouse strain (Zfyve16^KO) and examined its hematopoietic phenotypes and hematopoietic reconstruction ability. The proportion of T cells in the peripheral blood of Zfyve16^KO mice increases compared with that in wild-type mice. This finding is consistent with the role of Zfyve16 in facilitating TGF-β signaling. Unpredictably, B cell proliferation is inhibited in Zfyve16^KO mice. The proliferation potential of Zfyve16^KO B-lymphoid cells also significantly decreases in vitro. These results suggest that Zfyve16 inhibits the proliferation of T cells, possibly through the TGF-β signaling, but upregulates the proliferation of B-lymphoid cells.

Key words： Zfyve16 endofin hematopoiesis TGF-β lymphocytes

收稿日期: 2017-03-20 出版日期: 2018-09-29

Corresponding Author(s): Ping Liu,Ruibao Ren

引用本文:

. [J]. Frontiers of Medicine, 2018, 12(5): 559-565.
Xuemei Zhao, Donghe Li, Qingsong Qiu, Bo Jiao, Ruihong Zhang, Ping Liu, Ruibao Ren. Zfyve16 regulates the proliferation of B-lymphoid cells. Front. Med., 2018, 12(5): 559-565.

链接本文:

https://academic.hep.com.cn/fmd/CN/10.1007/s11684-017-0562-3
https://academic.hep.com.cn/fmd/CN/Y2018/V12/I5/559

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