Prevention and treatment of pancreatic fistula after pancreatic body and tail resection: current status and future directions

doi:10.1007/s11684-019-0727-3

Front. Med.

2020, Vol. 14

Issue (3) : 251-261 https://doi.org/10.1007/s11684-019-0727-3

REVIEW

Prevention and treatment of pancreatic fistula after pancreatic body and tail resection: current status and future directions

Li Jiang¹, Deng Ning¹, Xiao-ping Chen²(

)

¹. Department of Biliary and Pancreatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
². Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

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Abstract

Postoperative pancreatic fistula (POPF) is the most common and critical complication after pancreatic body and tail resection. How to effectively reduce the occurrence of pancreatic fistula and conduct timely treatment thereafter is an urgent clinical issue to be solved. Recent research standardized the definition of pancreatic fistula and stressed the correlation between POPF classification and patient prognosis. According to the literature, identification of the risk factors for pancreatic fistula contributed to lowering the rate of the complication. Appropriate management of the pancreatic stump and perioperative treatment are of great significance to reduce the rate of POPF in clinical practice. After the occurrence of POPF, the treatment of choice should be determined according to the classification of the pancreatic fistula. However, despite the progress and promising treatment approaches, POPF remains to be a clinical issue that warrants further studies in the future.

Keywords pancreatic fistula pancreatic body and tail resection distal pancreatectomy

Corresponding Author(s): Xiao-ping Chen

Just Accepted Date: 19 November 2019 Online First Date: 17 December 2019 Issue Date: 08 June 2020

Cite this article:

Li Jiang,Deng Ning,Xiao-ping Chen. Prevention and treatment of pancreatic fistula after pancreatic body and tail resection: current status and future directions[J]. Front. Med., 2020, 14(3): 251-261.

URL:

https://academic.hep.com.cn/fmd/EN/10.1007/s11684-019-0727-3
https://academic.hep.com.cn/fmd/EN/Y2020/V14/I3/251

Tab.1 Risk factors of postoperative fistula after distal pancreatectomy

Author (year)	Study design	Study group (n)	Postoperative pancreatic fistula (%)	Mortality (%)
Kleeff, 2007 [⁶]	Retrospective	Anastomosis (24) vs. seromuscular patch (36) vs. stapler (145) vs. suture (97)	0 vs. 8.3 vs. 15.9 vs. 9.3	0 vs. 0 vs. 2.8 vs. 2.1
Johnston, 2008 [⁸]	Retrospective	Mesh (70) vs. stapler (44) vs. suture (55)	10 vs. 16 vs. 33	0 vs. 0 vs. 0
Diener, 2011 [³⁹]	Prospective	Stapler (177) vs..suture (36)	36 vs. 37	0 vs. 1
Ban, 2012 [⁷⁷]	Retrospective	Stapler (177) vs. non-stapler (36)	21 vs. 50.6	0 vs. 0
Kawai, 2013 [¹⁰]	Retrospective	Handsewn closure (32) vs. bipolar scissors (45) vs. stapler closure (45)	18.7 vs. 17.7 vs. 11.1	0 vs. 0 vs. 0
Karabicak, 2017 [²²]	Retrospective	DP-TF (89) vs. DP-PG (44) vs. DP-ST (36)	11.3 vs. 20.5 vs. 27.8	2.3 vs. 2.4 vs. 0
Cunha, 2015 [²³]	Prospective	TachoSil (134) vs. non-TachoSil (136)	30.6 vs. 24.3	0.7 vs. 1.5
Hassenpflug, 2012 [²⁵]	Retrospective	Coverage (73) vs. non-coverage (44)	14 vs. 34*	0 vs. 1
Carter, 2012 [²⁶]	Prospective	FF (50) vs. SS (51)	18 vs. 18	0 vs. 0
Hassenpflug, 2016 [²⁷]	Prospective	Coverage (76) vs. non-coverage (76)	22.4 vs. 32.9	0 vs. 1.3
Oláh, 2009 [²⁹]	Prospective	Stapling+ seromuscular patch (35) vs. stapling alone (35)	2.8 vs. 8.6	0 vs. 2.8
Fujii, 2015 [³⁰]	Retrospective	EJ patch (42) vs. non-EJ patch (39)	10 vs. 35	0 vs. 3
Park, 2016 [³³]	Prospective	TachoSil^l®patch (48) vs. control (53)	22.9 vs. 28.3	0 vs. 0
Shubert, 2016 [³⁴]	Prospective	SEAMGUARD (32) vs.TissueLink (35)	12.5 vs. 22.9	0 vs. 0
Kawai, 2017 [⁵¹]	Prospective	Reinforced staplers (105)	12.4	0
Montorsi, 2012 [³²]	Prospective	TachoSil^l® patch (145) vs. standard (130)	8 vs. 14	0 vs. 0
Hamilton, 2012 [⁴⁴]	Prospective	Mesh reinforcement (54) vs. non-staple-line reinforcement (46)	1.9 vs. 20*	1.8 vs. 2.2
Sudo, 2011 [⁴⁸]	Retrospective	Duct-to-mucosa pancreaticogastrostomy (21)	0	0
Yanagimoto, 2013 [⁴⁹]	Retrospective	DP-PG (21) vs. DP (26)	5 vs. 12	0 vs. 4
Klein, 2012 [⁵⁰]	Retrospective	Pancreatoenteral anastomosis (PE) (47) vs. direct closure (DC) (51)	11 vs. 22	2 vs. 4
Kawai, 2015 [⁵¹]	Prospective	Pancreaticojejunostomy (62) vs. stapler closure (61)	9.7 vs. 16.4	0 vs. 0
Uemura, 2016 [⁵²]	Prospective	Duct-to-mucosapancreaticogastrostomy (36) vs. handsewn closure with pancreatic duct ligation (37)	19.4 vs. 18.9	2.7 vs. 0

