Fabrication and <italic>in vivo</italic> evaluation of Ti6Al4V implants with controlled porous structure and complex shape

doi:10.1007/s11465-012-0302-y

Front Mech Eng

2012, Vol. 7

Issue (1) : 66-71 https://doi.org/10.1007/s11465-012-0302-y

RESEARCH ARTICLE

Fabrication and in vivo evaluation of Ti6Al4V implants with controlled porous structure and complex shape

Xiang LI(

), Yun LUO, Chengtao WANG, Wenguang ZHANG, Yuanchao LI

School of Mechanical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China

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Abstract

Electron beam melting process was used to fabricate porous Ti6Al4V implants. The porous structure and surface topography of the implants were characterized by scanning electron microscopy (SEM) and digital microscopy (DM). The results showed that the pore size was around 600 and the porosity approximated to 57%. There was about±50 μm of undulation on implants surfaces. Standard implants and a custom implant coupled with porous sections were designed and fabricated to validate the versatility of the electron beam melting (EBM) technique. After coated with bone-like apatite, samples with fully porous structures were implanted into cranial defects in rabbits to investigate the in vivo performance. The animals were sacrificed at 8 and 12 weeks after implantation. Bone ingrowth into porous structure was examined by histological analysis. The histological sections indicated that a large amount of new bone formation was observed in porous structure. The newly formed bone grew from the calvarial margins toward the center of the bone defect and was in close contact with implant surfaces. The results of the study showed that the EBM produced Ti6Al4V implants with well-controlled porous structure, rough surface topography and bone-like apatite layer are beneficial for bone ingrowth and apposition.

Keywords electron beam melting process implant porous structure bone ingrowth

Corresponding Author(s): LI Xiang,Email:xiangliwj@sjtu.edu.cn

Issue Date: 05 March 2012

Cite this article:

Xiang LI,Yun LUO,Chengtao WANG, et al. Fabrication and in vivo evaluation of Ti6Al4V implants with controlled porous structure and complex shape[J]. Front Mech Eng, 2012, 7(1): 66-71.

URL:

https://academic.hep.com.cn/fme/EN/10.1007/s11465-012-0302-y
https://academic.hep.com.cn/fme/EN/Y2012/V7/I1/66

Fig.1 Porous samples were implanted into rabbit cranial defects

Fig.2 Resulting Ti6Al4V implants with fully porous structure

Fig.3 SEM image of the Ti6Al4V implants with fully porous structure

Fig.4 Surface topography of the resulting implants

Fig.5 The acetabular cup with surface porous structure

Fig.6 (a) CAD model of local porous structure; (b) CAD model of local porous structure on joint prosthesis; (c) the fabricated Ti6Al4V local porous structure

Fig.7 Produced cranial implant with porous structure and anatomic shape

Fig.8 Digital photographs of stained (methylene blue/basic fuchsine) histological sections of porous Ti6Al4V implants after implantation in rabbit cranium for 8 weeks. Bone is stained red and Ti6Al4V black. (a) 1.6 ×; (b) 10 ×

Fig.9 Digital photographs of stained (methylene blue/basic fuchsine) histological sections of porous Ti6Al4V implants after implantation in rabbit cranium for 12 weeks. Bone is stained red and Ti6Al4V black. (a) 1.6 ×; (b) 10 ×

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