Tab.2 Reports on the treatment of pancreatic stump

Fig.1 Flow chart of treatment for pancreatic fistula after distal pancreatectomy.

1	WB Pratt, MP Callery, CM Jr Vollmer. The latent presentation of pancreatic fistulas. Br J Surg 2009; 96(6): 641–649 https://doi.org/10.1002/bjs.6614 pmid: 19434658
2	O Facy, C Chalumeau, M Poussier, C Binquet, P Rat, P Ortega-Deballon. Diagnosis of postoperative pancreatic fistula. Br J Surg 2012; 99(8): 1072–1075 https://doi.org/10.1002/bjs.8774 pmid: 22539219
3	C Bassi, C Dervenis, G Butturini, A Fingerhut, C Yeo, J Izbicki, J Neoptolemos, M Sarr, W Traverso, M Buchler; International Study Group on Pancreatic Fistula Definition. Postoperative pancreatic fistula: an international study group (ISGPF) definition. Surgery 2005; 138(1): 8–13 https://doi.org/10.1016/j.surg.2005.05.001 pmid: 16003309
4	C Bassi, G Marchegiani, C Dervenis, M Sarr, M Abu Hilal, M Adham, P Allen, R Andersson, HJ Asbun, MG Besselink, K Conlon, M Del Chiaro, M Falconi, L Fernandez-Cruz, C Fernandez-Del Castillo, A Fingerhut, H Friess, DJ Gouma, T Hackert, J Izbicki, KD Lillemoe, JP Neoptolemos, A Olah, R Schulick, SV Shrikhande, T Takada, K Takaori, W Traverso, CR Vollmer, CL Wolfgang, CJ Yeo, R Salvia, M; International Study Group on Pancreatic Surgery (ISGPS). The 2016 update of the International Study Group (ISGPS) definition and grading of postoperative pancreatic fistula: 11 Years After. Surgery 2017; 161(3): 584–591 https://doi.org/10.1016/j.surg.2016.11.014 pmid: 28040257
5	L Maggino, G Malleo, C Bassi, V Allegrini, MT McMillan, A Borin, B Chen, JA Drebin, BL Ecker, DL Fraker, MK Lee, S Paiella, RE Roses, R Salvia, CM Jr Vollmer. Decoding grade B pancreatic fistula: a clinical and economical analysis and subclassification proposal. Ann Surg 2019; 269(6): 1146–1153 https://doi.org/10.1097/SLA.0000000000002673 pmid: 31082914
6	J Kleeff, MK Diener, Z’ K graggen, U Hinz, M Wagner, J Bachmann, J Zehetner, MW Müller, H Friess, MW Büchler . Distal pancreatectomy: risk factors for surgical failure in 302 consecutive cases. Ann Surg 2007; 245(4): 573–582 https://doi.org/10.1097/01.sla.0000251438.43135.fb pmid: 17414606
7	BK Goh, YM Tan, YF Chung, PC Cheow, HS Ong, WH Chan, PK Chow, KC Soo, WK Wong, LL Ooi. Critical appraisal of 232 consecutive distal pancreatectomies with emphasis on risk factors, outcome, and management of the postoperative pancreatic fistula: a 21-year experience at a single institution.. Arch Surg 2008; 10(143): 956–965 https://doi.org/10.1001/archsurg.143.10.956 pmid: 18936374
8	FM Johnston, A Cavataio, SM Strasberg, NA Hamilton, PO Jr Simon, K Trinkaus, MB Doyle M, BD Mathews, MR Porembka, DC Linehan, WG Hawkins. The effect of mesh reinforcement of a stapled transection line on the rate of pancreatic occlusion failure after distal pancreatectomy: review of a single institution’s experience. HPB (Oxford) 2009; 11(1): 25–31 https://doi.org/10.1111/j.1477-2574.2008.00001.x pmid: 19590620
9	H Seeliger, MK Christians S, A Angele, ME Kleespies, I Eichhorn, S Ischenko, V Boeck, KW Heinemann, CJ Jauch, Bruns. Risk factors for surgical complications in distal pancreatectomy. Am J Surg 2010; 200(3): 311–317 https://doi.org/10.1016/j.amjsurg.2009.10.022 pmid: 20381788
10	M Kawai, M Tani, K Okada, S Hirono, M Miyazawa, A Shimizu, Y Kitahata, H Yamaue. Stump closure of a thick pancreas using stapler closure increases pancreatic fistula after distal pancreatectomy. Am J Surg 2013; 206(3): 352–359 https://doi.org/10.1016/j.amjsurg.2012.11.023 pmid: 23806829
11	SJ Kowalsky, MS Zenati, M Dhir, EG Schaefer, A Dopsovic, KK Lee, ME Hogg, HJ Zeh, CM Vollmer, AH Zureikat. Postoperative narcotic use is associated with development of clinically relevant pancreatic fistulas after distal pancreatectomy. Surgery 2018; 163(4): 747–752 https://doi.org/10.1016/j.surg.2017.10.042 pmid: 29269087
12	T Arai, A Kobayashi, T Yokoyama, A Ohya, Y Fujinaga, A Shimizu, H Motoyama, N Furusawa, H Sakai, T Uehara, M Kadoya, S Miyagawa. Signal intensity of the pancreas on magnetic resonance imaging: prediction of postoperative pancreatic fistula after a distal pancreatectomy using a triple-row stapler. Pancreatology 2015; 15(4): 380–386 https://doi.org/10.1016/j.pan.2015.05.479 pmid: 26118649
13	YR Chang, JS Kang, JY Jang, WH Jung, MJ Kang, KB Lee, SW Kim. Prediction of pancreatic fistula after distal pancreatectomy based on cross-sectional images. World J Surg 2017; 41(6): 1610–1617 https://doi.org/10.1007/s00268-017-3872-3 pmid: 28091744
14	Y Fukuda, D Yamada, H Eguchi, Y Iwagami, T Noda, T Asaoka, H Wada, K Kawamoto, K Gotoh, M Mori, Y Doki. A novel preoperative predictor of pancreatic fistula using computed tomography after distal pancreatectomy with staple closure. Surg Today 2017; 47(10): 1180–1187 https://doi.org/10.1007/s00595-017-1495-9 pmid: 28265770
15	M Silvestri, A Coignac, J Delicque, A Herrero, F Borie, B Guiu, JM Fabre, R Souche. Level of pancreatic division and postoperative pancreatic fistula after distal pancreatectomy: a retrospective case-control study of 157 patients with non-pancreatic ductal adenocarcinoma lesions. Int J Surg 2019; 65: 128–133 https://doi.org/10.1016/j.ijsu.2019.03.020 pmid: 30954532
16	AN Martin, S Narayanan, FE Turrentine, TW Bauer, RB Adams, VM Zaydfudim. Pancreatic duct size and gland texture are associated with pancreatic fistula after pancreaticoduodenectomy but not after distal pancreatectomy. PLoS One 2018; 13(9): e0203841 https://doi.org/10.1371/journal.pone.0203841 pmid: 30212577
17	TG Flohr, S Schaller, K Stierstorfer, H Bruder, BM Ohnesorge, UJ Schoepf. Multi-detector row CT systems and image-reconstruction techniques. Radiology 2005; 235(3): 756–773 https://doi.org/10.1148/radiol.2353040037 pmid: 15833981
18	W Yang, Z Fan, Z Deng, J Pang, X Bi, BA Fraass, H Sandler, D Li, R Tuli. Novel 4D-MRI of tumor infiltrating vasculature: characterizing tumor and vessel volume motion for selective boost volume definition in pancreatic radiotherapy. Radiat Oncol 2018; 13(1): 191–198 https://doi.org/10.1186/s13014-018-1139-2 pmid: 30285889
19	RE Jimenez, WG Hawkins. Emerging strategies to prevent the development of pancreatic fistula after distal pancreatectomy. Surgery 2012; 152(3 Suppl 1): S64–S70 https://doi.org/10.1016/j.surg.2012.05.024 pmid: 22766362
20	MM Bilimoria, JN Cormier, Y Mun, JE Lee, DB Evans, PW Pisters. Pancreatic leak after left pancreatectomy is reduced following main pancreatic duct ligation. Br J Surg 2003; 90(2): 190–196 https://doi.org/10.1002/bjs.4032 pmid: 12555295
21	CR Ferrone, AL Warshaw, DW Rattner, D Berger, H Zheng, B Rawal, R Rodriguez, SP Thayer, C Fernandez-del Castillo. Pancreatic fistula rates after 462 distal pancreatectomies: staplers do not decrease fistula rates. J Gastrointest Surg 2008; 12(10): 1691–1697, discussion 1697–1698 https://doi.org/10.1007/s11605-008-0636-2 pmid: 18704597
22	I Karabicak, S Satoi, H Yanagimoto, T Yamamoto, S, Yamaki H Kosaka, S Hirooka, M Kotsuka, T Michiura, K Inoue, Y Matsui, M Kon. Comparison of surgical outcomes of three different stump closure techniques during distal pancreatectomy. Pancreatology 2017; 17(3): 497–503 https://doi.org/10.1016/j.pan.2017.04.005 pmid: 28411019
23	A Sa Cunha, N Carrere, B Meunier, JM Fabre, A Sauvanet, P Pessaux, P Ortega-Deballon, A Fingerhut, F Lacaine; French Fédération de Recherche EN Chirurgie (FRENCH). Stump closure reinforcement with absorbable fibrin collagen sealant sponge (TachoSil) does not prevent pancreatic fistula after distal pancreatectomy: the FIABLE multicenter controlled randomized study. Am J Surg 2015; 210(4): 739–748 https://doi.org/10.1016/j.amjsurg.2015.04.015 pmid: 26160763
24	DM Walters, JB Stokes, RB Adams, TW Bauer. Use of a falciform ligament pedicle flap to decrease pancreatic fistula after distal pancreatectomy. Pancreas 2011; 40(4): 595–599 https://doi.org/10.1097/MPA.0b013e3182153a4e pmid: 21499214
25	M Hassenpflug, W Hartwig, O Strobel, U Hinz, S Hackert T, MW Fritz, J Büchler, Werner. Decrease in clinically relevant pancreatic fistula by coverage of the pancreatic remnant after distal pancreatectomy. Surgery 2012; 152(3 Suppl 1): S164–S171 https://doi.org/10.1016/j.surg.2012.05.026 pmid: 22819173
26	TI Carter, ZV Fong, T Hyslop, H Lavu, WP Tan, J Hardacre, PK Sauter, EP Kennedy, CJ Yeo, EL Rosato. A dual-institution randomized controlled trial of remnant closure after distal pancreatectomy: does the addition of a falciform patch and fibrin glue improve outcomes? J Gastrointest Surg 2013; 17(1): 102–109 https://doi.org/10.1007/s11605-012-1963-x pmid: 22798186
27	M Hassenpflug, U Hinz, O Strobel, J Volpert, P Knebel, MK Diener, C Doerr-Harim, J Werner, T Hackert, MW Büchler. Teres ligament patch reduces relevant morbidity after distal pancreatectomy (the DISCOVER Randomized Controlled Trial). Ann Surg 2016; 264(5): 723–730 https://doi.org/10.1097/SLA.0000000000001913 pmid: 27455155
28	S Chen, G Chen, Y Zhao. Comment on ‘Teres ligament patch reduces relevant morbidity after distal pancreatectomy (the DISCOVER Randomized Controlled Trial)’. Ann Surg 2018; 267(5): e93–e94 https://doi.org/10.1097/SLA.0000000000002200 pmid: 28272100
29	A Oláh, A Issekutz, T Belágyi, N Hajdú, L Romics Jr. Randomized clinical trial of techniques for closure of the pancreatic remnant following distal pancreatectomy. Br J Surg 2009; 96(6): 602–607 https://doi.org/10.1002/bjs.6620 pmid: 19434697
30	T Fujii, S Yamada, K Murotani, H Sugimoto, M Hattori, M Kanda, H Takami, G Nakayama, S Nomoto, M Fujiwara, A Nakao, Y Kodera. Modified Blumgart suturing technique for remnant closure after distal pancreatectomy: a propensity score-matched analysis. J Gastrointest Surg 2016; 20(2): 374–384 https://doi.org/10.1007/s11605-015-2980-3 pmid: 26497190
31	M Wang, F Zhu, F Peng, R Tian, C Shi, M Xu, X Li, X Wang, M Shen, R Qin. Greater omentum binding: a simple technique to cover the pancreatic remnant after distal pancreatectomy. J Am Coll Surg 2014; 219(2): e19–e23 https://doi.org/10.1016/j.jamcollsurg.2014.01.066 pmid: 25038967
32	M Montorsi, A Zerbi, C Bassi, L Capussotti, R Coppola, M Sacchi; Italian Tachosil Study Group. Efficacy of an absorbable fibrin sealant patch (TachoSil) after distal pancreatectomy: a multicenter, randomized, controlled trial. Ann Surg 2012; 256(5): 853–859, discussion 859–860 https://doi.org/10.1097/SLA.0b013e318272dec0 pmid: 23095631
33	JS Park, DH Lee, JY Jang, Y Han, DS Yoon, JK Kim, HS Han, Y Yoon, D Hwang, CM Kang, HK Hwang, WJ Lee, J Heo, YR Chang, MJ Kang, YC Shin, J Chang, H Kim, W Jung, SW Kim. Use of TachoSil®patches to prevent pancreatic leaks after distal pancreatectomy: a prospective, multicenter, randomized controlled study. J Hepatobiliary Pancreat Sci 2016; 23(2): 110–117 https://doi.org/10.1002/jhbp.310 pmid: 26681272
34	CR Shubert, CR Ferrone, C Fernandez-Del Castillo, ML Kendrick, MB Farnell, RL Smoot, MJ Truty, FG Que. A multicenter randomized controlled trial comparing pancreatic leaks after TissueLink versus SEAMGUARD after distal pancreatectomy (PLATS) NCT01051856. J Surg Res 2016; 206(1): 32–40 https://doi.org/10.1016/j.jss.2016.06.034 pmid: 27916372
35	M Kawai, S Hirono, KI Okada, S Satoi, H Yanagimoto, M Kon, Y Murakami, N Kondo, M Sho, T Akahori, H Toyama, T Fukumoto, T Fujii, I Matsumoto, H Eguchi, H Ikoma, Y Takeda, J Fujimoto, H Yamaue. Reinforced staplers for distal pancreatectomy. Langenbecks Arch Surg 2017; 402(8): 1197–1204 https://doi.org/10.1007/s00423-017-1634-1 pmid: 29103084
36	I Matsumoto, Y Takeyama, K Kamei, S Satoi, Y Nakata, H Ishikawa, T Murase, M Matsumoto, T Nakai. Transpancreatic mattress suture with Vicryl mesh around the stump during distal pancreatectomy: a novel technique for preventing postoperative pancreatic fistula. J Am Coll Surg 2016; 223(2): e1–e5 https://doi.org/10.1016/j.jamcollsurg.2016.03.027 pmid: 27118710
37	JY Jang, YC Shin, Y Han, JS Park, HS Han, HK Hwang, DS Yoon, JK Kim, YS Yoon, DW Hwang, CM Kang, WJ Lee, MJ Heo JS, YR Kang, J Chang, W Chang, SW Jung, Kim. Effect of polyglycolic acid mesh for prevention of pancreatic fistula following distal pancreatectomy: a randomized clinical trial. JAMA Surg 2017; 152(2): 150–155 https://doi.org/10.1001/jamasurg.2016.3644 pmid: 27784046
38	LJ Harris, H Abdollahi, T Newhook, PK Sauter, AG Crawford, KA Chojnacki, EL Rosato, EP Kennedy, CJ Yeo, AC Berger. Optimal technical management of stump closure following distal pancreatectomy: a retrospective review of 215 cases. J Gastrointest Surg 2010; 14(6): 998–1005 https://doi.org/10.1007/s11605-010-1185-z pmid: 20306151
39	MK Diener, CM Seiler, I Rossion, J Kleeff, M Glanemann, G Butturini, A Tomazic, CJ Bruns, OR Busch, S Farkas, O Belyaev, JP Neoptolemos, C Halloran, T Keck, M Niedergethmann, K Gellert, H Witzigmann, O Kollmar, P Langer, U Steger, J Neudecker, F Berrevoet, S Ganzera, MM Heiss, SP Luntz, T Bruckner, M Kieser, MW Büchler. Efficacy of stapler versus hand-sewn closure after distal pancreatectomy (DISPACT): a randomised, controlled multicentre trial. Lancet 2011; 377(9776): 1514–1522 https://doi.org/10.1016/S0140-6736(11)60237-7 pmid: 21529927
40	P Probst, FJ Hüttner, U Klaiber, P Knebel, A Ulrich, MW Büchler, MK Diener. Stapler versus scalpel resection followed by hand-sewn closure of the pancreatic remnant for distal pancreatectomy. Cochrane Database Syst Rev 2015; 6(11): CD008688 https://doi.org/10.1002/14651858.CD008688.pub2 pmid: 26544925
41	K Okano, K Kakinoki, S Yachida, K Izuishi, H Wakabayashi, Y Suzuki. A simple and safe pancreas transection using a stapling device for a distal pancreatectomy. J Hepatobiliary Pancreat Surg 2008; 15(4): 353–358 https://doi.org/10.1007/s00534-008-1328-8 pmid: 18670834
42	M Nakamura, J Ueda, H Kohno, MYF Aly, S Takahata, S Shimizu , M Tanaka. Prolonged peri-firing compression with a linear stapler prevents pancreatic fistula in laparoscopic distal pancreatectomy. Surg Endosc 2011; 25(3): 867–871 https://doi.org/10.1007/s00464-010-1285-6 pmid: 20730447
43	T Hirashita, M Ohta, K Yada, K Tada, K Saga, H Takayama, Y Endo, H Uchida, Y Iwashita, M Inomata. Effect of pre-firing compression on the prevention of pancreatic fistula in distal pancreatectomy. Am J Surg. 2018; 216(3):506–510
44	NA Hamilton, MR Porembka, FM Johnston, F Gao, SM Strasberg, DC Linehan, WG Hawkins. Mesh reinforcement of pancreatic transection decreases incidence of pancreatic occlusion failure for left pancreatectomy: a single-blinded, randomized controlled trial. Ann Surg 2012; 255(6): 1037–1042 https://doi.org/10.1097/SLA.0b013e31825659ef pmid: 22534422
45	N Kondo, K Uemura, N Nakagawa, K Okada, S Kuroda, T Sudo, N Hadano, H Matstukawa, D Satoh, M Sasaki, S Abe T, A Fukuda, A Oshita, Y Nakashima, H Hashimoto, Y Ohdan, Murakami. A multicenter, randomized, controlled trial comparing reinforced staplers with bare staplers during distal pancreatectomy (HiSCO-07 Trial). Ann Surg Oncol 2019; 26(5): 1519–1527 https://doi.org/10.1245/s10434-019-07222-0 pmid: 30783854
46	H Kim, JY Jang, D Son, S Lee, Y Han, YC Shin, JR Kim, W Kwon, SW Kim. Optimal stapler cartridge selection according to the thickness of the pancreas in distal pancreatectomy. Medicine (Baltimore) 2016; 95(35): e4441 https://doi.org/10.1097/MD.0000000000004441 pmid: 27583852
47	S Dokmak, FS Ftériche, RL Meniconi, B Aussilhou, I Duquesne, G Perrone, C Romdhani, J Belghiti, P Lévy, O Soubrane, A Sauvanet. Pancreatic fistula following laparoscopic distal pancreatectomy is probably unrelated to the stapler size but to the drainage modality and significantly reduced with a small suction drain. Langenbecks Arch Surg 2019; 404(2): 203–212 https://doi.org/10.1007/s00423-019-01756-3 pmid: 30739172
48	T Sudo, Y Murakami, K Uemura, Y Hayashidani, Y Hashimoto, A Nakashima, H Ohge, T Sueda. Distal pancreatectomy with duct-to-mucosa pancreaticogastrostomy: a novel technique for preventing postoperative pancreatic fistula. Am J Surg 2011; 202(1): 77–81 https://doi.org/10.1016/j.amjsurg.2010.04.023 pmid: 21600558
49	H Yanagimoto, S Satoi, H Toyokawa, T Yamamoto, S Hirooka, J Yamao, S Yamaki, H Ryota, Y Matsui, AH Kwon. Pancreaticogastrostomy following distal pancreatectomy prevents pancreatic fistula-related complications. J Hepatobiliary Pancreat Sci 2014; 21(7): 473–478 https://doi.org/10.1002/jhbp.59 pmid: 24339364
50	F Klein, M Glanemann, W Faber, S Gül, P Neuhaus, M Bahra. Pancreatoenteral anastomosis or direct closure of the pancreatic remnant after a distal pancreatectomy: a single-centre experience. HPB (Oxford) 2012; 14(12): 798–804 https://doi.org/10.1111/j.1477-2574.2012.00538.x pmid: 23134180
51	M Kawai, S Hirono, K Okada, M Sho, Y Nakajima, H Eguchi, H Nagano, H Ikoma, R Morimura, Y Takeda, S Nakahira, K Suzumura, J Fujimoto, H Yamaue. Randomized controlled trial of pancreaticojejunostomy versus stapler closure of the pancreatic stump during distal pancreatectomy to reduce pancreatic fistula. Ann Surg 2016; 264(1): 180–187 https://doi.org/10.1097/SLA.0000000000001395 pmid: 26473652
52	K Uemura, S Satoi, F Motoi, M Kwon, M Unno, Y Murakami. Randomized clinical trial of duct-to-mucosa pancreaticogastrostomy versus handsewn closure after distal pancreatectomy. Br J Surg 2017; 104(5): 536–543 https://doi.org/10.1002/bjs.10458 pmid: 28112814
53	X Chen. Chen’s continuous transpancreatic transverse U-sutures technique for end-to-end invaginated pancreaticojejunostomy. J Abdom Surg (Fu Bu Wai Ke) 2019; 32(2): 77–79 (in Chinese)
54	W Hartwig, M Duckheim, O Strobel, D Dovzhanskiy, F Bergmann, T Hackert, Büchler MW, Werner J. LigaSure for pancreatic sealing during distal pancreatectomy. World J Surg 2010; 34(5): 1066–1070 https://doi.org/10.1007/s00268-010-0458-8 pmid: 20151128
55	JW Rostas, WO Richards, LW Thompson. Improved rate of pancreatic fistula after distal pancreatectomy: parenchymal division with the use of saline-coupled radiofrequency ablation. HPB (Oxford) 2012; 14(8): 560–564 https://doi.org/10.1111/j.1477-2574.2012.00499.x pmid: 22762405
56	JA Blansfield, MM Rapp, RJ Chokshi, NL Woll, MA Hunsinger, DG Sheldon, MM Shabahang. Novel method of stump closure for distal pancreatectomy with a 75% reduction in pancreatic fistula rate. J Gastrointest Surg 2012; 16(3): 524–528 https://doi.org/10.1007/s11605-011-1794-1 pmid: 22187411
57	D Dorcaratto, F Burdío, D Fondevila, A Andaluz, R Quesada, I Poves, M Caceres, X Mayol, E Berjano, L Grande. Radiofrequency is a secure and effective method for pancreatic transection in laparoscopic distal pancreatectomy: results of a randomized, controlled trial in an experimental model. Surg Endosc 2013; 27(10): 3710–3719 https://doi.org/10.1007/s00464-013-2952-1 pmid: 23584822
58	SW Behrman, BL Zarzaur, A Parmar, TS Riall, BL Hall, HA Pitt. Routine drainage of the operative bed following elective distal pancreatectomy does not reduce the occurrence of complications. J Gastrointest Surg 2015; 19(1): 72–79, discussion 79 https://doi.org/10.1007/s11605-014-2608-z pmid: 25115324
59	G 2nd Van Buren, M Bloomston, CR Schmidt, SW Behrman, NJ Zyromski, CG Ball, KA Morgan, SJ Hughes, PJ Karanicolas, JD Allendorf, CM Jr Vollmer, Q Ly, KM Brown, V Velanovich, JM Winter, AL McElhany, P 2nd Muscarella, CM Schmidt, MG House, E Dixon, ME Dillhoff, JG Trevino, NSG Hallet J, KE Coburn, AR Nakeeb A, EP Behrns, SRZ Sasson, TS Ceppa, EJ Abdel-Misih, EC Riall, DB Silberfein, C Ellison, HS Adams, S Hsu, N Tran Caol , O Mohammed, NN Villafañe-Ferrio, C Barakat, JE Massarweh, A Chai, E Mendez-Reyes, Q Fang, WE Jo, Mo, Fisher. A prospective randomized multicenter trial of distal pancreatectomy with and without routine intraperitoneal drainage. Ann Surg 2017; 266(3): 421–431 https://doi.org/10.1097/SLA.0000000000002375 pmid: 28692468
60	TF Seykora, JB Liu, L Maggino, HA Pitt, CM Jr Vollmer. Drain management following distal pancreatectomy: characterization of contemporary practice and impact of early removal. Ann Surg 20192019 Jan 30. [Epub ahead of print] https://doi.org/10.1097/SLA.0000000000003205 pmid: 30943185
61	B Rieder, D Krampulz, J Adolf, A Pfeiffer. Endoscopic pancreatic sphincterotomy and stenting for preoperative prophylaxis of pancreatic fistula after distal pancreatectomy. Gastrointest Endosc 2010; 72(3): 536–542 https://doi.org/10.1016/j.gie.2010.04.011 pmid: 20598301
62	Y Hashimoto, LW Traverso. After distal pancreatectomy pancreatic leakage from the stump of the pancreas may be due to drain failure or pancreatic ductal back pressure. J Gastrointest Surg 2012; 16(5): 993–1003 https://doi.org/10.1007/s11605-012-1849-y pmid: 22392088
63	F Frozanpor, L Lundell, R Segersvärd, U Arnelo. The effect of prophylactic transpapillary pancreatic stent insertion on clinically significant leak rate following distal pancreatectomy: results of a prospective controlled clinical trial. Ann Surg 2012; 255(6): 1032–1036 https://doi.org/10.1097/SLA.0b013e318251610f pmid: 22584629
64	T Hackert, U Klaiber, U Hinz, T Kehayova, P Probst, P Knebel, MK Diener, L Schneider, O Strobel, CW Michalski, A Ulrich, P Sauer, MW Büchler. Sphincter of Oddi botulinum toxin injection to prevent pancreatic fistula after distal pancreatectomy. Surgery 2017; 161(5): 1444–1450 https://doi.org/10.1016/j.surg.2016.09.005 pmid: 27865590
65	KS Gurusamy, R Koti, G Fusai, BR Davidson. Somatostatin analogues for pancreatic surgery. Cochrane Database Syst Rev 2013; (4): CD008370 https://doi.org/10.1002/14651858.CD008370.pub3 pmid: 23633353
66	JW Kunstman, DA Goldman, M Gönen, VP Balachandran, MI D’Angelica, TP Kingham, WR Jarnagin, PJ Allen. Outcomes after pancreatectomy with routine pasireotide use. J Am Coll Surg 2019; 228(2): 161–170.e2 " target="_blank">https://doi.org/10.1016/j.jamcollsurg.2018.10.018
67	PJ Allen, M Gönen, MF Brennan, AA Bucknor, LM Robinson, MM Pappas, KE Carlucci, MI D’Angelica, RP DeMatteo, TP Kingham, Y Fong, WR Jarnagin. Pasireotide for postoperative pancreatic fistula. N Engl J Med 2014; 370(21): 2014–2022 https://doi.org/10.1056/NEJMoa1313688 pmid: 24849084
68	H Takahashi, H Ogawa, H Ohigashi, K Gotoh, T Yamada, M Ohue, I, Miyashiro S Noura, M Kishi K, T Motoori, S Shingai, K Nakamura, M Nishiyama, O Yano, Ishikawa. Preoperative chemoradiation reduces the risk of pancreatic fistula after distal pancreatectomy for pancreatic adenocarcinoma. Surgery 2011; 150(3): 547–556 https://doi.org/10.1016/j.surg.2011.03.001 pmid: 21621236
69	NM Czosnyka, AJ Borgert, TJ Smith. Pancreatic adenocarcinoma: effects of neoadjuvant therapy on post-pancreatectomy outcomes — an American College of Surgeons National Surgical Quality Improvement Program targeted variable review. HPB (Oxford) 2017; 19(10): 927–932 https://doi.org/10.1016/j.hpb.2017.07.001 pmid: 28747265
70	M Loos, M Strobel O, M Legominski, U Dietrich, T Hinz, A Brenner, MA Heininger, MW Weigand, T Büchler, Hackert. Postoperative pancreatic fistula: microbial growth determines outcome. Surgery 2018; 164(6): 1185–1190 https://doi.org/10.1016/j.surg.2018.07.024 pmid: 30217397
71	F Yang, C Jin, S Hao, D Fu. Drain contamination after distal pancreatectomy: incidence, risk factors, and association with postoperative pancreatic fistula. J Gastrointest Surg 2019 Feb 27. [Epub ahead of print] https://doi.org/10.1007/s11605-019-04155-7doi:10.1007/s11605-019-04155-7 pmid: 30815778
72	T de Rooij, J van Hilst, H van Santvoort, D Boerma, P van den Boezem, F Daams, R van Dam, C Dejong, E van Duyn, M Dijkgraaf, C van Eijck, S Festen, M Gerhards, B Groot Koerkamp, I de Hingh, G Kazemier, J Klaase, R de Kleine, C van Laarhoven, M Luyer, G Patijn, P Steenvoorde, M Suker, M Abu Hilal, O Busch, M Besselink; Dutch Pancreatic Cancer Group. Minimally invasive versus open distal pancreatectomy (LEOPARD): a multicenter patient-blinded randomized controlled trial. Ann Surg 2019; 269(1): 2–9 https://doi.org/10.1097/SLA.0000000000002979 pmid: 30080726
73	T Hirashita, M Ohta, K Yada, K Tada, K Saga, H Takayama, Y Endo, H Uchida, Y Iwashita, M Inomata. Effect of pre-firing compression on the prevention of pancreatic fistula in distal pancreatectomy. Am J Surg 2018; 216(3): 506–510 https://doi.org/10.1016/j.amjsurg.2018.03.023 pmid: 29606277
74	K Idrees, JR Edler, DC Linehan, SM Strasberg, D Jacques, NA Hamilton, RC Fields, D Lambert, S Kymes, WG Hawkins. Cost benefit analysis of mesh reinforcement of stapled left pancreatectomy. HPB (Oxford) 2013; 15(11): 893–898 https://doi.org/10.1111/hpb.12055 pmid: 23458681
75	T Fujii, S Yamada, K Murotani, K Okamura Y, M Ishigure, S Kanda, S Takeda, A Morita, Y Nakao, Kodera. Oral Food intake versus fasting on postoperative pancreatic fistula after distal pancreatectomy: a multi-institutional randomized controlled trial. Medicine (Baltimore) 2015; 94(52): e2398 https://doi.org/10.1097/MD.0000000000002398 pmid: 26717392
76	V Pannegeon, P Pessaux, A Sauvanet, MP Vullierme, R Kianmanesh, J Belghiti. Pancreatic fistula after 340 proximal and distal pancreatectomy. Pancreatology 2017; 17(4 Supplement): S15–S16 https://doi.org/10.1016/j.pan.2017.07.053
77	D Ban, K Shimada, M Konishi, A Saiura, M Hashimoto, K Uesaka. Stapler and nonstapler closure of the pancreatic remnant after distal pancreatectomy: multicenter retrospective analysis of 388 patients. World J Surg 2012; 36(8): 1866–1873 https://doi.org/10.1007/s00268-012-1595-z pmid: 22526040

[1]	Eric C. H. Lai,Chung Ngai Tang. Robotic distal pancreatectomy versus conventional laparoscopic distal pancreatectomy: a comparative study for short-term outcomes[J]. Front. Med., 2015, 9(3): 356-360.
[2]	Xiangsong Wu, Maolan Li, Wenguang Wu, Jiasheng Mu, Lin Zhang, Qichen Ding, Qian Ding, Hao Weng, Runfa Bao, Yijun Shu, Ping Dong, Jun Gu, Jianhua Lu, Yingbin Liu. The role of prophylactic transpapillary pancreatic stenting in distal pancreatectomy: a meta-analysis[J]. Front Med, 2013, 7(4): 499-505.
[3]	Taiping Zhang, Xiao Du, Yupei Zhao. Laparoscopic surgery for pancreatic lesions: current status and future[J]. Front Med, 2011, 5(3): 277-282.

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